Key takeaways
Diphenhydramine (Benadryl) and hydroxyzine (Vistaril) are both antihistamines, but they have different uses and availability. Diphenhydramine is available over-the-counter and is commonly used to treat allergies, itching, and common cold symptoms. In contrast, hydroxyzine is a prescription-only medication used to relieve itching from allergies and sometimes for anxiety. While both medications can cause drowsiness, diphenhydramine is often used as a sleep aid, whereas hydroxyzine's drowsiness effect usually lessens over time. Hydroxyzine can also affect heart rhythm and isn't recommended during pregnancy, while diphenhydramine is considered safe for short-term use during pregnancy. Additionally, hydroxyzine can be used in children younger than 6 years old, whereas diphenhydramine should not be used for trouble sleeping in children under 12 years old.
