Key takeaways
Dextromethorphan/bupropion (Auvelity) and bupropion (Wellbutrin XL, Wellbutrin SR, Forfivo XL) are both medications used to treat depression. But they have some important differences. Auvelity is a combination of dextromethorphan, which is though to boost glutamate and monoamine levels, and bupropion, which helps increase norepinephrine and dopamine levels. In contrast, bupropion is an atypical antidepressant that boosts just norepinephrine and dopamine and is available in various formulations, including immediate-release, sustained-release, and extended-release tablets. Auvelity is only available as a brand-name medication, while bupropion is available as a lower-cost generic. Auvelity is typically taken twice daily, while bupropion dosing varies depending on the formulation but is usually taken 1-3 times daily. Both medications can cause dizziness and increase the risk of seizures, especially if you have a history of seizures or eating disorders. Auvelity can work faster, often improving symptoms within a week, while bupropion may take several weeks to show effects. It's best to avoid drinking alcohol with either medication.
