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Augmentin vs. Cipro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Augmentin (amoxicillin/clavulanate) and Cipro (ciprofloxacin) are both antibiotics used to treat bacterial infections, but they belong to different drug classes and have distinct uses and side effects. Augmentin is a combination of a penicillin antibiotic and a beta-lactamase inhibitor, making it effective against bacteria that can resist amoxicillin alone. It is commonly used for ear, sinus, respiratory, skin, and urinary tract infections. Cipro, on the other hand, is a fluoroquinolone antibiotic that works by blocking enzymes bacteria need to grow and repair their DNA. It is used for more serious infections like bone, joint, and lower respiratory tract infections, and is also an option for those allergic to penicillin. While both medications can cause diarrhea and nausea, Cipro has more severe potential side effects, such as tendon rupture and nerve damage, and is generally reserved for cases where other antibiotics are not suitable. Additionally, Cipro can interact with many medications and requires caution with sun exposure, whereas Augmentin is safer for use during pregnancy and breastfeeding.

Augmentin

(amoxicillin / clavulanate)

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Ciprofloxacin

(Cipro)

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Summary for Augmentin

Prescription only

Augmentin (amoxicillin / clavulanate) is an antibiotic medication. It contains a penicillin and a beta-lactamase inhibitor. This antibiotic treats many types of bacterial infections, like urinary tract infection (UTI), sinus infection, and ear infection, among others. It fights infections by preventing bacteria from protecting themselves from harm. This medication comes as tablets, chewable tablets, and a suspension that are taken by mouth typically two to three times daily. It's approved for use in adults and children. Common side effects include diarrhea, nausea, and rash.

Indications for Augmentin

Pros and Cons for Augmentin

Pros

  • Treats many types of bacterial infections in children and adults
  • Available as a tablet, chewable tablet, and oral suspension
  • Available as a lower-cost generic
  • Safe to use while pregnant and while breastfeeding

Cons

  • Typically need to take 2 or 3 times daily
  • Might not be able to take this antibiotic if you've had a severe penicillin allergy
  • Can cause stomach side effects like nausea, vomiting, and diarrhea

Common Side Effects for Augmentin

Immediate-release tablets, chewable tablets, and suspension

  • Diarrhea or loose stools (9%)
  • Nausea (3%)
  • Skin rash (3%)

Extended-release tablets

  • Diarrhea (15%)
  • Vaginal yeast infection (3%)

Augmentin ES-600 (amoxicillin / clavulanate) suspension

  • Vomiting (7%)
  • Fever (6%)
  • Rash (6%)
  • Upper respiratory tract infection (e.g., common cold; 4%)
  • Diarrhea (4%)

Warnings for Augmentin

  • Severe allergic reactions and skin reactions
  • Liver problems
  • Diarrhea from Clostridioides difficile infection
  • Caution use in people with phenylketonuria (PKU) - for chewable tablets and suspension

Summary for Cipro

Prescription only

Ciprofloxacin (Cipro) is a fluoroquinolone antibiotic. It can treat many types of bacterial infections, including sinus infections and urinary tract infections (UTIs). But because ciprofloxacin (Cipro) can cause serious side effects, such as tendon rupture and nerve damage, it's usually only prescribed for more serious infections or when there aren't any safer options. Ciprofloxacin (Cipro) is taken by mouth, typically twice daily. It's available as a pill and oral solution. Some of the more common side effects of this medication include nausea and diarrhea.

Indications for Cipro

Adults only

Adults and children

Pros and Cons for Cipro

Pros

  • Can take with or without food
  • Available as tablets, oral liquid, and injection
  • Possible option for people with penicillin allergy

Cons

Common Side Effects for Cipro

  • Nausea
  • Diarrhea
  • Vomiting
  • Rash
  • Abnormal liver blood test results

Warnings for Cipro

  • Tendon inflammation and rupture
  • Effects on the brain, nerves, and mental health
  • Worsening of myasthenia gravis
  • Severe allergic and skin reactions
  • Liver damage
  • Severe damage to a major blood vessel
  • Infectious diarrhea
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Muscle, bone, or joint problems in children
  • Sun and light sensitivity
  • Kidney problems

Prices with our coupons for Augmentin vs. Cipro

Price Card Drug Icon
Amoxicillin/Potassium Clavulanate20 tablets / 875mg/125mg
$13.79$34.94
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Price Card Drug Icon
Ciprofloxacin14 tablets / 500mg
$10.88$13.08
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