Key takeaways
Hydroxyzine (Vistaril) and cetirizine (Zyrtec) are both antihistamines that treat allergy-related symptoms. Cetirizine is available over-the-counter and is less likely to cause drowsiness than hydroxyzine. Cetirizine is also considered safe to take during pregnancy, while hydroxyzine isn't recommended. Hydroxyzine is only available by prescription. It's also approved to treat short-term anxiety, while cetirizine isn't approved for this use. But hydroxyzine can cause severe drowsiness and may not be safe for older adults or thse with a heart-related condition.
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