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Aplenzin vs. Wellbutrin XL

Aplenzin, the brand name for extended-release bupropion hydrobromide, is an atypical antidepressant. It's used to treat depression and seasonal affective disorder (SAD) in adults. This medication is a tablet that's taken by mouth once per day. The dosage generally depends on how well the medication improves your mood. Side effects include headache, dry mouth, and nausea. Aplenzin (bupropion) isn't yet available as a generic.

• Major depressive disorder (MDD)
• Seasonal affective disorder (SAD)

• Headache (26%)
• Dry mouth (17%)
• Nausea (13%)
• Trouble sleeping (11%)
• Constipation (10%)
• Dizziness (7%)

• Worsening depression and suicidal thoughts and behavior
• Changes in mental health
• Not for use alone in bipolar disorder
• Seizures
• High blood pressure
• Glaucoma
• Severe allergic reaction and skin reaction

Bupropion is taken by mouth to treat depression and seasonal affective disorder (SAD). It's available as short-acting tablets that are taken two or three times a day, as well as long-acting versions that are taken once daily. Bupropion has fewer sexual side effects compared to other antidepressants, but it's not a good choice for people with a history of seizures, eating disorders, or drink alcohol regularly.

• Depression
• Seasonal affective disorder (SAD) - only bupropion HCl extended-release (Wellbutrin XL)

• Headache
• Dry mouth
• Nausea
• Trouble sleeping
• Dizziness
• Sore throat
• Constipation
• Restlessness (agitation)

• Suicidal thoughts or behavior and abnormal mood changes
• Mental health changes
• Seizures
• High blood pressure
• Extreme enthusiasm or excitement (mania)