Aplenzin vs. Wellbutrin XL for Depression: Important Differences and Potential Risks.

Aplenzin

(bupropion)

Get free coupons

Save more on select medications with GoodRx Companion.

Bupropion

Get free coupons

Save more on select medications with GoodRx Companion.

Summary for Aplenzin

Prescription only

Aplenzin, the brand name for extended-release bupropion hydrobromide, is an atypical antidepressant. It's used to treat depression and seasonal affective disorder (SAD) in adults. This medication is a tablet that's taken by mouth once per day. The dosage generally depends on how well the medication improves your mood. Side effects include headache, dry mouth, and nausea. Aplenzin (bupropion) isn't yet available as a generic.

Indications for Aplenzin

Pros and Cons for Aplenzin

Pros

First-choice option for mild-to-moderate depression
Taken by mouth once per day
Lower risk of sexual side effects and weight gain than other antidepressants

Cons

Only available as an extended-release tablet that's swallowed whole
Can cause trouble sleeping if you take it too late in the day
Can raise the risk of seizures and high blood pressure

Common Side Effects for Aplenzin

Headache (26%)
Dry mouth (17%)
Nausea (13%)
Trouble sleeping (11%)
Constipation (10%)
Dizziness (7%)

Warnings for Aplenzin

Worsening depression and suicidal thoughts and behavior
Changes in mental health
Not for use alone in bipolar disorder
Seizures
High blood pressure
Glaucoma
Severe allergic reaction and skin reaction

Summary for Wellbutrin XL

Prescription only

Bupropion is taken by mouth to treat depression and seasonal affective disorder (SAD). It's available as short-acting tablets that are taken two or three times a day, as well as long-acting versions that are taken once daily. Bupropion has fewer sexual side effects compared to other antidepressants, but it's not a good choice for people with a history of seizures, eating disorders, or drink alcohol regularly.

Indications for Wellbutrin XL

Depression
Seasonal affective disorder (SAD) - only bupropion HCl extended-release (Wellbutrin XL)

Pros and Cons for Wellbutrin XL

Pros

Works well for depression and can be used alone or in combination with other antidepressants
Causes fewer sexual side effects than some other antidepressants
Available in a lower-cost generic form
Less likely to cause weight gain compared to other antidepressants
Good option for people who haven't had success with traditional antidepressants like selective serotonin reuptake inhibitors (SSRIs)

Cons

Can take several weeks to feel the full effects
Not the best option if you have a history of seizures or eating disorders like as anorexia or bulimia
Might need to limit or avoid using alcohol during treatment
Can cause trouble sleeping if you take it later in the day

Common Side Effects for Wellbutrin XL

Headache
Dry mouth
Nausea
Trouble sleeping
Dizziness
Sore throat
Constipation
Restlessness (agitation)

Warnings for Wellbutrin XL

Suicidal thoughts or behavior and abnormal mood changes
Mental health changes
Seizures
High blood pressure
Extreme enthusiasm or excitement (mania)

Prices with our coupons for Aplenzin vs. Wellbutrin XL

Aplenzin30 tablets / 348mg

$3,740.65$4,052.98

Get free coupons

More Information

Bupropion30 tablets / 75mg

$8.42$8.42

Get free coupons

More Information

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.

Compare
Aplenzin vs. Wellbutrin XL

Aplenzin

Bupropion

Summary for Aplenzin

Indications for Aplenzin

Pros and Cons for Aplenzin

Pros

Cons

Common Side Effects for Aplenzin

Warnings for Aplenzin

Summary for Wellbutrin XL

Indications for Wellbutrin XL

Pros and Cons for Wellbutrin XL

Pros

Cons

Common Side Effects for Wellbutrin XL

Warnings for Wellbutrin XL

Prices with our coupons for Aplenzin vs. Wellbutrin XL

Compare other Depression drugs

Browse medications by letter

Good news for your inbox

Aplenzin

Bupropion

Summary for Aplenzin

Indications for Aplenzin

Pros and Cons for Aplenzin

Pros

Cons

Common Side Effects for Aplenzin

Warnings for Aplenzin

Summary for Wellbutrin XL

Indications for Wellbutrin XL

Pros and Cons for Wellbutrin XL

Pros

Cons

Common Side Effects for Wellbutrin XL

Warnings for Wellbutrin XL