Key takeaways
Fexofenadine (Allegra) and Allegra-D (fexofenadine/pseudoephedrine) are both used to treat allergy symptoms, but they have some key differences. Fexofenadine (Allegra) is a second-generation antihistamine that helps relieve symptoms like sneezing, runny nose, and itchy eyes. It is available over-the-counter in various forms, including tablets, liquid, and fast-melting tablets. Allegra-D, on the other hand, is a combination of fexofenadine and pseudoephedrine, which adds a decongestant to help clear your sinuses. This makes Allegra-D effective for both allergies and congestion. However, Allegra-D can cause more side effects like trouble sleeping and anxiety due to the pseudoephedrine. Allegra-D can also raise your blood pressure so it may not be the best option if you have hypertension (high blood pressure). Additionally, Allegra-D is found behind the pharmacy counter because the pseudoephedrine component carries a potential for abuse. Both medications should be taken on an empty stomach and not with fruit juices, but Allegra-D should be swallowed whole without cutting or crushing the tablets.
