Key takeaways
Alka-Seltzer (citric acid/aspirin/sodium bicarbonate) and Omeprazole (Prilosec) are both used to treat heartburn, but they work in different ways and have different uses. Alka-Seltzer is a combination of an antacid and a nonsteroidal anti-inflammatory drug (NSAID), which helps neutralize stomach acid and relieve pain and inflammation. It is available over-the-counter and is typically taken every 4 to 6 hours as needed. Omeprazole, on the other hand, is a proton pump inhibitor (PPI) that reduces the amount of acid your stomach produces. It is available both over-the-counter and by prescription and is usually taken once daily before breakfast. Alka-Seltzer provides quick relief but may need to be taken multiple times a day, while Omeprazole takes longer to work but offers longer-lasting relief. Alka-Seltzer contains aspirin, which can cause stomach bleeding and is not recommended for children or pregnant women. Omeprazole can interact with many medications and is not recommended for long-term use due to risks like bone fractures and low vitamin B12 levels. Both medications have generic forms available.
