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Breztri Aerosphere Coupon - Breztri Aerosphere 120 inhalations of 160mcg/9mcg/4.8mcg inhaler

Breztri

budesonide / glycopyrrolate / formoterol
Used for COPD
Used for COPD

Breztri Aerosphere is a combination inhaler that contains budesonide (an inhaled corticosteroid), glycopyrrolate (a long-acting muscarinic antagonist), and formoterol (a long-acting beta agonist). It's used for maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. Breztri is inhaled through the mouth and into the lungs twice per day every day. The most common side effects are upper respiratory tract infections and pneumonia. Breztri is brand name only and not available as a lower-cost generic.

Last reviewed on September 11, 2024
basics-icon

What is Breztri?

What is Breztri used for?

How Breztri works

Breztri is a combination inhaler containing three medications that work together so you can breathe more easily.

Are you looking for information on Bevespi Aerosphere (glycopyrrolate / formoterol) instead?
When does Breztri start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsBreztri Aerosphere
Drug ClassICS / LAMA / LABA
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$796.940
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What are the side effects of Breztri?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction: hives, swelling of your face, lips, or tongue, difficulty breathing
  • Sudden narrowing of your airways: difficulty breathing, wheezing, chest pain or tightness, cough
  • Heart problems: dizziness, fatigue, tremor, nausea, rapid heartbeat, weakness, difficulty sleeping
When do Breztri possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Cough
Throat irritation
Risk of oral thrush
Risk of respiratory infections
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Increase in blood pressure
  • Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
  • Muscle pain or cramps
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
  • Thrush—white patches in the mouth
  • Trouble passing urine
  • Wheezing or trouble breathing that is worse after use

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Breztri

thumbs-up

Pros

Lowers the risk of COPD flare-ups

Combination of three medications in a single inhaler

Can be used with a spacer to make it easier to take a dose

thumbs-down

Cons

Need to rinse your mouth after each dose

Need to inhale 2 puffs twice daily

Doesn't treat sudden worsening symptoms of COPD

pharmacist-tips

Pharmacist tips for Breztri

pharmacist
  • Take 2 puffs of Breztri in the morning and 2 puffs in the evening every day. Use Breztri as prescribed at the same times each day to make sure it works as best as possible to treat your COPD.

    • Breztri isn't meant to be used to treat sudden difficulty breathing. Always have your rescue inhaler (e.g., albuterol (Ventolin)), handy in case you have sudden trouble breathing.

      • Call your pulmonologist if your breathing or peak flow meter results worsen. Also contact your pulmonologist if you're using your rescue inhaler more often than usual. These could be signs that Breztri isn't working well to control your COPD symptoms.

        • Store Breztri at room temperature in a dry place away from heat or sunlight. Keep unused inhalers in the original foil pouch.

          • After you've removed Breztri from the original pouch, this inhaler expires after 3 months. Throw the inhaler away after 3 months or when the dose indicator display window shows "0", whichever comes first.

            • You'll need to prime your Breztri inhaler to make sure you get the full dose. To prime it for the first time, shake it well and spray into the air away from your face 4 times. Make sure to shake before each spray. If you haven't used your Breztri inhaler in a week or longer, you'll need to prime it again by spraying it 2 times into the air.

              • Shake the Breztri inhaler well before each dose to mix the medication. When you're ready, place your lips firmly around the mouthpiece, and slightly tilt your head back. Then, take a slow and deep breath while you push the top of the canister down to deliver the medication.

                • Try to hold your breath for as long as you comfortably can (up to 10 seconds) so that the medication can reach deep into your lungs. Then, repeat these steps to take your second dose of Breztri.

                  • Clean your Breztri inhaler once a week to prevent medication from building up in the mouthpiece. To do so, remove the cap and canister and set them aside. Then, rinse the mouthpiece and top of the inhaler with warm running water for 30 seconds each. Shake off any extra water and let it fully air dry before putting your inhaler back together.

                    • When the pointer in the display window of the Breztri dose counter is in the yellow zone, you should get a refill.

                      faqs

                      Frequently asked questions about Breztri

                      Is Breztri a steroid?
                      Yes. Budesonide in Breztri is an inhaled corticosteroid (or steroid). It's purpose is to lower inflammation in the lungs, which helps to keep your airways open and help you breathe better.
                      How long does it take for Breztri to work?
                      Studies show Breztri can start to improve breathing within 5 minutes of taking a dose. But it can take several weeks before you notice a difference in how well it keeps COPD flare-ups under control. Keep in mind Breztri isn't recommended to treat a COPD attack or sudden trouble breathing. Talk with your pulmonologist if you have more questions about how long it takes for Breztri to work.
                      How long does Breztri stay in your system?
                      It might take about a day for most of budesonide, about 3 days for most of glycopyrrolate, and 2 days for most of formoterol to leave your body after an inhalation of Breztri. This time frame is estimated based on the half-life of each medication in Breztri. But keep in mind that you need to take Breztri twice daily for it to work well to control COPD.
                      Why is Breztri not for asthma?
                      Breztri has specifically only been studied in people with COPD, not asthma. There's not enough information to know whether Breztri is safe or works well for people with asthma. There are several other combination inhalers approved for asthma, including Trelegy Ellipta, that might be more appropriate. Talk with your pulmonologist if you have questions about combination inhalers for asthma.
                      Is Breztri the same as Trelegy?
                      No, Breztri and Trelegy Ellipta aren't the same. They're both combination inhalers that contains an ICS, LAMA, and LABA. But Breztri (budesonide / glycopyrrolate / formoterol) is only approved for COPD, while Trelegy Ellipta (fluticasone / umeclidinium / vilanterol) is approved for COPD and asthma. In addition, Breztri is inhaled twice daily, whereas Trelegy Ellipta is inhaled once daily. Lastly, Breztriis a type of inhaler called a metered dose inhaler that delivers the medication as a mist. But Trelegy Ellipta is an Ellipta inhaler that delivers the medication as a dry powder. Talk to your pulmonologist if you have specific questions about the differences of each inhaler.
                      Can you use Breztri and albuterol together?
                      Your pulmonologist will likely prescribe you albuterol (Ventolin) as a rescue inhaler when you're taking Breztri. This is because Breztri is a long-acting medication that works over time to lessen inflammation and swelling in your lungs and open your airways. But it won't help if you have sudden trouble breathing during a COPD flare up. A rescue inhaler, such as albuterol (Ventolin), works quickly and can relieve sudden symptoms, such as coughing and wheezing. Ask your healthcare team if you have more questions about Breztri and rescue inhalers.
                      Does Breztri cause hair loss?
                      People using Breztri in clinical studies didn't report hair loss as a side effect. Contact your primary care provider if you notice signs of hair loss so they can help you figure out possible causes.
                      Does Breztri cause weight gain?
                      Weight gain wasn't reported in people taking Breztri in clinical studies. Breztri contains budesonide, which is a corticosteroid, and corticosteroids are known to cause weight gain especially when taken by mouth. But because Breztri is inhaled, it's unlikely to get absorbed into the rest of your body and cause weight gain. Talk with your primary care provider if you experience unexplained weight gain so they can help figure out a cause.
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                      warings-icon

                      What are the risks and warnings for Breztri?

                      Breztri can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                      risk-warning

                      Not for asthma, COPD flare ups, or worsening breathing

                      Don't use Breztri if you're experiencing a COPD flare-up because this medication won't provide immediate relief. Use a rescue inhaler, such as albuterol (Ventolin HFA), if you're having trouble breathing.

                      If you're using your rescue inhaler more often than usual, let your pulmonologist know because this could be a sign that your condition is getting worse. Don't use more doses Breztri than recommended because this won't improve your breathing. Rather, this can raise your risk for serious side effects, such as heart problems, tremors, and dizziness.

                      In addition, don't use Breztri with other inhalers containing a LABA, such as Serevent Diskus (salmeterol) or formoterol (Perforomist). Doing so can also worsen side effects.

                      Breztri isn't FDA-approved to treat asthma. Don't use this medication if you have asthma.

                      risk-warning

                      Fungal infection in the mouth

                      • Risk factors: Not rinsing and spitting after using Breztri | Weakened immune system from medical conditions or medications

                        Breztri contains budesonide, a steroid medication. When inhaled, it can cause a fungal infection in your mouth and throat called thrush. The risk is highest during the first 3 months after you start this medication. To lower your risk for thrush, rinse your mouth with water and spit after each inhalation of Breztri. If you develop thrush, your pulmonologist might prescribe you a medication to treat this condition and ask you to temporarily stop using Breztri. Let your pulmonologist know if you notice symptoms of thrush, such as white patches in your mouth, cotton-like feeling in your mouth, pain while eating or swallowing, or loss of taste.

                        risk-warning

                        Narrowing of your airways (bronchospasm)

                        Inhaled medications, including Breztri, can sometimes cause a muscle spasm in your lungs. This can lead to difficulty breathing, wheezing, cough, and chest discomfort. If you have a hard time breathing after inhaling Breztri, use your rescue inhaler and get medical attention right away.

                        risk-warning

                        Allergic reactions

                        Allergic reactions to Breztri are possible. These reactions can include life-threatening facial swelling, shock, and anaphylaxis (closing of the throat). Get medical attention right away if you notice hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing after you use Breztri.

                        risk-warning

                        Higher risk of infections

                        Like all corticosteroid-containing medications, Breztri can weaken your immune system and raise your risk for infections, including upper respiratory infections and pneumonia. Your risk for infections is higher if you're also taking other medications that also weaken your immune system. If you're currently being treated for a serious infection, such as tuberculosis, let your pulmonologist know. They might need to consider a different medication for your condition until you get better. Let your pulmonologist or primary care provider know right away if you have symptoms of infections, such as fever, chills, or body aches.

                        risk-warning

                        Changes in stress hormone levels

                        • Risk factors: Using Breztri for a long time | Using too much Breztri

                          Use Breztri only as directed. Don't use more than the maximum number of inhalations each day. Doing so can cause more of the steroid to be absorbed into the body and raise your risk for symptoms such as higher blood sugar or blood pressure.

                          On the other hand, if you're transitioning to Breztri from oral steroids, you might experience symptoms of low steroid hormone, such as stomach pain, loss of appetite, and nausea. When you transition to Breztri, your pulmonologist will work with you to lower your dose of oral steroids slowly over time to prevent these side effects.

                          risk-warning

                          Eye and vision problems

                          • Risk factors: Long-term use of Breztri | History of glaucoma | History of high eye pressure

                            Although rare, people using inhaled steroids or anticholinergics over a long period of time have reported having higher pressure in the eyes, glaucoma, and cataracts. Since Breztri contains budesonide (a steroid) and glycopyrrolate (an anticholinergic), talk to your optometrist before using Breztri if you have glaucoma or cataracts because they might ask you to come in more often for eye exams. Also speak with them if you notice any changes to your vision while using the medication.

                            risk-warning

                            Heart problems

                            • Risk factors: High blood pressure | Heart failure | Heart rate or rhythm problems | Using more Breztri than recommended

                              The formoterol in Breztri might cause changes in your blood pressure, heart rate, and heart rhythm. But these side effects are typically unlikely to happen if you're taking the recommended dose of Breztri. Your pulmonologist or cardiologist might ask you to regularly check your blood pressure and heart rate at home if you have high blood pressure or other heart problems. Don't use Breztri more often than recommended. If you find that you need to use Breztri more often, let your care team know so they can see if you need any changes to your treatment plan. Tell your pulmonologist if you have dizziness, fatigue, tremor, rapid heartbeat, or weakness after you use Breztri.

                              risk-warning

                              Low potassium levels in the blood

                              • Risk factors: Using Breztri too much

                                Formoterol in Breztri can cause the potassium levels in your blood to drop too low. In most cases, this happens if you use more Breztri than recommended. Drops in blood potassium levels are typically mild and your levels should go back to usual with time. Sometimes, low potassium can cause tiredness, weakness, muscle cramps, a racing heart, and a "pins and needles" feeling in your hands and feet. Tell your prescriber if you experience any of these symptoms while you're using Breztri. Also let your prescriber know if you need to use Breztri more often than instructed. Your treatment plan might need to be adjusted to better control your symptoms.

                                risk-warning

                                Trouble urinating

                                • Risk factors: Enlarged prostate | Bladder-neck obstruction (blockage)

                                  Breztri should be used cautiously by people who have prostate problems or urinary retention, because glycopyrrolate in Breztri can cause difficulty urinating. Contact your prescriber if you notice difficulty urinating while using this medication.

                                  dosage

                                  Breztri dosage forms

                                  Typical dosing for Breztri

                                  Each inhalation of Breztri contains 160 mcg of budesonide, 9 mcg of glycopyrrolate, and 4.8 mcg of formoterol.

                                  The typical dose is 2 inhalations by mouth twice per day (in the morning and in the evening).

                                  contraindications-icon

                                  Breztri contraindications

                                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Breztri will not be safe for you to take.
                                  • Treatment of sudden trouble breathing

                                  • Allergy to budesonide (inhaled corticosteroid), glycopyrrolate (an anticholinergic), or formoterol (long-acting beta agonist)

                                  alternatives

                                  What are alternatives to Breztri?

                                  There are a number of medications that your doctor can prescribe in place of Breztri. Compare a few possible alternatives below.
                                  Breztri
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                                  Breztri images

                                  white - BREZTRI AEROSPHERE 160mcg-9mcg-4.8mcg / actuation Inhalation Aerosol
                                  This medicine is White Inhaler.white - BREZTRI AEROSPHERE 160mcg-9mcg-4.8mcg / actuation Inhalation Aerosol

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                                  References

                                  Best studies we found

                                  American Lung Association. (2024). How to use a metered-dose inhaler without a valved holding chamber.

                                  American Lung Association. (2024). Measuring your peak flow rate.

                                  American Thoracic Society. (2014). Using your metered dose inhaler (MDI). American Journal of Respiratory and Critical Care Medicine.

                                  View All References (9)

                                  American Thoracic Society. (2018). Exacerbation of COPD. American Journal of Respiratory and Critical Care Medicine.

                                  AstraZeneca. (2024). Learn how to use your Breztri inhaler.

                                  AstraZeneca Pharmaceuticals LP. (2022). Breztri- budesonide, glycopyrrolate, and formoterol fumarate aerosol, metered [package insert]. DailyMed.

                                  DelGaudio, J.M. (2002). Steroid Inhaler LaryngitisDysphonia Caused by Inhaled Fluticasone Therapy. JAMA Otolaryngology-Head & Neck Surgery.

                                  Korsgaard, J., et al. (2009). Potential side effects in patients treated with inhaled corticosteroids and long-acting b2-agonists. Respiratory Medicine.

                                  MedlinePlus. (2016). Cushing’s syndrome.

                                  National Institute for Health and Care Excellence (NICE). (2018). LAMA monotherapy. NICE Guideline.

                                  National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Symptoms & causes of adrenal insufficiency & Addison’s disease.

                                  van Boven, J.F.M., et al. (2013). Inhaled corticosteroids and the occurrence of oral candidiasis: a prescription sequence symmetry analysis. Drug Safety.

                                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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