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Bonjesta

doxylamine / pyridoxine
Used for Morning Sickness
Used for Morning Sickness

Bonjesta (doxylamine / pyridoxine) treats morning sickness, or nausea and vomiting that happens during pregnancy. It's typically taken when changing your diet or staying away from nausea triggers isn't enough help. This medication contains an antihistamine called doxylamine and a dietary supplement called pyridoxine (also known as vitamin B6). The dosage is 1 tablet taken by mouth at bedtime, but it can be adjusted to 1 tablet in the morning and 1 tablet at bedtime if needed. This medication commonly causes sleepiness as a side effect.

Last reviewed on November 12, 2024
basics-icon

What is Bonjesta (doxylamine / pyridoxine)?

What is Bonjesta (doxylamine / pyridoxine) used for?

  • Morning sickness (nausea and vomiting during pregnancy) when non-medication options haven't provided enough relief

How Bonjesta (doxylamine / pyridoxine) works

Bonjesta (doxylamine / pyridoxine) is a combination medication containing two active ingredients that are thought to work together to relieve symptoms of morning sickness.

  • Doxylamine is an antihistamine. It blocks a natural chemical in the body called histamine from turning on the part of the brain that's responsible for nausea and vomiting.

  • Pyridoxine, another name for vitamin B6, is a dietary supplement. It's not clear how pyridoxine helps lessen nausea and vomiting during pregnancy.

Are you looking for information on Diclegis (doxylamine / pyridoxine) instead?
When does Bonjesta (doxylamine / pyridoxine) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsBonjesta
Drug ClassAntihistamine / Dietary supplement
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$842.43(save 76.35%)
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$199.20
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What are the side effects of Bonjesta (doxylamine / pyridoxine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Sleepiness (14%)

Other Side Effects

  • Stomach pain
  • Constipation
  • Diarrhea
  • Chest discomfort
  • Tiredness
  • Dizziness
  • Headache
  • Balance problems
  • Blurry vision
Note: Side effects were based on studies with people who took 10 mg of doxylamine and 10 mg of pyridoxine.

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Accidentally taking too much medication: extreme sleepiness, dry mouth, restlessness, feeling like your surroundings are spinning, fast heart rate, confusion
When do Bonjesta (doxylamine / pyridoxine) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Sleepiness

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Blurred or loss of vision

burning feeling while urinating

chest discomfort

decrease in the frequency of urination

decrease in urine volume

difficult or labored breathing

difficult or painful urination

disturbed color perception

double vision

fast, irregular, pounding, or racing heartbeat or pulse

fever

halos around lights

headache, severe and throbbing

hives, itching, skin rash

hoarseness

irritation

joint pain, stiffness, or swelling

night blindness

overbright appearance of lights

redness of the skin

stomach distension or pain

swelling of the eyelids, face, lips, hands, or feet

tightness in the chest

troubled breathing or swallowing

tunnel vision

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Unusual drowsiness

Incidence not known

Anxiety

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

confusion about identity, place, and time

constipation

diarrhea

dizziness or lightheadedness

feeling of constant movement of self or surroundings

general feeling of discomfort or illness

headache

increased sweating

irritability

nightmares

sensation of spinning

trouble sleeping

unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Bonjesta (doxylamine / pyridoxine)

thumbs-up

Pros

One of the few medications that's FDA approved for morning sickness during pregnancy

Combines two medications into one tablet for convenience

Dose ranges from 1 to 2 tablets per day, depending on your needs

thumbs-down

Cons

Can cause sleepiness

Not for severe nausea and vomiting during pregnancy (hyperemesis gravidarum)

Not known whether it works well or is safe for people under 18 years old

pharmacist-tips

Pharmacist tips for Bonjesta (doxylamine / pyridoxine)

pharmacist
  • Take Bonjesta (doxylamine / pyridoxine) on an empty stomach with a full glass of water. Food can make the medication take longer to work and also lessen how much of the medication gets absorbed into the body.

    • Swallow Bonjesta (doxylamine / pyridoxine) tablets whole. Don't crush, chew, or break the tablets before you swallow. Otherwise, the medication might not last as long in your system. Talk to your prescriber if you have trouble swallowing the tablets whole.

      • You can feel sleepy after you take Bonjesta (doxylamine / pyridoxine). Don't drive or do any activities that you need to concentrate for until you speak with your prescriber after you start taking this medication. It's dangerous to drive when you're sleepy, have trouble thinking clearly, or can't react quickly.

        • Avoid taking other antihistamines while you're taking Bonjesta (doxylamine / pyridoxine). It can put you at higher risk for serious side effects, like extreme sleepiness and confusion. Over-the-counter allergy, cough and cold medications, and sleep aids commonly have antihistamines in them. Ask your pharmacist if you're not sure whether any of your other medications contain an antihistamine.

          • Give your care team an up-to-date list of medications that you're taking. They can make sure your medications are safe to take together. It's not recommended to take Bonjesta (doxylamine / pyridoxine) if you're taking other medications that cause sleepiness, like muscle relaxers, sleep aids, and anxiety medications. It can cause severe sleepiness, which can lead to accidents and falls.

            • Other ways to help with morning sickness include eating dry crackers in bed in the morning so you're not moving around on an empty stomach. Then, make sure to drink enough water during the day. In addition, it can be easier on the stomach if you eat smaller portions of food (five or six smaller meals) instead of a few large meals throughout the day. You can also try ginger candies, ginger ale, and ginger tea.

              faqs

              Frequently asked questions about Bonjesta (doxylamine / pyridoxine)

              Is Bonjesta (doxylamine / pyridoxine) safe in the first trimester of pregnancy?
              Yes, Bonjesta (doxylamine / pyridoxine) is safe to take in the first trimester of pregnancy. Findings from many studies show that this combination medication doesn't raise the risk for birth defects when it's taken during this stage of pregnancy. Speak with your prescriber if you have concerns about taking Bonjesta (doxylamine / pyridoxine) while you're pregnant.
              How long can you take Bonjesta (doxylamine / pyridoxine) during pregnancy?
              There isn't a maximum amount of time that you can take Bonjesta (doxylamine / pyridoxine) for during pregnancy. Discuss with your prescriber about how long you should take the medication for. They might recommend that you continue to take Bonjesta (doxylamine / pyridoxine) as prescribed if you still need it, as long as it's helping with your morning sickness and as long as side effects from the medication aren't bothersome. While you're taking the medication, you can continue to do other things to help, such as eating smaller portions of food throughout the day and staying hydrated.
              How long does Bonjesta (doxylamine / pyridoxine) take to work?
              It typically takes a few hours for each dose of Bonjesta (doxylamine / pyridoxine) to work to lessen nausea and vomiting during pregnancy. When you take the medication at bedtime, it can start working early in the morning the next day. If you need more relief throughout the day, you can take the medication every morning and night to cover the entire day. In a clinical study, it took up to 2 weeks for people between 7 and 14 weeks of pregnancy who took 10 mg of doxylamine and 10 mg of pyridoxine to notice significant improvement in their morning sickness. Ask your prescriber if you have questions about how long it's taking for Bonjesta (doxylamine / pyridoxine) to work for you.
              How soon can I eat after taking Bonjesta (doxylamine / pyridoxine)?
              It's not clear how soon you can eat after you take Bonjesta (doxylamine / pyridoxine). It's recommended that you take the medication on an empty stomach. If you do eat food right after you take Bonjesta (doxylamine / pyridoxine), be sure that it's low fat and low calorie. Studies show that taking the medication with high-fat, high-calorie meals makes the medication take longer to work. It can also lessen how much of the medication gets absorbed into the body. In addition, it's generally recommended to eat smaller potions of food (five or six smaller meals) instead of a few large meals throughout the day so food is easier on the stomach.
              Are Diclegis and Bonjesta the same?
              No, but they're very similar. Brand name Diclegis and Bonjesta are both combination medications that have the same active ingredients: doxylamine and pyridoxine (also known as vitamin B6). Diclegis tablets contain 10 mg of doxylamine and 10 mg of pyridoxine. But Bonjesta tablets contain double the amount (20 mg of doxylamine and 20 mg of pyridoxine). This means that you generally need to take less tablets with Bonjesta than with Diclegis (for example, 1 Bonjesta tablet at bedtime versus 2 Diclegis tablets at bedtime). In addition, Diclegis has a generic version available but Bonjesta doesn't. You can discuss with your precriber about comparing the two medications and seeing which option is right for you.
              What's the difference between Bonjesta and Zofran?
              Bonjesta (doxylamine / pyridoxine) and ondansetron (Zofran) are two different medications for helping with nausea and vomiting in different situations. Bonjesta is FDA approved for treating morning sickness during pregnancy. On the other hand, ondansetron (Zofran) is approved for preventing nausea and vomiting from certain cancer therapies and surgery. But some healthcare professionals prescribe ondansetron (Zofran) off-label for morning sickness. Although Bonjesta is proven to be safe during pregnancy, it's not clear for ondansetron (Zofran). Keep in mind that the American College of Obstetricians and Gynecologists (ACOG) recommends Bonjesta as an option for morning sickness but doesn't recommend ondansetron (Zofran) as a first-choice option. Speak with your prescriber about your options for morning sickness during pregnancy.
              Can I take doxylamine and pyridoxine separately instead of Bonjesta (doxylamine / pyridoxine)?
              Yes. In fact, the American College of Obstetricians and Gynecologists (ACOG) recommends pyridoxine (another name for vitamin B6) by itself as a first-choice option for morning sickness. If you need more relief, it's recommended that you add on doxylamine or switch to Bonjesta (doxylamine / pyridoxine). If you take the two separately, a common dose is 10 mg to 25 mg of pyridoxine, with or without 12.5 mg of doxylamine, three to four times a day. You can find pyridoxine and doxylamine over the counter as single-ingredient products. Note that doxylamine comes as 25 mg tablets only, so you'll need to cut them in half with a pill splitter for your doses. Ask a healthcare professional about whether this option is right for you instead of Bonjesta (doxylamine / pyridoxine).
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              What are the risks and warnings for Bonjesta (doxylamine / pyridoxine)?

              Bonjesta (doxylamine / pyridoxine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Sleepiness

              • Risk factors: Taking medications that can make you sleepy | Drinking alcohol

                Bonjesta (doxylamine / pyridoxine) can make you sleepy. Avoid driving, operating heavy machinery, or doing anything that you need concentration for while you're taking this medication until you speak with your prescriber. This helps prevent accidental injuries, especially since Bonjesta (doxylamine / pyridoxine) can affect your ability to think clearly and react quickly. Discuss with your care team about how the medication makes you feel after you take it.

                Bonjesta (doxylamine / pyridoxine) isn't recommended if you're currently taking other medications that can make you sleepy, such as sleep or anxiety medications, or if you drink alcohol. Mixing Bonjesta (doxylamine / pyridoxine) with these medications or with alcohol can lead to severe sleepiness, which can lead to falls or accidents.

                risk-warning

                Worsening of certain other medical conditions

                Because of how Bonjesta (doxylamine / pyridoxine) works and its possible side effects, this medication can worsen symptoms of certain other medical conditions. Examples include high pressure in the eye, narrow-angle glaucoma, stomach ulcers, gut blockage, and problems with urination. Let your care team know about your full medical history before you start taking Bonjesta (doxylamine / pyridoxine) so they can discuss risks and benefits.

                Contact your primary care provider or care team if you notice any symptoms of your other medical conditions get worse while you're taking Bonjesta (doxylamine / pyridoxine).

                dosage

                Bonjesta (doxylamine / pyridoxine) dosage forms

                The average cost for 60 tablets of 20mg/20mg of Bonjesta (doxylamine / pyridoxine) is $199.20 with a free GoodRx coupon. This is 76.35% off the average retail price of $842.43.
                tablet
                Tablet
                DosageQuantityPrice as low asPrice per unit
                20mg/20mg60 tablets$199.20$3.32

                Typical dosing for Bonjesta (doxylamine / pyridoxine)

                Each tablet contains 20 mg of doxylamine and 20 mg of pyridoxine.

                The typical dose is 1 tablet by mouth at bedtime on an empty stomach.

                • If your symptoms don't get better after the second day of taking the medication, you can take 1 tablet by mouth in the morning and then 1 tablet at bedtime.

                The maximum number of tablets you can take in a day is 2 tablets.

                interactions

                Interactions between Bonjesta (doxylamine / pyridoxine) and other drugs

                Bonjesta (doxylamine / pyridoxine) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Bonjesta (doxylamine / pyridoxine). Please note that only the generic name of each medication is listed below.

                Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                How much does Bonjesta (doxylamine / pyridoxine) cost?

                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
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                Bonjesta (doxylamine / pyridoxine) contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Bonjesta (doxylamine / pyridoxine) will not be safe for you to take.
                alternatives

                What are alternatives to Bonjesta (doxylamine / pyridoxine)?

                There are a number of medications that your doctor can prescribe in place of Bonjesta (doxylamine / pyridoxine). Compare a few possible alternatives below.
                Bonjesta (doxylamine / pyridoxine)
                Used for:
                • Morning sickness (nausea and vomiting during pregnancy) when non-medication options haven't provided enough relief

                $199.20 Lowest GoodRx priceView Prices
                Used for:
                • Morning sickness (nausea and vomiting during pregnancy) when non-medication options haven't provided enough relief

                $56.78 Lowest GoodRx priceView Prices
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                Bonjesta (doxylamine / pyridoxine) images

                Pink Round Logo And D - Bonjesta 20mg-20mg Extended-Release Tablet
                This medicine is Pink, Round Tablet Imprinted With "Logo" And "D".Pink Round Logo And D - Bonjesta 20mg-20mg Extended-Release Tablet

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                References

                Best studies we found

                American College of Obstetricians and Gynecologists. (2023). Morning sickness: Nausea and vomiting of pregnancy.

                American Optometric Association. (n.d.). Ocular hypertension.

                Dormuth, C. R., et al. (2021). Comparison of pregnancy outcomes of patients treated with ondansetron vs alternative antiemetic medications in a multinational, population-based cohort. Journal of the American Medical Association Network Open.

                View All References (6)
                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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