Stribild vs Genvoya: Is There a Better Option for HIV?

Roni Shye
Roni Shye, PharmD BCGP BCACP, is a licensed pharmacist in the states of Florida, Ohio, and Pennsylvania.
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You may remember that HIV and AIDS treatment back in the 1980s, 1990s, and even the early 2000s required several different pills. Many of these pills were large and difficult to swallow, and caused a lot of side effects like nausea and vomiting. Today, advancements in the management of HIV can mean treatment with as little as one pill.

Both Stribild and Genvoya offer a combination of four different medications, available as a single pill, for the treatment of HIV.

What medications are in Stribild and Genvoya?
Stribild is a combination of four medications:

Genvoya is also combination of four (very similar) medications:

What are Stribild and Genvoya used for?
Stribild and Genvoya are indicated for the treatment of HIV-1 in adults.

There are two main types of HIV, HIV-1 and HIV-2, and HIV-1 is the most widespread type of the virus worldwide.

Are there advantages to using either Genvoya or Stribild?

Remember those very similar active ingredients? Genvoya contains tenofovir alafenamide, while Stribild has tenofovir disoproxil fumarate.

Tenofovir alafenamide (in Genvoya) is easier on your kidneys and bones, compared to tenofovir disoproxil fumarate (in Stribild). This means that Genvoya is less likely to cause kidney or bone damage.

Are there any disadvantages to using Genvoya?

Potentially, cost. Genvoya’s estimated annual cost is $31,362. This is similar to Stribild, which estimated to cost $28,500 annually—but Genvoya does tend to be slightly more expensive.

Which one will my insurance cover?

Unfortunately, there’s a lot of variation in coverage from plant to plan, so it may be hard to make a blanket statement about which medication is more likely to be covered by your particular insurance. You’ll want to check with your plan to see if Stribild and/or Genvoya will be covered for you.

Is there financial assistance available for either Stribild or Genvoya?

Gilead is the manufacturer of both Stribild and Genvoya. They have several programs in place to help reduce the financial burden of these medications.

For more information, check out their patient assistance website here.

There are also many companies and organizations out there that work to reduce to cost and increase the availability of HIV medications for patients, regardless of which medication you’ve been prescribed. You may want to check with an organization like to find out which programs are available to you.

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