The FDA temporarily allowed compounded GLP-1 (glucagon-like peptide-1 receptor agonist) injections starting in 2022. This was due to a shortage of semaglutide (Ozempic, Wegovy), followed by tirzepatide (Mounjaro, Zepbound). Now that the shortages have been resolved, you may need to switch to a branded GLP-1.
The right GLP-1 for you may depend on many factors, and there may be more options than you realize, according to Stacia Woodcock, PharmD, Pharmacy Editor at GoodRx.
The three branded versions of semaglutide include:
Ozempic (for Type 2 diabetes in adults)
Rybelsus (for Type 2 diabetes in adults)
Wegovy (for chronic weight management in adults and children ages 12 and up)
Rybelsus is currently the only oral GLP-1 medication. The other GLP-1 options are injectable.
Both Ozempic and Wegovy also have benefits for the heart in certain people with heart disease. And Ozempic can protect the kidneys in people with both Type 2 diabetes and chronic kidney disease.
Tirzepatide is a related class of medications called GIP/GLP-1 receptor antagonists. It works similarly to GLP-1 medications, but it targets two gut hormones (GIP and GLP-1) instead of just one.
Branded options for tirzepatide include:
“Zepbound is also approved to treat obstructive sleep apnea in adults who are considered obese,” says Woodcock.
Brand options for liraglutide include:
Victoza (for Type 2 diabetes in adults and children ages 10 and older)
Saxenda (for chronic weight management in adults and children ages 12 and older)
“Victoza is also approved to reduce the risk of [heart attacks and other cardiovascular events] in adults living with Type 2 diabetes and heart-related conditions,” says Woodcock.
The only brand option for dulaglutide is Trulicity. “It's approved for Type two diabetes in adults and children ages 10 and older,” says Woodcock.
Trulicity also has cardiovascular risk-reduction benefits in certain people who have Type 2 diabetes.
Remember, the right option for you depends on many factors, such as your health history, lifestyle, preferences, budget, and more. Plus, new options are in the pipeline, and current options may be approved to treat other conditions.
Talk to your healthcare team. “They'll help you figure out which GLP-1 medication is the right fit for you and is most likely to be covered by your insurance,” says Woodcock.
This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. GoodRx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. GoodRx provides no warranty for any information. Please seek medical advice before starting, changing or terminating any medical treatment.
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