The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
B-cell precursor ALL with MRD:
- Fever (91%)
- Infusion-related reactions (77%)
- Headache (39%)
- Infections (39%)
- Tremor (31%)
- Chills (28%)
B-cell precursor ALL that’s come back or not responded to treatment:
- Fever (55%)
- Low white blood cell count (31%)
- Infusion-related reactions (30%)
- Infection (28%)
- Low red blood cell count (25%)
- Headache (23%)
- Low platelet count (21%)
B-cell precursor ALL in consolidation phase:
- Low white blood cell count (up to 82%)
- Fever (76%)
- Low platelets (75%)
- Low red blood cell count (up to 59%)
- Nausea (up to 43%)
- Headache (up to 41%)
- Infection (up to 35%)
- Diarrhea (29%)
- Tremor (23%)
- Muscle and bone pain (up to 23%)
- Rash (22%)
Less Common Side Effects
B-cell precursor ALL with MRD:
- Trouble sleeping
- Low white blood cell count
- Low platelets
- Low blood pressure
- Dizziness
- Rash
- Cough
- Back pain
- Weight gain
- Speech problems
- Confusion
- High liver enzymes
B-cell precursor ALL that’s come back or not responded to treatment:
- Swelling
- High liver enzymes
- Irregular heartbeat
- Rash
B-cell precursor ALL in consolidation phase:
- High blood pressure
- Trouble speaking
- Stomach pain
- Bleeding
- Mouth sores
- High liver enzymes
Blincyto serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Cytokine release syndrome (CRS): fever, tiredness, dizziness, headache, nausea, vomiting, chills, face swelling, trouble breathing, skin rash
- Nervous system problems: seizures, trouble speaking, fainting, trouble sleeping, confusion, balance problems, headache, difficulty seeing, tremors
- Serious infection: fever, chills, weakness, cough, shortness of breath, sore throat
- Tumor lysis syndrome: nausea, vomiting, confusion, shortness of breath, irregular heartbeat, dark or cloudy urine, urinating less often, tiredness, muscle cramps
- Inflammation of the pancreas (pancreatitis): severe stomach pain, nausea, vomiting
Source: DailyMed
The following Blincyto side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Fever, chills, unusual weakness or fatigue, loss of appetite, nausea, headache, dizziness, feeling faint or lightheaded, shortness of breath, fast or irregular heartbeat, which may be signs of cytokine release syndrome
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Pain, tingling, or numbness in the hands or feet, muscle weakness, change in vision, confusion or trouble speaking, loss of balance or coordination, trouble walking, seizures
- Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
- Tumor lysis syndrome (TLS)—nausea, vomiting, diarrhea, decrease in the amount of urine, dark urine, unusual weakness or fatigue, confusion, muscle pain or cramps, fast or irregular heartbeat, joint pain
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Headache
- Swelling of the ankles, hands, or feet
- Tremors or shaking
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