betamethasone injection
Betamethasone injection, also known by its brand name Celestone Soluspan, is an injectable steroid that helps reduce inflammation from various conditions. It combines two different forms of betamethasone: betamethasone sodium phosphate and betamethasone acetate. It's typically used when people can't take steroid medications by mouth, and must be injected by a healthcare professional (HCP). This injection is approved for both adults and children, but it's not known if it's safe during pregnancy. Common side effects of steroids include high blood sugar, sleep problems, and mood changes.
What is Betamethasone (Celestone Soluspan)?
What is Betamethasone (Celestone Soluspan) used for?
This medication is used for many different conditions. Generally, it's used for autoimmune problems, conditions related to swelling, or cancer. Some examples include:
- Allergies or allergic reactions
- Skin conditions
- Conditions affecting certain hormones (e.g., low adrenal hormones)
- Gut conditions (e.g., ulcerative colitis)
- Conditions related to blood cells
- Certain cancers (e.g., leukemia)
- Nervous system conditions (e.g., multiple sclerosis)
- Eye conditions
- Kidney conditions
- Lung conditions
- Joint conditions (e.g., rheumatoid arthritis)
- Lupus
How Betamethasone (Celestone Soluspan) works
Betamethasone (Celestone Soluspan) is a corticosteroid. It can be used for many conditions by reducing the release of chemicals in your body that cause swelling and inflammation.
Drug facts
| Common Brands | Celestone Soluspan |
|---|---|
| Drug Class | Corticosteroid |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Betamethasone (Celestone Soluspan)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Acne
- Skin thinning
- High blood sugar
- Swelling
- Stomach bloating
- Nausea
- Muscle problems or weakness
Less Common Side Effects
- Mood changes
- Vision changes
- Infection
- Hiccups
- Lower amount of sperm
- Weakness
- Swelling on face
- Weight gain
Betamethasone (Celestone Soluspan) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction: hives, difficulty breathing, difficulty swallowing, swelling of the face, lips, tongue, or throat
- Heart failure: shortness of breath, swelling in the arms and legs, sudden weight gain, tiredness, dizzy, poor appetite, nausea
- Infection: fever, chills, muscle aches, constant cough, sore throat, skin redness or swelling, diarrhea, burning feeling during urination
- Extreme mood swings and severe depression
More on Betamethasone (Celestone Soluspan) side effects
The following Betamethasone (Celestone Soluspan) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Cushing syndrome—increased fat around the midsection, upper back, neck, or face, pink or purple stretch marks on the skin, thinning, fragile skin that easily bruises, unexpected hair growth
- High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
- Increase in blood pressure
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
- Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
- Stomach bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds
- Swelling of the ankles, hands, or feet
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Acne
- General discomfort and fatigue
- Headache
- Increase in appetite
- Nausea
- Trouble sleeping
- Weight gain
Pros and cons of Betamethasone (Celestone Soluspan)
Pros
- Works well to treat many different conditions involving the immune system
- A good option for people who can't take medications by mouth
- Safe for children and adults
- Can be injected directly into the problem area
Cons
- Must be given by a healthcare professional (HCP)
- Can cause side effects like upset stomach, mood changes, and sleep problems
- Can weaken the immune system, leading to higher risk of infections
- Might need to taper your dose before stopping
Pharmacist tips for Betamethasone (Celestone Soluspan)
- Betamethasone (Celestone Soluspan) can interact with many medications, including warfarin (Coumadin), macrolide antibiotics, and certain birth control pills. Tell your prescriber about all medications and supplements you're taking to avoid serious interactions.
- Don't stop taking betamethasone (Celestone Soluspan) suddenly without talking to your prescriber because it can cause serious problems with hormone levels. If you need to stop, you'll likely need to lower your dose slowly over time to prevent side effects such as weakness, nausea, and joint pain.
- Let your HCP know if you develop a fever, cough, body aches, chills, or other signs of an infection while taking betamethasone (Celestone Soluspan). This medication lowers your immune system so you might have a more difficult time fighting off infections.
- Avoid contact with people with chickenpox or measles, as these infections can cause serious problems while you're receiving betamethasone (Celestone Soluspan). Let your prescriber know if you’ve been exposed to these viruses.
- Make sure you're up to date with all of your vaccinations before starting betamethasone (Celestone Soluspan). This medication can make some vaccines not work well and it also raises your risk of getting sick from live vaccines. Avoid receiving vaccines during treatment until you discuss it with your prescriber.
- Betamethasone (Celestone Soluspan) might cause birth defects and hormone problems in unborn babies if given during pregnancy. It can also pass into breast milk and cause side effects in breastfed babies. Speak with your HCP about the risks and benefits before receiving betamethasone (Celestone Soluspan) during pregnancy or breastfeeding.
- Let your HCP know if you experience any mood or behavior changes while taking betamethasone (Celestone Soluspan). This medication can cause extreme mood swings and severe depression.
Risks and warnings for Betamethasone (Celestone Soluspan)
Betamethasone (Celestone Soluspan) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Nerve problems
- Risk factors: Epidural injection | Intrathecal injection | High doses of betamethasone (Celestone Soluspan)
Injecting betamethasone (Celestone Soluspan) into the intrathecal (fluid-filled space around the brain and spinal cord) or epidural area (space around the spinal nerves in your lower back) can raise the risk of nerve problems. These problems can include stroke within the spinal cord or arteries leading to the spinal cord, paralysis of the lower half of the body, paralysis from the neck down, vision loss, stroke, or even death. That's why betamethasone (Celestone Soluspan) shouldn't be injected into these areas.
High doses of betamethasone (Celestone Soluspan) can also raise the risk of sudden myopathy (serious muscle problems), such as muscle cramps or weakness, in people with a history of nerve conditions (e.g., myasthenia gravis) or who are taking neuromuscular blocking medications. Recovery might take weeks or years after stopping betamethasone (Celestone Soluspan). The sudden myopathy can affect the eyes, lungs, or lead to paralysis from the neck down, so let your HCP know if you experience muscle weakness, breathing problems, or vision changes while taking this medication.
Reduced adrenal gland function
- Risk factors: Stopping betamethasone (Celestone Soluspan) suddenly | Stress such as trauma, injury, or infection
Your adrenal gland makes certain hormones for your body, but long-term use of betamethasone (Celestone Soluspan) injections can cause adrenal insufficiency. This is when your adrenal glands stop making hormones naturally. Stopping the medication suddenly can lead to steroid withdrawal, causing tiredness, joint or muscle pain, and low energy. Hormone problems can occur months after stopping betamethasone (Celestone Soluspan), so continue to follow up with your HCP even after stopping this medication.
Heart and electrolyte problems
- Risk factors: Large doses of corticosteroids | Recent heart attack | Heart failure | High blood pressure | Kidney problems
Corticosteroids like betamethasone (Celestone Soluspan) can increase blood pressure, raise salt and water levels, and lower potassium and calcium levels. Speak with your prescriber before starting betamethasone (Celestone Soluspan) if you have high blood pressure or a history of heart or kidney problems to make sure this medication is safe for you. Your prescriber will monitor you for any swelling in your legs and feet, and might ask you to limit the amount of salt you eat or take potassium supplements during your treatment.
Greater risk of infections
- Risk factors: Taking other medications that weaken your immune system | High doses of betamethasone (Celestone Soluspan) | Coming into contact with people who have viral illnesses | Receiving live vaccines
Corticosteroids like betamethasone (Celestone Soluspan) can weaken your immune system and raise your risk of getting infections. The medication can cause new infections, reactivate old ones, or hide symptoms of current infections. If you have an infection, speak with your HCP about treating it before starting betamethasone (Celestone Soluspan). Certain infections, like fungal, parasitic, tuberculosis, chickenpox, or measles, can worsen and lead to serious complications if corticosteroids are taken at the same time. Let your prescriber know right away if you experience any signs of infection, such as fever, cough, flu-like symptoms, stomach pain, vision problems, or diarrhea.
Injecting betamethasone (Celestone Soluspan) into a joint (intra-articular) can sometimes damage the joints or cause an infection in your joint fluid (septic arthritis). Don't get betamethasone (Celestone Soluspan) injected into joints that are currently or were previously infected. If you have pain, swelling, fever, weakness, or you're unable to move your joints freely, let your care team know right away. You might need antibiotics to treat the infection.
Eye problems
- Risk factors: Long-term use of betamethasone (Celestone Soluspan)
Betamethasone (Celestone Soluspan) can raise the risk of certain eye problems, such as cataracts, glaucoma, high eye pressure, eye nerve damage, or eye infections. If you're receiving this medication longer than 6 weeks, you might need to get your eyes checked regularly. Let your healthcare team know if you experience any vision changes.
Stomach problems
- Risk factors: Stomach ulcer | Stomach inflammation | Stomach surgery | Ulcerative colitis
Betamethasone (Celestone Soluspan) might raise your risk of developing a tear in the stomach if you have a history of stomach ulcers, ulcerative colitis, or other stomach inflammation and infections. Although signs of stomach irritation might be more difficult to recognize while taking betamethasone (Celestone Soluspan), let your HCP know if you experience any stomach pain or tenderness.
Bone problems
- Risk factors: Children | Women who've gone through menopause
Corticosteroids like betamethasone (Celestone Soluspan) can make your bones weak and brittle, which raises the risk of osteoporosis. Although the risk is higher in children and women who've gone through menopause, this can occur at any age. If this medication is given in children, it can affect their bones, growth, and development. Depending on how often you use this medication, your prescriber might need to check your bones regularly.
Changes in mood and behavior
- Risk factors: History of mental health conditions
Betamethasone (Celestone Soluspan) can sometimes affect your mood and behavior. It can affect your ability to sleep and cause mood swings, changes in your personality, and depression. If you have a history of mental health conditions, let your prescriber know, because betamethasone (Celestone Soluspan) can worsen these problems.
Cancer
- Risk factors: Long-term use
Although rare, there have been reports of people developing a type of cancer called Kaposi's sarcoma when taking corticosteroids like betamethasone (Celestone Soluspan) for a long time. Discuss the risk with your HCP if you're to take this medication long term.
Betamethasone (Celestone Soluspan) dosage
Typical dosage for Betamethasone (Celestone Soluspan)
Your healthcare professional (HCP) will determine your dose and how often you receive betamethasone (Celestone Soluspan) based on your condition, other health problems, and any medications you’re currently taking.
The typical starting dose is between 0.25 mg to 9 mg a day.
Betamethasone (Celestone Soluspan) can be given as an injection in various ways, including:
- Intrabursal: Into the fluid-filled sac between bones and muscles or tendons.
- Intra-articular: Into the joint.
- Intramuscular: Into the muscle.
- Intralesional: Into the lesion.
- Intradermal: Into the layers of the skin.
Betamethasone (Celestone Soluspan) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Betamethasone (Celestone Soluspan) will not be safe for you to take.
- Intramuscular (into the muscle) betamethasone (Celestone Soluspan) injection given to treat idiopathic thrombocytopenic purpura, a rare blood condition with low platelet levels
What are alternatives to Betamethasone (Celestone Soluspan)?
This medication is used for many different conditions. Generally, it's used for autoimmune problems, conditions related to swelling, or cancer. Some examples include:
This medication is used for many different conditions. Generally, it's used for autoimmune problems, conditions related to swelling, or cancer. Some examples include:
Methylprednisolone (Medrol) is used for many different medical conditions, including:
