Betamethasone injection, also known by its brand name Celestone Soluspan, is an injectable steroid that helps reduce inflammation from various conditions. It combines two different forms of betamethasone: betamethasone sodium phosphate and betamethasone acetate. It's typically used when people can't take steroid medications by mouth, and must be injected by a healthcare professional (HCP). This injection is approved for both adults and children, but it's not known if it's safe during pregnancy. Common side effects of steroids include high blood sugar, sleep problems, and mood changes.
This medication is used for many different conditions. Generally, it's used for autoimmune problems, conditions related to swelling, or cancer. Some examples include:
Betamethasone (Celestone Soluspan) is a corticosteroid. It can be used for many conditions by reducing the release of chemicals in your body that cause swelling and inflammation.
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Betamethasone (Celestone Soluspan) is an injectable steroid medication that's used when people can't take steroids by mouth. It works by blocking substances in the body that lead to inflammation. Some conditions it can be used to treat include allergies, ulcerative colitis, and multiple sclerosis.
How often you need a betamethasone (Celestone Soluspan) injection depends on your medical condition. This medication can provide relief for certain joint problems and restore full range of movement after one or a few injections. But some conditions might need daily injections or many injections over a period of time. Talk with your prescriber about how often you might need these injections.
An HCP will give the injection. Betamethasone (Celestone Soluspan) can be given as an injected in many ways, including intrabursal (into the fluid-filled sac between the bones and other muscles or tendons), intra-articular (into the joint), intramuscular (into the muscle), intralesional (into the lesion) or intradermal (into the layers of the skin). Speak to your prescriber about where you will receive this injection.
Using steroids like betamethasone (Celestone Soluspan) during pregnancy can pose a risk to your unborn baby. While there are no good studies on its use in pregnant people, animal studies have shown signs of birth defects. Tell your healthcare team if you’re pregnant or planning to become pregnant. Your prescriber will likely recommend this medication only if the benefits outweigh the risks to you and your baby.
Since betamethasone (Celestone Soluspan) is an injection, it might cause pain and other injection site reactions. If needed, ask your HCP about using numbing medications before your injections. They might be able to mix a numbing medication called lidocaine into the betamethasone (Celestone Soluspan) syringe to reduce injection pain.
Usually not. Long-term use of betamethasone (Celestone Soluspan) can make your body get used to the medication. Stopping it suddenly can cause withdrawal symptoms like fever, low appetite, nausea, weakness, joint pain, skin peeling, and weight loss. If you want or need to stop betamethasone (Celestone Soluspan) after long-term use, talk to your prescriber. They can help you gradually lower your dose to safely "wean off" the medication.
Betamethasone (Celestone Soluspan) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Injecting betamethasone (Celestone Soluspan) into the intrathecal (fluid-filled space around the brain and spinal cord) or epidural area (space around the spinal nerves in your lower back) can raise the risk of nerve problems. These problems can include stroke within the spinal cord or arteries leading to the spinal cord, paralysis of the lower half of the body, paralysis from the neck down, vision loss, stroke, or even death. That's why betamethasone (Celestone Soluspan) shouldn't be injected into these areas.
High doses of betamethasone (Celestone Soluspan) can also raise the risk of sudden myopathy (serious muscle problems), such as muscle cramps or weakness, in people with a history of nerve conditions (e.g., myasthenia gravis) or who are taking neuromuscular blocking medications. Recovery might take weeks or years after stopping betamethasone (Celestone Soluspan). The sudden myopathy can affect the eyes, lungs, or lead to paralysis from the neck down, so let your HCP know if you experience muscle weakness, breathing problems, or vision changes while taking this medication.
Your adrenal gland makes certain hormones for your body, but long-term use of betamethasone (Celestone Soluspan) injections can cause adrenal insufficiency. This is when your adrenal glands stop making hormones naturally. Stopping the medication suddenly can lead to steroid withdrawal, causing tiredness, joint or muscle pain, and low energy. Hormone problems can occur months after stopping betamethasone (Celestone Soluspan), so continue to follow up with your HCP even after stopping this medication.
Corticosteroids like betamethasone (Celestone Soluspan) can increase blood pressure, raise salt and water levels, and lower potassium and calcium levels. Speak with your prescriber before starting betamethasone (Celestone Soluspan) if you have high blood pressure or a history of heart or kidney problems to make sure this medication is safe for you. Your prescriber will monitor you for any swelling in your legs and feet, and might ask you to limit the amount of salt you eat or take potassium supplements during your treatment.
Corticosteroids like betamethasone (Celestone Soluspan) can weaken your immune system and raise your risk of getting infections. The medication can cause new infections, reactivate old ones, or hide symptoms of current infections. If you have an infection, speak with your HCP about treating it before starting betamethasone (Celestone Soluspan). Certain infections, like fungal, parasitic, tuberculosis, chickenpox, or measles, can worsen and lead to serious complications if corticosteroids are taken at the same time. Let your prescriber know right away if you experience any signs of infection, such as fever, cough, flu-like symptoms, stomach pain, vision problems, or diarrhea.
Injecting betamethasone (Celestone Soluspan) into a joint (intra-articular) can sometimes damage the joints or cause an infection in your joint fluid (septic arthritis). Don't get betamethasone (Celestone Soluspan) injected into joints that are currently or were previously infected. If you have pain, swelling, fever, weakness, or you're unable to move your joints freely, let your care team know right away. You might need antibiotics to treat the infection.
Betamethasone (Celestone Soluspan) can raise the risk of certain eye problems, such as cataracts, glaucoma, high eye pressure, eye nerve damage, or eye infections. If you're receiving this medication longer than 6 weeks, you might need to get your eyes checked regularly. Let your healthcare team know if you experience any vision changes.
Betamethasone (Celestone Soluspan) might raise your risk of developing a tear in the stomach if you have a history of stomach ulcers, ulcerative colitis, or other stomach inflammation and infections. Although signs of stomach irritation might be more difficult to recognize while taking betamethasone (Celestone Soluspan), let your HCP know if you experience any stomach pain or tenderness.
Corticosteroids like betamethasone (Celestone Soluspan) can make your bones weak and brittle, which raises the risk of osteoporosis. Although the risk is higher in children and women who've gone through menopause, this can occur at any age. If this medication is given in children, it can affect their bones, growth, and development. Depending on how often you use this medication, your prescriber might need to check your bones regularly.
Betamethasone (Celestone Soluspan) can sometimes affect your mood and behavior. It can affect your ability to sleep and cause mood swings, changes in your personality, and depression. If you have a history of mental health conditions, let your prescriber know, because betamethasone (Celestone Soluspan) can worsen these problems.
Although rare, there have been reports of people developing a type of cancer called Kaposi's sarcoma when taking corticosteroids like betamethasone (Celestone Soluspan) for a long time. Discuss the risk with your HCP if you're to take this medication long term.
Your healthcare professional (HCP) will determine your dose and how often you receive betamethasone (Celestone Soluspan) based on your condition, other health problems, and any medications you’re currently taking.
The typical starting dose is between 0.25 mg to 9 mg a day.
Betamethasone (Celestone Soluspan) can be given as an injection in various ways, including:
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Betamethasone (Celestone Soluspan) will not be safe for you to take.
This medication is used for many different conditions. Generally, it's used for autoimmune problems, conditions related to swelling, or cancer. Some examples include:
This medication is used for many different conditions. Generally, it's used for autoimmune problems, conditions related to swelling, or cancer. Some examples include:
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