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Xadago

Safinamide Mesylate

SAFINAMIDE is a monoamine oxidase inhibitor (MAOI). It is used to treat Parkinson's disease. Compare MAOIs.
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Xadago Side Effects

What should I watch for?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Do not stop this medicine suddenly. Ask your doctor or health care professional for advice about gradually reducing your dose.

You may get drowsy, dizzy, or have blurred vision. Do not drive, use machinery, work in high places, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase dizziness or drowsiness. Talk to your doctor before drinking alcoholic beverages while taking this medicine. It is possible to suddenly fall asleep or suddenly feel like falling asleep during usual activities of daily living (e.g., cooking, driving a car, talking on the phone, eating, working) while you are taking this medicine. This may result in having accidents, which can be severe. Your chances of falling asleep while doing normal activities and taking this medicine are greater if you take other medicines that cause drowsiness. If you find that you suddenly fall asleep or suddenly feel like falling asleep during usual daily activities, you should not drive or participate in potentially dangerous activities and you should contact your doctor right away. You should not drive, operate machinery, or work at heights during treatment with this medicine if you have ever experienced severe drowsiness and/or have fallen asleep without warning before using this medicine.

While taking this medicine, you may feel increased sexual urges, or other strong urges to gamble, spend money, or binge eat, and be unable to control these urges. If you or your family notice these or other strong urges while you are taking this medicine, you should report this to your health care provider as soon as possible.

Foods that contain very high amounts of tyramine, such as aged, fermented, cured, smoked and pickled foods, should be avoided while taking this medicine. The combination may cause a dangerous rise in blood pressure. Ask your doctor or health care professional, pharmacist, or nutritionist for a complete listing of foods and beverages that are high in tyramine. If you consume a food or beverage very rich in tyramine and do not feel well soon after eating, contact your health care provider.

Some medicines may interact with this medicine and could cause adverse effects. Talk to your doctor if you are taking or planning to take any over-the-counter drugs, especially cough remedies or decongestants, including nasal sprays or eye drops. This medicine may also interact with antidepressants and certain medicines for pain. Contact your health care provider before taking new medications including antidepressants, pain medicines, or prescription or over-the-counter medicines for congestion, cough, colds, or allergies.

If you are scheduled for any medical or dental procedure, tell your healthcare provider that you are taking this medicine. This medicine can interact with other medicines used during surgery.

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Side Effects to watch for

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • changes in vision
  • falls
  • hallucination, loss of contact with reality
  • high blood pressure
  • signs and symptoms of hypertensive crisis like severe headache with confusion and blurred vision, severe chest pain, shortness of breath, nausea and vomiting, seizures
  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired
  • signs and symptoms of serotonin syndrome like confusion, heavy sweating, fever, involuntary muscle jerking, tremor, rigid muscles, unstable blood pressure, diarrhea
  • suddenly falling asleep or sudden feelings of wanting to fall asleep during usual activities like driving or eating
  • uncontrolled, sudden body movements (dyskinesia)
  • unusual or obvious changes in behavior such as agitation, confusion, disorganized thinking

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

What may interact with this drug?

Do not take this medicine with any of the following medications:

This medicine may also interact with the following medications:

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