Skip to main content
Tranylcypromine

Tranylcypromine Side Effects

Hope Chang, PharmD, AAHIVPMichelle Nguyen, PharmD
Reviewed by Hope Chang, PharmD, AAHIVP, Michelle Nguyen, PharmD
Last reviewed on January 14, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dry mouth
  • Dizziness
  • Trouble sleeping
  • Sleepiness
  • Headache
  • Overexcitement
  • Constipation
  • Blurry vision
  • Tremor, shakiness

Less Common Side Effects

  • Loss of appetite, anorexia
  • Weight gain
  • Anxiety
  • Sexual dysfunction
  • Ringing in the ear
  • Fast heartbeat
  • Bladder problems
  • Fluid retention, bloating
  • Double vision
  • Poor coordination

Tranylcypromine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts or behavior
  • Serotonin syndrome: fast heart rate, sweating, muscle stiffness or spasms, fever, confusion
  • Dangerously high blood pressure: severe headache, changes in your heart rate, neck stiffness or soreness, nausea, vomiting
  • Liver damage: fever, rash, tiredness, nausea, vomiting, loss of appetite, yellowing of your eyes and skin
  • Low blood sugar: hunger, anxiety, trembling, shaking, sweating, feeling faint, feeling irritated
  • Seizures

Source: DailyMed

The following Tranylcypromine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Absence of or decrease in body movement

actions that are out of control

agitation

anxiety

black, tarry stools

bleeding gums

blood in the urine or stools

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain

chills

confusion

confusion about identity, place, and time

cough

dark urine

decrease in frequency of urination

decrease in urine volume

decreased awareness or responsiveness

depression

difficulty in passing urine (dribbling)

dizziness

dry mouth

fast, irregular, pounding, or racing heartbeat or pulse

fever with or without chills

general feeling of tiredness or weakness

headache

hoarseness

hostility

hyperventilation

increased need to urinate

irritability

light-colored stools

longer than usual time to ejaculation of semen

loss of bladder control

loss of consciousness

lower back or side pain

muscle twitching

nausea

nervousness

painful or difficult urination

pale skin

passing urine more often

pinpoint red spots on the skin

rapid weight gain

restlessness

seizures

severe sleepiness

shakiness and unsteady walk

sore throat

sores, ulcers, or white spots on the lips or in the mouth

sudden jerky movements of the body

swelling of the face, ankles, or hands

swollen glands

talking, feeling, and acting with excitement

trouble with sleeping

troubled breathing with exertion

unsteadiness, trembling, or other problems with muscle control or coordination

unusual bleeding or bruising

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

upper right abdominal pain

vomiting

yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Blurred vision

constipation

continuing ringing or buzzing or other unexplained noise in the ears

decreased interest in sexual intercourse

diarrhea

drowsiness

dry mouth

hair loss or thinning of the hair

hearing loss

hives or welts, itching, skin rash

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

loss of appetite

memory loss

muscle spasm

redness of the skin

stomach pain

unable to sleep

weakness

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Was this page helpful?