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Emsam

Emsam Side Effects

Kristianne Hannemann, PharmDDaisy Chau, PharmD
Reviewed by Kristianne Hannemann, PharmD, Daisy Chau, PharmD
Last reviewed on April 1, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Application site reactions (24%)
  • Headache (18%)
  • Trouble sleeping (12%)
  • Diarrhea (9%)
  • Dry mouth (8%)
  • Indigestion (4%)
  • Rash (4%)
  • Sinus infection (3%)
  • Sore throat (3%)

Less Common Side Effects

  • Sexual problems
  • Low blood pressure
  • Weight gain
  • Weight loss
  • Reduced appetite
  • Itchiness
  • High heart rate
  • Tremors

Emsam serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts and behavior
  • Serotonin syndrome: agitation, hallucinations, confusion, coma, fast heart rate, sudden changes in blood pressure, dizziness, sweating, blushing, high body temperature, tremor, stiffness, muscle jerks, seizures
  • Dangerously high blood pressure: chest pain, severe headaches, fast heartbeat, stiff or sore neck, nausea, vomiting, sweating, wide pupils, light sensitivity

Source: DailyMed

The following Emsam side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chills

cold sweats

confusion

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

Incidence not known

Confusion about identity, place, and time

seeing things that are not there

seizures

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Burning, itching, redness, skin rash, swelling, or soreness where the patch was placed

diarrhea

dry mouth

headache

trouble sleeping

Less common

Belching

body aches or pain

change or problem with discharge of semen

congestion

cough

dryness or soreness of the throat

fever

heartburn

hoarseness

indigestion

pain or tenderness around the eyes and cheekbones

rash

runny nose

stomach discomfort, upset, or pain

stuffy or runny nose

tender, swollen glands in the neck

tightness of the chest

trouble swallowing

troubled breathing

voice changes

weight changes

Rare

Decreased interest in sexual intercourse

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

not able to have an orgasm

Incidence not known

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

tension

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.
Daisy Chau, PharmD
Reviewed by:
Daisy Chau, PharmD
Daisy Chau, PharmD, is the drug information pharmacist manager at GoodRx. She is licensed in California and has more than 6 years of experience working as a pharmacist in drug information.

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