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Marplan

Marplan Side Effects

Robert Chad Hakim, PharmD, BCCCPCydnee Ng, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Cydnee Ng, PharmD
Last reviewed on April 21, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dizziness (29%)
  • Headache (15%)
  • Dry mouth (9%)
  • Constipation (7%)
  • Nausea (6%)
  • Sleep problems (5%)

Less Common Side Effects

Marplan serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts or behaviors
  • Extremely high blood pressure: seizure, chest pain, severe headache, frequent headaches, confusion, blurry vision, anxiety, trouble breathing
  • Serotonin syndrome: hallucinations, seizure, confusion, restlessness, shivering, sweating, high fever, headache, racing heart, muscle stiffness or twitching, tremor

Source: DailyMed

The following Marplan side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chills

cold sweats

confusion

difficult urination

dizziness, faintness, or lightheadedness when getting up from lying or sitting position

fainting

fast, irregular, pounding, or racing heartbeat or pulse

fear or nervousness

heavy feeling

increased need to urinate

passing urine more often

restlessness

shakiness in the legs, arms, hands, or feet

sudden jerky movements of the body

sweating

trembling or shaking of the hands or feet

trouble sitting still

Incidence not known

Agitation

burning while urinating

change in consciousness

decrease in frequency of urination

decrease in urine volume

decreased urine output

depression

difficulty in passing urine (dribbling)

dizziness

false or unusual sense of well-being

headache

hostility

irritability

loss of bladder control

loss of consciousness

muscle twitching

nausea

need to keep moving

numbness or tingling of the hands, feet, or face

rapid weight gain

seeing, hearing, or feeling things that are not there

seizures

shakiness and unsteady walk

stupor

swelling of the face, ankles, or hands

unsteadiness, trembling, or other problems with muscle control or coordination

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Decreased interest in sexual intercourse

drowsiness

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

relaxed and calm

sleepiness

sleeplessness

trouble sleeping

unable to sleep

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Incidence not known

Black tongue

blurred vision

change in vision

impaired vision

increased sensitivity of the skin to sunlight

itching

raised, dark red, wart-like spots on the skin, especially when used on the face

redness or other discoloration of the skin

severe sunburn

skin rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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