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Marplan

Isocarboxazid

ISOCARBOXAZID is an monoamine oxidase inhibitor (MAOI). It is used to treat depression. Compare MAOIs.
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Marplan Side Effects

What should I watch for?

Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor.

This medicine can interact with certain foods that contain tyramine. The combination may cause severe headaches, a rise in blood pressure, or irregular heart beat. Foods that contain significant amounts of tyramine include aged cheeses, meats and fish (especially aged, smoked, pickled, or processed such as bologna, pepperoni, salami, summer sausage), beer and ale, alcohol-free beer, wine (especially red), sherry, hard liquor, liqueurs, avocados, bananas, figs, raisins, soy sauce, miso soup, yeast/protein extracts, bean curd, fava or broad bean pods, or any over-ripe fruit. Ask your doctor or health care professional, pharmacist, or nutritionist for a complete listing of tyramine-containing foods. Also, avoid drinks containing caffeine, such as tea, coffee, chocolate, or cola. After stopping this medicine, ask your health care professional how long you should continue avoiding these foods and drinks.

Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Do not take any medications for weight loss without your doctor's approval. Some ingredients in these products may increase possible side effects.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

Tell your health care professional that you are taking this medicine if you are scheduled to have any surgery, procedure or medical testing. You should usually stop taking this drug at least 10 days before elective surgery.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chills

cold sweats

confusion

difficult urination

dizziness, faintness, or lightheadedness when getting up from lying or sitting position

fainting

fast, irregular, pounding, or racing heartbeat or pulse

fear or nervousness

heavy feeling

increased need to urinate

passing urine more often

restlessness

shakiness in the legs, arms, hands, or feet

sudden jerky movements of the body

sweating

trembling or shaking of the hands or feet

trouble sitting still

Incidence not known

Agitation

burning while urinating

change in consciousness

decrease in frequency of urination

decrease in urine volume

decreased urine output

depression

difficulty in passing urine (dribbling)

dizziness

false or unusual sense of well-being

headache

hostility

irritability

loss of bladder control

loss of consciousness

muscle twitching

nausea

need to keep moving

numbness or tingling of the hands, feet, or face

rapid weight gain

seeing, hearing, or feeling things that are not there

seizures

shakiness and unsteady walk

stupor

swelling of the face, ankles, or hands

unsteadiness, trembling, or other problems with muscle control or coordination

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Decreased interest in sexual intercourse

drowsiness

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

relaxed and calm

sleepiness

sleeplessness

trouble sleeping

unable to sleep

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Incidence not known

Black tongue

blurred vision

change in vision

impaired vision

increased sensitivity of the skin to sunlight

itching

raised, dark red, wart-like spots on the skin, especially when used on the face

redness or other discoloration of the skin

severe sunburn

skin rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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