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Phenelzine

Phenelzine Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on December 10, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dizziness
  • Headache
  • Drowsiness
  • Sleep problems (too tired or trouble sleeping)
  • Tiredness
  • Weakness
  • Shakiness (tremors)
  • Twitching
  • Overactive reflexes
  • Constipation
  • Stomach upset
  • Dry mouth
  • Weight gain
  • Low blood pressure when you stand up
  • Swelling
  • Sexual health problems (e.g., erectile dysfunction, problems with orgasms)

Less Common Side Effects

  • Blurry vision
  • Eye movements that you can't control
  • Itchiness
  • Sweating
  • Feeling jittery
  • Numbness or tingling
  • Repeating your words
  • Bladder problems

Phenelzine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts or behaviors
  • Extremely high blood pressure: seizure, chest pain, severe headache, frequent headaches, confusion, blurry vision, anxiety, trouble breathing
  • Serotonin syndrome: hallucinations, seizure, confusion, restlessness, shivering, sweating, high fever, headache, racing heart, muscle stiffness or twitching, tremor

Source: DailyMed

The following Phenelzine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chills

cold sweats

confusion

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position

overactive reflexes

shakiness in the legs, arms, hands, or feet

sudden jerky movements of the body

swelling

trembling or shaking of the hands or feet

Less common

Abdominal or stomach pain

actions that are out of control

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in consciousness

clay-colored stools

dark urine

decrease in frequency of urination

decrease in urine volume

difficult or troubled breathing

difficulty in passing urine (dribbling)

disorganized thoughts

dizziness

drowsiness

false or unusual sense of well-being

fast, pounding, or irregular heartbeat or pulse

fear or nervousness

fever

general feeling of discomfort, illness, or weakness

headache

high blood pressure

increased sweating

irregular, fast or slow, or shallow breathing

irritability

itching

lack of emotion or feelings

loss of appetite

loss of consciousness

loud or fast speech

low blood pressure

muscle tremors

muscle twitching

nausea or vomiting

nervousness

no emotion or expression in speech

painful urination

pale or blue lips, fingernails, or skin

rapid, deep, or shallow breathing

rash

restlessness

seeing or hearing things that are not there

seizures

shakiness and unsteady walk

shortness of breath

slow or irregular heartbeat

stomach cramps

sweating

swelling of the feet or lower legs

talking, feeling, and acting with excitement

uncontrolled eye movements

unpleasant breath odor

unsteadiness, trembling, or other problems with muscle control or coordination

unusual paleness

unusual tiredness or weakness

vomiting of blood

weakness

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Constipation

decreased interest in sexual intercourse

diarrhea

dry mouth

inability to have or keep an erection

indigestion

loss in sexual ability, desire, drive, or performance

loss of appetite

not able to have an orgasm

passing of gas

sleeplessness

stomach pain, fullness, or discomfort

trouble sleeping

unable to sleep

unusually deep sleep

unusually long duration of sleep

weight gain

Less common

Blindness

blurred vision

decreased vision

eye pain

redness, swelling, or soreness of the tongue

tearing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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