6 Chlorthalidone Interactions to Consider
Here are the chlorthalidone interactions to be aware of and what to look out for if you’re taking a medication that interacts with it.
Thalitone
Used for Hypertension
Used for Hypertension
Thalitone (chlorthalidone) is a type of diuretic, or water pill. It's used to treat high blood pressure in adults. It's also used with other medications to help reduce swelling and fluid buildup from conditions like heart failure or kidney problems. Thalitone (chlorthalidone) is taken by mouth once a day. It can cause side effects like urinating more often, dizziness, and headache.
What is Thalitone (chlorthalidone)?
What is Thalitone (chlorthalidone) used for?
- High blood pressure
- Swelling from fluid buildup (edema) caused by heart failure, liver problems, or kidney problems
How Thalitone (chlorthalidone) works
Thalitone (chlorthalidone) is a thiazide-like diuretic, which is a type of water pill. It works in the kidneys to remove extra water and certain electrolytes from your body. It makes you urinate out the extra water and electrolytes. This helps lower your blood pressure and reduce swelling in the body.
When does Thalitone (chlorthalidone) start working?Time passed since treatment started:
Drug facts
| Common Brands | Thalitone |
|---|---|
| Drug Class | Thiazide-like diuretic |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
More on Thalitone (chlorthalidone) essentials
Side effects of Thalitone (chlorthalidone)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Urinating more
- Dizziness
- Headache
Less Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Stomach cramps
- Muscle spasm
- Weakness
- Skin that's sensitive to the sun
- Rash
Thalitone (chlorthalidone) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Allergic reaction: trouble breathing; swelling of the mouth, tongue, or throat; rash; hives
- Kidney problems: not urinating as often as usual, feeling tired, confusion
- Abnormal electrolyte levels: very thirsty, tired, weak, confused, muscle cramps or pain, muscle twitching, nausea, vomiting, fast heartbeat
When do Thalitone (chlorthalidone) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Urinating more
Dizziness
Headache
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.
More on Thalitone (chlorthalidone) side effects
The following Thalitone (chlorthalidone) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
Abdominal or stomach pain
black, tarry stools
bleeding gums
blistering, peeling, or loosening of the skin
blood in the urine or stools
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chills
clay-colored stools
cold sweats
confusion
cough or hoarseness
coughing up blood
darkened urine
difficulty having a bowel movement (stool)
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fast heartbeat
flushed, dry skin
fruit-like breath odor
general feeling of tiredness or weakness
headache
increased hunger
increased thirst
increased urination
indigestion
itching or skin rash
joint pain, stiffness, or swelling
loss of appetite
lower back or side pain
pain in the joints or muscles
painful or difficult urination
pains in the stomach, side, or abdomen, possibly radiating to the back
pinpoint red spots on the skin
red, irritated eyes
red skin lesions, often with a purple center
redness, soreness or itching skin
sores, ulcers, or white spots on the lips or in the mouth
sores, welting, or blisters
sugar in the urine
sweating
swelling of the feet or lower legs
swollen glands
tightness in the chest
troubled breathing
unpleasant breath odor
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight loss
vomiting
vomiting of blood
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Cramping
decreased interest in sexual intercourse
feeling of constant movement of self or surroundings
inability to have or keep an erection
increased sensitivity of the skin to sunlight
loss in sexual ability, desire, drive, or performance
redness or other discoloration of the skin
restlessness
sensation of spinning
severe sunburn
weakness
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$134.89
GoodRx discount
$118.67
Pros and cons of Thalitone (chlorthalidone)
Pros
- Taken just once a day
- A first-choice option for high blood pressure
- Can take by itself or with other blood pressure medications
Cons
- Can cause more urination and affect your electrolyte levels
- Can make your skin more sensitive to the sun
- Might not be the best choice if you have gout or an allergy to "sulfa drugs"
Pharmacist tips for Thalitone (chlorthalidone)
- Take Thalitone (chlorthalidone) with food. It's a good idea to take it earlier in the day, like in the morning. This medication makes you urinate more. If you take it later, like close to bedtime, you might have to wake up often at night to use the bathroom.
- Thalitone (chlorthalidone) can lower your blood pressure, which can make you feel dizzy. You might be at more of a risk if you're dehydrated or if you follow a low-sodium diet. If you feel dizzy, especially after standing up, sit down until it goes away to prevent falls. Tell your care team if the dizziness bothers you or doesn't go away.
- Try to limit or avoid alcohol while taking Thalitone (chlorthalidone). Alcohol can make dizziness worse and raise your risk of falling and getting hurt. Speak with your care team about how much you usually drink and how to take this medication safely.
- If you take Thalitone (chlorthalidone) to help with blood pressure, check your blood pressure often. Keep a record of your readings and share them with your care team. This helps your prescriber see how well the medication is working. If needed, they can make changes to your treatment plan to control your blood pressure better.
- Be sure to go to all your lab visits when your prescriber tells you to. Thalitone (chlorthalidone) might affect your kidneys, electrolyte levels, and cholesterol. These blood tests help your care team check that the medication is safe to keep taking.
- Thalitone (chlorthalidone) can make your skin more sensitive to sunlight. This can make sunburns more likely. Use sunscreen and wear protective clothing when you're outside, even if it's cloudy or winter.
More on Thalitone (chlorthalidone) tips
Risks and warnings for Thalitone (chlorthalidone)
Thalitone (chlorthalidone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Kidney problems
- Risk factors: History of kidney problems | Heart failure | Dehydration
Diuretics like Thalitone (chlorthalidone) can affect your kidney function. They make your body lose extra fluids, which can sometimes lead to kidney injury. The risk might be higher if you have kidney problems, heart failure, or dehydration.
You might need occasional blood tests done while taking Thalitone (chlorthalidone). This helps your prescriber check that your kidneys are okay during treatment. Tell your care team right away if you urinate less than usual, have swelling in your legs, or feel very weak or confused. These can be signs of kidney problems.
Abnormal electrolyte levels
Thalitone (chlorthalidone) works in your kidneys to help your body get rid of extra water and electrolytes. This can change the levels of electrolytes in your body. It can cause low sodium, potassium, magnesium, or chloride levels. It might also cause high calcium levels.
You might need regular blood tests while taking Thalitone (chlorthalidone) to check your electrolyte levels. If your levels are abnormal, your care team can help manage this problem.
Let your care team know if you feel very thirsty, tired, weak, or confused. Also tell them if you have muscle weakness, muscle twitching, nausea, vomiting, or a fast heartbeat. These can be signs of electrolyte problems, and you might need a blood test to check.
Higher blood sugar
- Risk factors: Diabetes
Thalitone (chlorthalidone) might raise your blood sugar levels. Be aware of the signs of high blood sugar, which can include dry mouth, feeling very thirsty, needing to urinate more often, and headaches. If you have these symptoms while taking this medication, let your care team know.
If you have diabetes, tell your prescriber. They might want you to check your blood sugar more often while taking Thalitone (chlorthalidone). Let your diabetes care team know if your blood sugar stays higher than usual. They might need to make changes to your treatment plan to control your blood sugar better.
Higher cholesterol and triglyceride levels
Thalitone (chlorthalidone) might raise your cholesterol levels. It might also raise the levels of a type of fat called triglycerides. You might need blood tests done periodically while taking this medication. This can help make sure your cholesterol levels stay in the normal range.
Risk of gout
- Risk factors: History of gout
Thalitone (chlorthalidone) can raise the uric acid levels in your body. This can cause or worsen gout in certain people. Tell your prescriber if you have a history of gout. Let your care team know if your joints swell, get red, or hurt while taking this medication.
Thalitone (chlorthalidone) dosage
The average cost for 30 tablets of 15mg of Thalitone (chlorthalidone) is $118.67 with a free GoodRx coupon. This is 12.02% off the average retail price of $134.89. 
Tablet
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 15mg | 30 tablets | $118.67 | $3.96 |
Typical dosage for Thalitone (chlorthalidone)
- High blood pressure: The typical starting dose is 15 mg by mouth once daily. After 2 weeks, your prescriber might raise your dose to 25 mg once daily if needed.
- Swelling from fluid buildup: The typical starting dose is 50 mg to 100 mg by mouth once daily. Another option is 100 mg by mouth every other day. If needed, your prescriber will adjust your dose. The maximum dose is 200 mg once daily.
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Interactions between Thalitone (chlorthalidone) and other drugs
Thalitone (chlorthalidone) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Thalitone (chlorthalidone). Please note that only the generic name of each medication is listed below.
More on Thalitone (chlorthalidone) interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aceclofenac
- Acemetacin
- Acetyldigoxin
- Amtolmetin Guacil
- Arsenic Trioxide
- Aspirin
- Bepridil
- Bromfenac
- Bufexamac
- Celecoxib
- Choline Salicylate
- Clonixin
- Deslanoside
- Desmopressin
- Dexibuprofen
- Dexketoprofen
- Diclofenac
- Diflunisal
- Digitalis
- Digitoxin
- Digoxin
- Dipyrone
- Dofetilide
- Droperidol
- Droxicam
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenoprofen
- Fepradinol
- Feprazone
- Flecainide
- Floctafenine
- Flufenamic Acid
- Flurbiprofen
- Ibuprofen
- Indomethacin
- Ketanserin
- Ketoprofen
- Ketorolac
- Levomethadyl
- Lithium
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Metildigoxin
- Morniflumate
- Nabumetone
- Naproxen
- Nepafenac
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Oxaprozin
- Oxyphenbutazone
- Parecoxib
- Phenylbutazone
- Piketoprofen
- Piroxicam
- Proglumetacin
- Propyphenazone
- Proquazone
- Rofecoxib
- Salicylic Acid
- Salsalate
- Sodium Salicylate
- Sotalol
- Sulindac
- Tenoxicam
- Tiaprofenic Acid
- Tolfenamic Acid
- Tolmetin
- Valdecoxib
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aminolevulinic Acid
- Gossypol
- Licorice
- Warfarin
How much does Thalitone (chlorthalidone) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Thalitone (brand)
$118.67
Thalitone (chlorthalidone) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Thalitone (chlorthalidone) will not be safe for you to take.
- Not making urine (not urinating)
- Allergy to "sulfa drugs"
What are alternatives to Thalitone (chlorthalidone)?
There are a number of medications that your doctor can prescribe in place of Thalitone (chlorthalidone). Compare a few possible alternatives below.
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