The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Please note: The side effects listed below includes those reported by people who took Rydapt (midostaurin) for AML and systemic mastocytosis.
- Nausea (up to 83%)
- Fever from low white blood cell counts (up to 83%)
- High blood sugar levels (up to 80%)
- Lower blood calcium levels (up to 74%)
- Vomiting (up to 68%)
- Redness, pain, or ulcers on the inside of the mouth (up to 66%)
- Abnormal blood cell counts (up to 66%)
- Diarrhea (54%)
- Headache (46%)
- Swelling in the hands and feet (40%)
- Abnormal liver labs (up to 39%)
- Higher pancreatic enzyme levels (up to 37%)
- Higher uric acid levels (up to 37%)
- Red/brown/purple spots on skin (36%)
Less Common Side Effects
- Stomach pain
- Stomach bleeding
- Constipation
- Hemorrhoids
- Joint stiffness
- Cough
- Trouble breathing
- Nosebleeds
- Rash
- Infections
- Sweating
- Tiredness
- Muscle or bone pain
- Trouble sleeping
Rydapt serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Lung problems: cough, trouble breathing, chest pain
Source: DailyMed
The following Rydapt side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
- Dry cough, shortness of breath or trouble breathing
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Unusual bruising or bleeding
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
- Bone, joint, or muscle pain
- Constipation
- Headache
- Nausea
- Pain, redness, or swelling with sores inside the mouth or throat
- Swelling of the ankles, hands, or feet
- Vomiting
