The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
The following side effects were reported in people taking the medication for kidney cancer. Side effects might differ for those with other types of cancers.
- Diarrhea (43%)
- Rash (40%)
- Fatigue (37%)
- Hand-foot skin reaction (30%)
- Hair loss (27%)
- Nausea (23%)
- High blood pressure (17%)
- Lower appetite (16%)
- Vomiting (16%)
- Bleeding (15%)
Less Common Side Effects
- Itching
- Dry skin
- Constipation
- Stomach pain
- Weight loss
- Tingling in hands and feet (peripheral neuropathy)
- Headache
- Joint pain
- Shortness of breath
Nexavar serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Heart problems: chest pounding, chest pain, irregular heartbeat, shortness of breath, feeling faint or lightheaded, swelling in the legs
- Serious bleeding: unusual bleeding, bleeding that’s difficult to stop, easy bruising, blood in urine or stool
- Serious skin reactions: skin rash, redness, blistering, pain, swelling
- Gut damage: fever, chills, intense stomach pain or cramps, bloating
- Serious liver problems: right-sided stomach pain, tiredness, loss of appetite, yellowing of the skin or eyes
Source: DailyMed
The following Nexavar side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Bleeding gums
blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
bloating of the abdomen or stomach
blood in the urine or stools
blurred vision
clay-colored stools
coughing up blood
dark urine
difficulty with breathing or swallowing
dizziness
headache
increased menstrual flow or vaginal bleeding
light-colored stools
nervousness
nosebleeds
paralysis
pounding in the ears
prolonged bleeding from cuts
red or black, tarry stools
red or dark brown urine
slow or fast heartbeat
stomach pain
tightness in the chest
vomiting
vomiting of blood
yellow eyes or skin
Less common
Bone pain
burning feeling in the chest or stomach
chest pain or discomfort
chills
clammy skin
confusion
decreased urine production
depressed mood
difficulty with moving
dry skin and hair
enlarged pupils (black part of the eye)
fainting
feeling cold
hearing loss
hoarseness or husky voice
increase in heart rate
increased sensitivity of the eyes to light
increased sweating, possibly with fever or cold
increased thirst
indigestion
joint pain or swelling
lightheadedness
loss of appetite
loss of the ability to use or understand speech or language
lower back or side pain
muscle cramps, pain, or stiffness
pain or discomfort in the arms, jaw, back, or neck
painful or difficult urination
pains in the stomach, side, or abdomen, possibly radiating to the back
pale skin
pinpoint red spots on the skin
rapid breathing
reddening of the skin, especially around the ears
ringing, buzzing, or other unexplained noise in the ears that continues
seizures
severe chest pain
severe headache
shivering
skin rash that is encrusted, scaly, and oozing
sores, ulcers, or white spots on the lips or in the mouth
stiff or sore neck
stomach discomfort or upset
sweating
swelling of the ankles or hands
swelling of the eyes, face, or inside of the nose
swollen glands
trouble breathing with exertion
unpleasant breath odor
unusual bleeding or bruising
unusual tiredness or weakness
Incidence not known
Blistering, peeling, or loosening of the skin
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
red skin lesions, often with a purple center
red, irritated eyes
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Burning, tingling, numbness or pain in the hands, arms, feet, or legs
numbness, pain, tingling, or unusual sensations in palms of the hands or bottom of the feet
sensation of pins and needles
stabbing pain
thinning of the hair
Less common
belching
burning, itching, and pain in hairy areas
cracked lips
cracks in the skin
decreased appetite
decreased interest in sexual intercourse
discouragement
feeling of warmth
feeling sad or empty
flushing or red skin
general feeling of discomfort or illness
inability to have or keep an erection
irritability
lack or loss of strength
loss in sexual ability, desire, drive, or performance
loss of heat from the body
loss of interest or pleasure
mouth pain
pus at the root of the hair
red face, neck, arms, and occasionally, upper chest
red, swollen skin
sunken eyes
swelling of the breasts or breast soreness in both men and women
swelling or inflammation of the mouth
tenderness in the stomach area
thirst
trouble concentrating
trouble sleeping
unusually warm skin
wrinkled skin
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
