The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Feeling tired (58%)
- Nausea (52%)
- Diarrhea (40%)
- Bone pain (38%)
- Headache (29%)
- Fever (28%)
- Low red blood cell count (25%)
- Rash (25%)
- Muscle pain (22%)
- Joint pain (21%)
- Back pain (20%)
Side effects and percentages are listed for Rolvedon (eflapegrastim) in people with cancer receiving bone marrow-suppressing chemotherapy. Therefore, it's not clear if the side effects are due to Rolvedon (eflapegrastim) or the chemotherapy medication.
Less Common Side Effects
- Poor appetite
- Swelling in the arms or legs
- Stomach pain
- Dizziness
- Trouble catching your breath
- Cough
- Pain
- Injection-site reactions
- Flushing (feeling warm all of a sudden)
Rolvedon serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Acute respiratory distress syndrome (ARDS) fast breathing, trouble catching your breath, crackling sound in the lungs when your breath, fever, feeling very tired, chest pain, feeling confused
- Ruptured spleen: pain in your left upper stomach or shoulder
- Serious allergic reaction: rash, trouble breathing, swelling of your tongue, lips, or throat
- Kidney damage: swelling of face or ankles, dark colored urine, blood in urine, urinating less
- Low platelet count: easy bruising, longer bleeding time, blood in urine or stools
Source: DailyMed
The following Rolvedon side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Capillary leak syndrome—stomach or muscle pain, unusual weakness or fatigue, feeling faint or lightheaded, decrease in the amount of urine, swelling of the ankles, hands, or feet, trouble breathing
- High white blood cell level—fever, fatigue, trouble breathing, night sweats, change in vision, weight loss
- Inflammation of the aorta—fever, fatigue, back, chest, or stomach pain, severe headache
- Kidney injury (glomerulonephritis)—decrease in the amount of urine, red or dark brown urine, foamy or bubbly urine, swelling of the ankles, hands, or feet
- Shortness of breath or trouble breathing
- Spleen injury—pain in upper left stomach or shoulder
- Unusual bruising or bleeding
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Bone pain
- Diarrhea
- Fatigue
- Headache
- Muscle pain
- Nausea
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