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Ryzneuta

Ryzneuta Side Effects

Ally Tsai, PharmDKristianne Hannemann, PharmD
Reviewed by Ally Tsai, PharmD, Kristianne Hannemann, PharmD
Last reviewed on January 5, 2026

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (51%)
  • Low red blood cell count (15%)
  • Low platelet count (12%)

Less Common Side Effects

  • Tiredness
  • Bone pain

Ryzneuta serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Spleen rupture: pain in the left upper stomach, pain in the left shoulder
  • Breathing problems: shortness of breath, fever, trouble breathing, breathing fast
  • Serious allergic reaction: rash, shortness of breath, facial or throat swelling, dizziness, fast heart rate
  • Kidney injury: swelling of the face or ankles, dark-colored urine, blood in the urine, urinating less than usual
  • Capillary leak syndrome (CLS): swelling or puffy, urinating less than normal, trouble breathing, swelling in the stomach and feeling full, dizziness, feeling faint, tiredness
  • Blood problem: tiredness, fever, easy bruising or bleeding
  • Inflammation of the aorta: fever, stomach pain, tiredness, back pain

Source: DailyMed

The following Ryzneuta side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Capillary leak syndrome—stomach or muscle pain, unusual weakness or fatigue, feeling faint or lightheaded, decrease in the amount of urine, swelling of the ankles, hands, or feet, trouble breathing
  • High white blood cell level—fever, fatigue, trouble breathing, night sweats, change in vision, weight loss
  • Inflammation of the aorta—fever, fatigue, back, chest, or stomach pain, severe headache
  • Kidney injury (glomerulonephritis)—decrease in the amount of urine, red or dark brown urine, foamy or bubbly urine, swelling of the ankles, hands, or feet
  • Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
  • Shortness of breath or trouble breathing
  • Spleen injury—pain in upper left stomach or shoulder
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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