The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Bone pain (3%)
Less Common Side Effects
- Muscle pain
- Headache
- Vomiting
- Rash
Granix serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Ruptured spleen: pain in your left upper stomach or shoulder
- Serious lung problem: shortness of breath, fast rate of breathing or trouble breathing
- Serious allergic reaction: rash, face swelling, shortness of breath, fast heart rate
- Kidney damage: swelling of face or ankles, dark colored urine, blood in urine, urinating less
Source: DailyMed
The following Granix side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Capillary leak syndrome—stomach or muscle pain, unusual weakness or fatigue, feeling faint or lightheaded, decrease in the amount of urine, swelling of the ankles, hands, or feet, trouble breathing
- High white blood cell level—fever, fatigue, trouble breathing, night sweats, change in vision, weight loss
- Inflammation of the aorta—fever, fatigue, back, chest, or stomach pain, severe headache
- Kidney injury (glomerulonephritis)—decrease in the amount of urine, red or dark brown urine, foamy or bubbly urine, swelling of the ankles, hands, or feet
- Shortness of breath or trouble breathing
- Spleen injury—pain in upper left stomach or shoulder
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
- Bone pain
- Diarrhea
- Fever
- Headache
- Muscle pain
- Vomiting

