The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Fever (95%)
- Nausea (90%)
- Diarrhea (89%)
- Vomiting (85%)
- Blisters or sores in sensitive skin areas (75%)
- Hair loss (73%)
- Weakness or lack of energy (up to 66%)
- Low appetite or stomach-related problems (up to 54%)
- Rash (44%)
- Swelling (34%)
- Stomach bleeds (27%)
Less Common Side Effects
- Mouth sores
- Trouble breathing
- Bleeds
- Urinary tract infections
Please note: These side effects were reported in clinical trials by people who received Leukine (sargramostim) after bone marrow transplant. The side effects you experience might be different if you're being treated for a different condition.
Leukine serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Infusion-related reactions: trouble breathing, flushing, dizziness, fainting, fast heartbeat
- Serious allergic reaction: rash, swelling around your mouth or eyes, trouble breathing, wheezing
- Too much body fluid: sudden weight gain, welling in feet or ankles, trouble breathing, dizziness, feeling tired
- Abnormal heart rhythm
Source: DailyMed
The following Leukine side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Black, tarry stools
bloating or swelling of the face, arms, hands, lower legs, or feet
blood in the eye
bloody nose
blurred vision
body aches or pain
bone pain
cloudy urine
congestion
decrease in urine output or decrease in urine-concentrating ability
difficult or labored breathing
drowsiness
dryness or soreness of the throat
fast, pounding, or irregular heartbeat or pulse
flushed, dry skin
fruit-like breath odor
hoarseness
increased hunger
increased thirst
increased urination
irregular heartbeat
large amount of cholesterol in the blood
loss of appetite
mood or mental changes
rapid weight gain
redness in whites of eyes
stomach pain
sweating
tender, swollen glands in the neck
tightness in the chest
tingling of the hands or feet
trouble with swallowing
trembling
twitching
unusual tiredness or weakness
unusual weight gain or loss
voice changes
vomiting
vomiting of blood or material that looks like coffee grounds
yellow eyes or skin
Incidence not known
Chills
confusion
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
general feeling of illness
headache
pain in the chest, groin, or legs, especially the calves
severe, sudden headache
slurred speech
sudden loss of coordination
sudden, severe weakness or numbness in the arm or leg
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
difficulty in moving
fear or nervousness
itching skin
lack or loss of strength
muscle pain or stiffness
pain in the joints
trouble sleeping
Incidence not known
Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
feeling of warmth
redness of the face, neck, arms, and occasionally, upper chest
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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