Rolvedon

Some people have experienced enlarged spleens after receiving colony-stimulating factor medications like Rolvedon (eflapegrastim). This has sometimes led to death because of damage or burst in the spleen. Contact your provider if you notice any pain in the upper left stomach area or in your shoulder.

Rolvedon (eflapegrastim) can cause a serious breathing condition called acute respiratory distress syndrome (ARDS). It causes fluid to leak in your lungs, which prevents enough oxygen from getting into your blood and to your organs. If you experience ARDS, your provider will ask you to stop Rolvedon (eflapegrastim). Get medical help right away if you have shortness of breath, fever, or fast breathing.

Rolvedon (eflapegrastim) can cause serious allergic reactions, which can be life threatening. Don't take Rolvedon (eflapegrastim) if you've ever had an allergic reaction to it or a similar medication, like Neupogen (filgrastim). If you experience rash, trouble breathing, or swelling of your lips, tongue, or throat, get medical attention right away.

Sickle cell crisis (painful episode) can happen in people with sickle cell anemia while receiving Rolvedon (eflapegrastim). In more severe cases, it could be deadly. If this happens, your healthcare provider will stop the medication.

Some people taking medications similar to Rolvedon (eflapegrastim) have experienced kidney injury, such as inflammation of the kidneys. If your provider suspects that you have kidney problems, you might need to get blood work done so they can check your kidney health. Then, they can decide if they need to lower your dose of or pause Rolvedon (eflapegrastim). If you have kidney problems from the medication, your condition will usually get better once your provider lower the dose. Let your provider know if you notice red or dark brown urine, or that you're not urinating as much.

Colony-stimulating factor medications like Rolvedon (eflapegrastim) can cause capillary leak syndrome (CLS). CLS is a serious condition where fluid leaks out of your small blood vessels. A common sign of this is low blood pressure, but certain lab results can also suggest CLS. Talk to your provider if you notice low blood pressure (e.g., dizziness, fainting), tiredness, stomach pain, extreme thirst, or sudden weight gain. Your provider will need to examine you further and provide treatment if needed.

Rolvedon (eflapegrastim) is a growth factor that primarily triggers the production of white blood cells in the body. But there's also a possibility for it to promote the growth of other types of tumors. Some people reported developing blood-related cancers and bone marrow problems when they used Rolvedon (eflapegrastim) as part of their treatment plan for breast or lung cancer along with chemotherapy or radiation. Your providers will check your labs closely and might stop Rolvedon (eflapegrastim) if the the benefits no longer outweigh the risks.

Rolvedon (eflapegrastim) has been linked to a condition caused by inflammation of blood vessels called aortitis. This condition could happen as early as the first week after starting treatment. Let your provider know if you experience fever, stomach pain, back pain, or feel unwell so you can be checked out.