Rezvoglar
Rezvoglar KwikPen is the brand name for insulin glargine (or insulin glargine-aglr). It's a long-acting insulin pen for adults and children with diabetes. This medication is an FDA-approved insulin biosimlar; it's highly similar to Lantus (insulin glargine). Rezvoglar (insulin glargine) is injected under the skin once a day. But it might cause side effects such as low blood sugar and reactions at the injection site.
What is Rezvoglar (insulin glargine)?
What is Rezvoglar (insulin glargine) used for?
Type 1 diabetes (T1D)
Type 2 diabetes (T2D)
How Rezvoglar (insulin glargine) works
Rezvoglar (insulin glargine) is a long-acting insulin. Insulin is a hormone in your body that lowers glucose (sugar) levels in the blood in a few ways. It helps your body use sugar from your blood for energy. It also stops your liver from making glucose.
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What are the side effects of Rezvoglar (insulin glargine)?
Common Side Effects
- Upper respiratory tract infection (14%)
- Other infection (14%)
- Sore throat (8%)
- Runny nose (5%)
- Upper respiratory tract infection (22%)
- Other infection (9%)
- Accidental injury (6%)
- Headache (6%)
- Upper respiratory tract infection (29%)
- Swelling in arm or leg (20%)
- High blood pressure (20%)
- Flu-like symptoms (19%)
- Sinus infection (19%)
- Cataract (18%)
- Bronchitis (15%)
Other Side Effects
- Low blood sugar
- Pain in back, arms, legs, hands, or feet
- Cough
- Diarrhea
- Urinary tract infection
- Depression
- Injection site reaction (e.g., redness, pain, itching, swelling)
- Weight gain
Serious Side Effects
- Dangerously low blood sugar: feeling shaky, being nervous or anxious, fast heartbeat, sweating, body chills, confusion, feeling sleepy, weakness, low energy, feeling very hungry
- Low potassium levels: weakness, muscle cramps or twitches, tiredness, abnormal heartbeat
- Severe allergic reaction: rash; fast heartbeat; breathing problems; swelling in your face, mouth, or throat
Source: DailyMed
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The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Low blood sugar (hypoglycemia)—tremors or shaking, anxiety, sweating, cold or clammy skin, confusion, dizziness, rapid heartbeat
- Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Lipodystrophy—hardening or scarring of tissue at injection site
- Pain, redness, or irritation at injection site
- Weight gain
Pros and cons of Rezvoglar (insulin glargine)
Pros
A long-lasting insulin that's used once daily for stable, all-day blood sugar control
Comes as an injectable pen that's small enough to fit in your purse or pocket
Easily adjustable doses to make a customized regimen tailored to your needs
One of the most effective medications for controlling blood sugar
Cons
Must inject the medication under the skin
Must get needles for the pen separately
Can cause weight gain like other insulins
Can cause low blood sugar, especially if you don't take the medication consistently or have an inconsistent meal and exercise schedule
Pharmacist tips for Rezvoglar (insulin glargine)
Read the detailed Instructions for Use that come with Rezvoglar (insulin glargine) before you first use it. It's important to make sure you understand how to use the medication safely. Also review tips on starting insulin. Ask a healthcare professional if you have any questions.
A common side effect of Rezvoglar (insulin glargine) is low blood sugar. Make sure you and your loved ones know how to recognize and treat low blood sugar. Some symptoms of low blood sugar include being very hungry, shaky, sweaty, nervous, anxious, dizzy, or confused. Have some fast-acting sugars with you to help get your blood sugar back up.
Don't dilute or mix Rezvoglar (insulin glargine) with other types of insulin. It's not known if it's safe or how it might affect your blood sugar levels. You also can't use Rezvoglar (insulin glargine) in an insulin pump.
You might get prescribed other types of insulins to use at different times of the day, depending on your blood sugar control. Always check your insulin labels carefully so you know you're using the right insulin at the right time. Double checking helps prevent you from mixing up between your insulins and possible low blood sugar.
Follow a consistent meal plan and keep your exercise routine relatively the same. Don't make changes that are too drastic or sudden. This helps keep your blood sugar steady while taking Rezvoglar (insulin glargine).
Store unopened Rezvoglar (insulin glargine) pens in the refrigerator until the expiration date. You can also keep unopened pens at room temperature for up to 28 days. Once you start using a pen, store the opened pen at room temperature for up to 28 days. Don't put opened pens in the refrigerator.
When you take out a new Rezvoglar (insulin glargine) pen from the refrigerator, let it reach room temperature for at least 1 hour before you inject the medication. Injecting it cold might be more painful.
Always use a new needle for each injection. Don't reuse needles because this raises your risk of infections. It can also block your needle, which can cause you to inject the wrong dose of insulin.
Remember to "prime" the Rezvoglar (insulin glargine) pen before each injection. Follow the instructions to check that the pen and needle are working as they should and to prepare the pen.
Inject Rezvoglar (insulin glargine) at the same time each day. Inject it under the skin into the fatty tissue of your stomach, thigh (upper leg), or upper arm. Use a different spot each time to prevent skin irritation or damage. Never inject the medication into a vein or muscle. This can cause very low blood sugar levels and infections.
Don't repeatedly inject Rezvoglar (insulin glargine) into areas of skin with signs of lipodystrophy (pitted or thickened skin). Injecting into these areas too often can affect how well the insulin gets absorbed into the body. This can raise your risk of having higher blood sugar levels.
Throw away used needles in a sharps container, hard plastic container, or metal container. Never throw needles away in the trash to avoid needle-stick injuries. For more information on safe disposal, visit the FDA's website.
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Frequently asked questions about Rezvoglar (insulin glargine)
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What are the risks and warnings for Rezvoglar (insulin glargine)?
Rezvoglar (insulin glargine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk of infections from sharing pens and needles
Never share your Rezvoglar (insulin glargine) pen or needles with anyone else. Even if you put on a new needle, don't let others use your pen. Sharing Rezvoglar (insulin glargine) and your injection supplies can raise the risk of spreading serious infections.
Risk of changes to blood sugar levels with changes to your insulin regimen
Risk factors: Changes in insulin strength | Changes in type of insulins you use | Changes in insulin brand-name products | Suddenly changing where you inject
Changing your insulin or how you use it can affect how your body responds to insulin. Examples include suddenly changing where you inject Rezvoglar (insulin glargine) or switching to a different type of insulin. This can lead to higher or lower blood sugar levels.
If your diabetes care team tells you to make any changes, be sure to check your blood sugar more often. This helps you know how the changes affect you. Don't change your Rezvoglar (insulin glargine) dose or routine without talking to your diabetes team first.
Low blood sugar (hypoglycemia)
Risk factors: Changes in meal patterns and exercise routines | Drinking alcohol | Taking other medications for diabetes | Liver or kidney problems
Rezvoglar (insulin glargine) can cause low blood sugar, which is also called hypoglycemia. Sometimes, your blood sugar can get too low. This can be dangerous and even life-threatening if not treated in time. Make sure to follow your prescriber's instructions and check your blood sugar regularly.
Be sure you can spot signs of low blood sugar so you can catch it early. You might feel shaky, dizzy, sweaty, clammy, nervous, irritated, or confused. You could also have trouble focusing or reacting quickly, which can be risky during activities like driving. Keep in mind that low blood sugar can happen suddenly and look different for each person.
It's important to know how to treat low blood sugar. Always carry some fast-acting sugars with you while you're taking Rezvoglar (insulin glargine). Some examples include 3 or 4 glucose (sugar) tablets or one-half cup of fruit juice. These can help raise your blood sugar quickly. If you have low blood sugar, treat it right away and let your diabetes team know.
Severe allergic reaction
Risk factors: History of allergic reaction to insulin
Rarely, Rezvoglar (insulin glargine) can cause severe allergic reactions that can be life-threatening. Go to the emergency room right away if you suddenly have trouble breathing or if your face, mouth, or throat starts to swell.
Low potassium levels
Risk factors: Taking other medications that lower your potassium
Rezvoglar (insulin glargine) can lower your potassium levels, which can sometimes be dangerous. You're at greater risk if you take other medications that lower your potassium, like diuretics (water pills). If needed, your prescriber might check your potassium levels regularly.
Watch for symptoms of low potassium. They can include weakness, tiredness, muscle cramps, constipation, and abnormal heartbeat. Tell your care team if you have any of these symptoms so they can help treat and manage this problem.
Swelling and risk of heart failure when using with certain diabetes medications
Risk factors: Taking glitazones together with insulin | History of heart failure
Taking Rezvoglar (insulin glargine) with diabetes medications called glitazones, such as pioglitazone (Actos), can cause your body to hold onto extra fluid. It can lead to or worsen heart failure. This is because the extra fluid can put stress on the heart.
Before you start Rezvoglar (insulin glargine), tell your prescriber if you have heart failure or if you take other diabetes medications. They can make sure to follow up with you more closely. Let your care team know if you have swelling in your legs or ankles, feel very tired, or have trouble breathing. These could be signs of fluid buildup or heart failure.
Rezvoglar (insulin glargine) dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 5 prefilled 3ml pens of 100 units/ml | 1 carton | $97.93 | $97.93 |
Typical dosing for Rezvoglar (insulin glargine)
Rezvoglar (insulin glargine) is injected under the skin once a day. Inject into the fatty tissue of your stomach, thigh (upper leg), or upper arm.
Type 1 diabetes: The recommended starting dose is about one-third of your total daily insulin requirements. Your prescriber will help you find the right dose, so follow their instructions carefully. Use Rezvoglar (insulin glargine) along with a short-acting or rapid-acting insulin that's used before meals. This helps make sure your body gets all the insulin it needs each day.
Type 2 diabetes: The recommended starting dose is 0.2 units/kg of body weight (or up to 10 units) each day.
Your prescriber will help you find the right dose, so follow their instructions carefully. Your starting dose might be different if you're switching from another insulin product. Your dose might get adjusted later depending on how well your blood sugar stays controlled.
How much does Rezvoglar (insulin glargine) cost?
Rezvoglar (insulin glargine) contraindications
When you have low blood sugar levels
Allergy to Rezvoglar (insulin glargine) or other insulin glargine products
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