Proton pump inhibitors are used to treat GERD, gastric ulcers, duodenal ulcers, and heartburn. They work by healing the esophagus and by decreasing the amount of stomach acid.

Why are
Proton Pump Inhibitors
prescribed?

How is this chart calculated?

How we make this chart

This chart is created by aggregating the total number of claims for the drugs in this class divided by the # of drugs with a specific indication. It is meant to be representative but may not accurately reflect the actual # of prescriptions written to treat a specific condition.

Prices for Popular Proton Pump Inhibitors

Popularity Brand Name (Generic Name) GoodRx Fair Price Price Trend
Prilosec
(omeprazole)
9
See Prices
Omeprazole (Prilosec) is an inexpensive drug used to treat certain conditions where there is too much acid in the stomach like ulcers and gastroesophageal reflux disease (GERD). It is more popular than comparable drugs. It is available in both generic and brand versions, and without a prescription. Generic omeprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Protonix
(pantoprazole)
10
See Prices
Pantoprazole (Protonix) is an inexpensive drug used to treat gastroesophageal reflux disease, inflammation of the esophagus, and Zollinger-Ellison syndrome. This drug is slightly more popular than comparable drugs. It is available in brand and generic form. Generic pantoprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Prevacid
(lansoprazole)
15
See Prices
Prevacid (lansoprazole) is a proton pump inhibitor (PPI) used to treat GERD, heartburn, gastric ulcer, and duodenal ulcer. It works by reducing acid in the stomach. It is also approved for use in combination with antibiotics for the treatment of Helicobacter pylori (H. pylori) infection. It is available by prescription and over the counter as Prevacid 24HR. Generic lansoprazole is also available both by prescription and over the counter.
Nexium
(esomeprazole)
89
See Prices
Esomeprazole (Nexium) is an expensive drug used to treat gastroesophageal reflux disease (GERD), ulcers, certain bacteria in the stomach, and inflammation of the esophagus. It can also be used to prevent ulcers in patients taking medicines called NSAIDs. This drug is more popular than comparable drugs. It is available in brand and generic form. Generic esomeprazole is covered by some Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Dexilant
252
See Prices
Dexlansoprazole (Dexilant) is an expensive drug used to treat gastroesophageal reflux disease (GERD) and inflammation of the esophagus. This drug is less popular than comparable drugs. A generic form of Dexilant may become available in 2020. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Aciphex
(rabeprazole dr)
23
See Prices
RABEPRAZOLE prevents the production of acid in the stomach. It is used to treat gastroesophageal reflux disease (GERD), certain ulcers, inflammation of the esophagus, and Zollinger-Ellison Syndrome.
Prilosec Otc
(omeprazole otc)
N/A N/A See Prices
Prilosec OTC is the over the counter version of prescription Prilosec (omeprazole). It is a proton pump inhibitor (PPI) used to treat frequent heartburn by reducing the acid in the stomach. Generic omeprazole is also available without a prescription.
Nexium 24Hr
N/A N/A See Prices
ESOMEPRAZOLE prevents the production of acid in the stomach. It is used to treat gastroesophageal reflux disease (GERD), ulcers, certain bacteria in the stomach, and inflammation of the esophagus. It can also be used to prevent ulcers in patients taking medicines called NSAIDs.
Zegerid
(omeprazole/sodium bicarbonate)
327
See Prices
Omeprazole/sodium bicarbonate (Zegerid) is an expensive drug used to treat gastric and duodenal ulcers, erosive esophagitis, and gastroesophageal reflux disease (GERD). This drug is slightly less popular than comparable drugs. It is available in brand and generic versions. It is not covered by most Medicare and insurance plans, but some manufacturer and pharmacy coupons can help offset the cost.
Prevacid 24Hr
N/A N/A See Prices
Prevacid 24HR is the over-the-counter version of prescription Prevacid (lansoprazole), though the two are not considered equivalent. It is a proton pump inhibitor (PPI) used to treat frequent heartburn by reducing the acid in the stomach. Generic lansoprazole is also available over the counter.
pink bismuth
N/A N/A See Prices
BISMUTH SUBSALICYLATE relieves the symptoms of diarrhea, upset stomach, heartburn, acid indigestion, and nausea.
Lansoprazole 24Hr
N/A N/A See Prices
Lansoprazole is available both over-the-counter and by prescription, though the two versions are not considered equivalent. It is a proton pump inhibitor (PPI) used to treat frequent heartburn by reducing the acid in the stomach. Brand name lansoprazole sold over the counter is known as Prevacid 24HR.
Zegerid Otc
(omeprazole/sodium bicarbonate otc)
N/A N/A See Prices
Zegerid OTC is the over-the-counter version of prescription Zegerid (omeprazole/sodium bicarbonate), though the two are not considered equivalent. It is a proton pump inhibitor (PPI) used to treat frequent heartburn by reducing the acid in the stomach. There is currently no generic version available over the counter.
Esomeprazole Strontium
69
See Prices

Note: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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