methscopolamine
Methscopolamine is an anticholinergic medication that's used to treat peptic ulcers in adults. Although its brand name Pamine is no longer available, the generic methscopolamine tablets can be prescribed. This medication is taken by mouth before meals and at bedtime. Side effects can include dry mouth, blurry vision, and sleepiness.
What is Methscopolamine?
What is Methscopolamine used for?
- Peptic ulcers (as add-on therapy)
How Methscopolamine works
Methscopolamine is an anticholinergic medication. It works by blocking a chemical called acetylcholine from attaching to its receptors in your stomach and intestines. This helps lower the amount of acid in the stomach and slow movement in the gut. These actions help with pain and discomfort from stomach ulcers (peptic ulcers).
Drug facts
| Common Brands | Pamine |
|---|---|
| Drug Class | Anticholinergic |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
Side effects of Methscopolamine
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Dry mouth
- Constipation
- Nausea
- Vomiting
Less Common Side Effects
- Headache
- Nervousness
- Confusion
- Sleepiness
- Dizziness
- Weakness
- Blurry vision
- Loss of taste
- Difficulty urinating
- Bloating
- Less sweating
- Difficulty sleeping
- Fast heart rate
The following Methscopolamine side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Confusion (especially in the elderly)
dizziness, lightheadedness that continues, or fainting
skin rash or hives
Incidence not known
difficulty with swallowing
fast irregular, pounding, or racing heartbeat or pulse
hives or welts
hoarseness
irritation
itching skin
joint pain, stiffness, or swelling
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
redness of the skin
shortness of breath
skin rash
tightness in the chest
trouble with breathing
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common or rare
Bloated feeling
blurred vision
difficult urination
difficulty with swallowing
drowsiness
false sense of well-being
headache
increased sensitivity of eyes to light
loss of memory
nausea or vomiting
redness or other signs of irritation at the place of injection
trouble with sleeping
unusual tiredness or weakness
Incidence not known
Decreased interest in sexual intercourse
inability to have or keep an erection
loss in sexual ability, desire, drive, or performance
loss of taste
For patients using scopolamine:
After you stop using scopolamine, your body may need time to adjust. The length of time this takes depends on the amount of scopolamine you were using and how long you used it. During this period of time check with your doctor if you notice any of the following side effects:
irritability
nightmares
pupil of one eye is larger (patch only)
sensitivity of eyes to light (patch only)
trouble in sleeping
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pros and cons of Methscopolamine
Pros
- Helps with pain and cramping due to stomach ulcers
- Available as tablets taken by mouth
Cons
- Not a common choice because it doesn't heal or prevent stomach ulcers
- Taken 4 times a day
Pharmacist tips for Methscopolamine
- Take methscopolamine on an empty stomach 30 minutes before each meal and at bedtime.
- Methscopolamine can cause sleepiness, dizziness, and blurry vision. These side effects can affect your ability to think, focus, and react. Don't drive, operate machinery, or do anything that requires concentration until you know how this medication affects you.
- Dry mouth is a possible side effect of methscopolamine because the medication can cause your body to make less saliva. Make sure to drink plenty of water while you're taking this medication to help relieve dry mouth.
- It's also important to stay hydrated while you're taking methscopolamine because the medication can make it easier for you to overheat in hot temperatures. Methscopolamine can cause your body to make less sweat, which can affect how well your body can cool down.
- Avoid alcohol while you're taking methscopolamine. It can make methscopolamine side effects like sleepiness worse, putting you at risk for falls or other accidents.
- Don't take methscopolamine with other anticholinergics, like diphenhydramine (Benadryl) or glycopyrrolate (Robinul). These medications work similarly to methscopolamine, and they have similar side effects. Taking anticholinergic medications with methscopolamine can make side effects, like dry mouth, headache, and dizziness, worse. It can also lead to more serious side effects, like overheating, confusion, and agitation.
- Talk to your care team if you want to take antacids for your stomach symptoms along with methscopolamine. Taking antacids at the same time as this medication can lower the amount of methscopolamine that's absorbed into the body, which can make it not work as well. Your care team can help you come up with a schedule to get the best results from both types of medications.
Risks and warnings for Methscopolamine
Methscopolamine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Changes to certain bodily functions
- Risk factors: Age 65 years or older
Methscopolamine can cause changes to your autonomic nervous system, which controls the functions of your body that you don't have to think about. For example, methscopolamine can cause the muscles of your gut to slow down, which can lead to constipation. This medication can also make you have less saliva in the mouth, leading to dry mouth. Methscopolamine can also affect other functions, such as your heartbeat or vision. Let your healthcare team know if you experience any unusual and bothersome changes to your bodily functions while you're taking this medication.
Risk for heat exhaustion or heatstroke
- Risk factors: Hot weather | In a warm environment
Methscopolamine can make you sweat less, which affects how well your body can cool itself down. This can put you at risk for fever, heat exhaustion, and heatstroke, especially when you're in a very warm environment. Don't take methscopolamine without asking your HCP first if you have a fever because the medication might make it worse.
Some early symptoms of heat exhaustion or heatstroke can include feeling thirstier, urinating less, having dry mouth, or feeling tired. But get medical help as soon as possible if these symptoms become severe or if you have additional symptoms like muscle cramping; faster or weaker pulse; confusion; hot, dry, red skin; or a very high fever.
Not appropriate for people with an intestinal (gut) blockage
- Risk factors: Ileostomy or colostomy | Ulcerative colitis | Taking high doses of methscopolamine
Let your prescriber know if you have any diarrhea. Sometimes, diarrhea is an early sign that you have a blockage in your gut, especially if you've had an ileostomy or colostomy (or any similar procedures) done. Taking methscopolamine in these situations can be harmful.
In addition, don't take methscopolamine if you have severe ulcerative colitis. Taking large doses of methscopolamine can slow the gut down to a stop. This can lead to serious problems, like severe inflammation and swelling of the colon.
Muscle weakness
- Risk factors: Taking too much methscopolamine
Make sure to take methscopolamine exactly as prescribed. Don't change your dose without talking to your prescriber. Taking too much methscopolamine can cause muscle weakness and paralysis. Stop taking methscopolamine and contact your prescriber right away if you notice muscle weakness or numbness in your body.
Methscopolamine dosage
Interactions between Methscopolamine and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.
- Ambenonium
- Bepridil
- Bromopride
- Cisapride
- Dronedarone
- Fluconazole
- Itraconazole
- Ketoconazole
- Mesoridazine
- Nelfinavir
- Pimozide
- Piperaquine
- Posaconazole
- Potassium
- Potassium Chloride
- Saquinavir
- Sparfloxacin
- Terfenadine
- Thioridazine
- Ziprasidone
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aclidinium
- Alfentanil
- Alfuzosin
- Alprazolam
- Amifampridine
- Amiodarone
- Amisulpride
- Amitriptyline
- Amobarbital
- Amoxapine
- Anagrelide
- Anileridine
- Apomorphine
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Asenapine
- Astemizole
- Atropine
- Azithromycin
- Baclofen
- Bedaquiline
- Belladonna
- Benzhydrocodone
- Benztropine
- Biperiden
- Bromazepam
- Brompheniramine
- Buprenorphine
- Bupropion
- Buserelin
- Buspirone
- Butabarbital
- Butorphanol
- Calcium Oxybate
- Cannabidiol
- Carbinoxamine
- Carisoprodol
- Ceritinib
- Cetirizine
- Chloral Hydrate
- Chlordiazepoxide
- Chloroquine
- Chlorpheniramine
- Chlorpromazine
- Chlorzoxazone
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clemastine
- Clidinium
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Codeine
- Conivaptan
- Crizotinib
- Cyclobenzaprine
- Cyclopentolate
- Cyclosporine
- Cyproheptadine
- Dabrafenib
- Darifenacin
- Darolutamide
- Dasatinib
- Degarelix
- Delamanid
- Desipramine
- Deslorelin
- Deutetrabenazine
- Dexmedetomidine
- Diacetylmorphine
- Diazepam
- Dicyclomine
- Difenoxin
- Digoxin
- Dihydrocodeine
- Dimenhydrinate
- Diphenhydramine
- Diphenoxylate
- Disopyramide
- Dofetilide
- Dolasetron
- Domperidone
- Donepezil
- Doxepin
- Doxylamine
- Droperidol
- Duvelisib
- Ebastine
- Efavirenz
- Eltrombopag
- Enasidenib
- Encorafenib
- Entrectinib
- Eribulin
- Erythromycin
- Escitalopram
- Esketamine
- Estazolam
- Eszopiclone
- Ethchlorvynol
- Ethylmorphine
- Famotidine
- Felbamate
- Fentanyl
- Fesoterodine
- Fingolimod
- Flavoxate
- Flecainide
- Flibanserin
- Fluconazole
- Flunitrazepam
- Fluoxetine
- Fluphenazine
- Flurazepam
- Formoterol
- Foscarnet
- Fosnetupitant
- Fosphenytoin
- Fospropofol
- Fostemsavir
- Gabapentin
- Gabapentin Enacarbil
- Galantamine
- Gatifloxacin
- Gemfibrozil
- Gemifloxacin
- Givosiran
- Glasdegib
- Glucagon
- Glycopyrrolate
- Glycopyrronium Tosylate
- Gonadorelin
- Goserelin
- Granisetron
- Halazepam
- Halofantrine
- Haloperidol
- Histrelin
- Homatropine
- Hydrocodone
- Hydromorphone
- Hydroquinidine
- Hydroxychloroquine
- Hydroxyzine
- Hyoscyamine
- Ibutilide
- Idelalisib
- Iloperidone
- Imipramine
- Inotuzumab Ozogamicin
- Ipratropium
- Itraconazole
- Ivabradine
- Ivosidenib
- Ketamine
- Ketazolam
- Ketobemidone
- Ketoconazole
- Lapatinib
- Larotrectinib
- Lefamulin
- Leflunomide
- Lemborexant
- Lenvatinib
- Levocetirizine
- Levofloxacin
- Levorphanol
- Lofexidine
- Lopinavir
- Lorazepam
- Lorlatinib
- Loxapine
- Lumacaftor
- Lumefantrine
- Macimorelin
- Magnesium Oxybate
- Meclizine
- Mefloquine
- Memantine
- Mepenzolate
- Meperidine
- Mephobarbital
- Meprobamate
- Meptazinol
- Metaxalone
- Methacholine
- Methadone
- Methocarbamol
- Methohexital
- Methotrimeprazine
- Metoclopramide
- Metronidazole
- Midazolam
- Mifepristone
- Mirtazapine
- Mizolastine
- Moricizine
- Morphine
- Morphine Sulfate Liposome
- Moxifloxacin
- Nafarelin
- Nalbuphine
- Netupitant
- Nicomorphine
- Nilotinib
- Nitrazepam
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Ondansetron
- Opium
- Opium Alkaloids
- Orphenadrine
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxazepam
- Oxitropium Bromide
- Oxybutynin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paliperidone
- Panobinostat
- Papaveretum
- Papaverine
- Paregoric
- Paroxetine
- Pasireotide
- Pazopanib
- Pentamidine
- Pentazocine
- Pentobarbital
- Perampanel
- Perphenazine
- Phenobarbital
- Pimavanserin
- Pimozide
- Pipamperone
- Pipenzolate Bromide
- Pirenzepine
- Piritramide
- Pitolisant
- Ponesimod
- Posaconazole
- Potassium Oxybate
- Prazepam
- Pregabalin
- Primidone
- Probucol
- Procainamide
- Prochlorperazine
- Procyclidine
- Promethazine
- Propafenone
- Propantheline
- Propiverine
- Propofol
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Remifentanil
- Remimazolam
- Revefenacin
- Ribociclib
- Rifampin
- Risperidone
- Scopolamine
- Secobarbital
- Secretin Human
- Selpercatinib
- Sertindole
- Sertraline
- Sevoflurane
- Siponimod
- Sodium Oxybate
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Solifenacin
- Sorafenib
- Sotalol
- Stramonium
- Sufentanil
- Sulpiride
- Sultopride
- Sunitinib
- Tacrolimus
- Tamoxifen
- Tapentadol
- Telavancin
- Temazepam
- Teriflunomide
- Terodiline
- Tetrabenazine
- Thiopental
- Thioridazine
- Thiothixene
- Tilidine
- Tiotropium
- Tizanidine
- Tolterodine
- Topiramate
- Toremifene
- Tramadol
- Trazodone
- Triazolam
- Triclabendazole
- Trifluoperazine
- Trihexyphenidyl
- Trimipramine
- Triptorelin
- Tropicamide
- Trospium
- Umeclidinium
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Vilanterol
- Vinflunine
- Voclosporin
- Voriconazole
- Vorinostat
- Zaleplon
- Zolpidem
- Zopiclone
- Zotepine
- Zuclopenthixol
How much does Methscopolamine cost?
$32.26
Methscopolamine contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Methscopolamine will not be safe for you to take.
- Glaucoma
- Blockage in the urinary tract (i.e., due to an enlarged prostate)
- Blockage in the stomach or intestines
- Severe ulcerative colitis
- Myasthenia gravis
- Unstable clinical status if you're bleeding