Skip to main content
Chlordiazepoxide/Amitriptyline Coupon - Chlordiazepoxide/Amitriptyline 5mg/12.5mg tablet

chlordiazepoxide / amitriptyline

Generic Limbitrol
Used for Anxiety, Depression

Chlordiazepoxide/amitriptyline is a combination medication containing chlordiazepoxide and amitriptyline. It treats depression related to anxiety, but it's not a first-choice treatment option.

Reviewed by:
reviewerHope Chang, PharmD, AAHIVP
reviewerMichelle Nguyen, PharmD
Last reviewed on September 23, 2021
basics-icon

What is Chlordiazepoxide/amitriptyline?

What is Chlordiazepoxide/amitriptyline used for?

  • Depression related to anxiety

How Chlordiazepoxide/amitriptyline works

Chlordiazepoxide/amitriptyline is a combination of two medications that affect your mood.

  • Chlordiazepoxide is a benzodiazepine. It slows down activity in your brain to help control anxiety.
  • Amitriptyline is a tricyclic antidepressant. It raises the levels of norepinephrine and serotonin, which are natural chemicals in your brain that can improve your mood.

Drug facts

Common BrandsLimbitrol(brand no longer available)
Drug ClassBenzodiazepine / Tricyclic antidepressant
Controlled Substance ClassificationSchedule IV
Generic StatusLower-cost generic available
AvailabilityPrescription only
warnings-icon

Risks and warnings for Chlordiazepoxide/amitriptyline

Chlordiazepoxide/amitriptyline can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Risks while also taking opioids

  • Risk factors: Taking chlordiazepoxide/amitriptyline with opioids

Black Box Warning Combining chlordiazepoxide/amitriptyline with certain pain medications called opioids can cause a life-threatening interaction that may cause you to be extremely sleepy or stop breathing. It's very important not to combine chlordiazepoxide/amitriptyline with opioids unless you're under close supervision of a healthcare provider. Get emergency help if you feel like you are having trouble breathing or can't wake up very easily after taking chlordiazepoxide/amitriptyline. Educate those around you to keep an eye out for these side effects as well.

Abuse, misuse, dependence, and withdrawal

  • Risk factors: History of substance misuse | Taking with alcohol or certain medications | Taking chlordiazepoxide/amitriptyline for a long time | Stopping chlordiazepoxide/amitriptyline suddenly

Black Box Warning Chlordiazepoxide/amitriptyline is a controlled medication because there's a high risk for abuse and misuse. Your body can also become dependent on the medication, even if you're taking it exactly as directed. Taking chlordiazepoxide/amitriptyline short term can lower these risks. If you have been taking it for a long time, talk to your provider before stopping. Stopping the medication suddenly can lead to serious medical problems, including seizures.

Suicidal thoughts and behavior

  • Risk factors: Age 24 or younger

Black Box Warning Chlordiazepoxide/amitriptyline can raise the risk of suicidal thoughts or behavior. Watch for new or worsening depression, suicidal thoughts or behavior, especially during the first few months of treatment or when your dose changes. Let your healthcare provider know right away if you notice any unusual changes in your mood or behavior while taking this medication.

Bipolar disorder

Sometimes depression can be the first sign of bipolar disorder. Unfortunately, chlordiazepoxide/amitriptyline doesn't treat bipolar and can cause a manic phase. Your provider will screen you for bipolar disorder before starting chlordiazepoxide/amitriptyline. Let them know your full medical history and if anyone in your family has a history of bipolar disorder.

Eye problems

  • Risk factors: Narrow-angle glaucoma

Many antidepressants, including chlordiazepoxide/amitriptyline, can cause eye-related side effects. This can cause eye pain in people who have underlying conditions, such as glaucoma. Let your provider know if you have a history of eye problems and if the medication starts causing vision changes or discomfort.

Heart problems

  • Risk factors: History of heart conditions | Taking high doses of chlordiazepoxide/amitriptyline

Chlordiazepoxide/amitriptyline contains a tricyclic antidepressant, which can cause heart problems, including irregular heart rhythms, heart attack, or stroke. It's more likely to happen if you take higher doses of chlordiazepoxide/amitriptyline and if you have a history of heart conditions.

side-effects-icon

Side effects of Chlordiazepoxide/amitriptyline

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Feeling drowsy or sleepy
  • Dizziness
  • Dry mouth
  • Constipation
  • Bloating
  • Blurry vision

Less Common Side Effects

  • Vivid dreams
  • Sexual dysfunction
  • Shakiness, tremor
  • Confusion
  • Congested or runny nose

Chlordiazepoxide/amitriptyline serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Extreme sleepiness
  • Slowed breathing
  • Suicidal thoughts or behaviors

Source: DailyMed

The following Chlordiazepoxide/amitriptyline side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Blurred vision or other changes in vision

confusion

constipation

difficulty in urinating

dizziness or lightheadedness

eye pain

fainting

irregular heartbeat

irritability

mental depression

nervousness

seeing, hearing, or feeling things that are not there

shakiness

talking, feeling, and acting with excitement

trouble in sleeping

Incidence not known

Actions that are out of control

chest pain or discomfort

decreased interest in sexual intercourse

false or unusual sense of well-being

fast, slow, or irregular heartbeat

inability to have or keep an erection

increased in sexual ability, desire, drive, or performance

increased interest in sexual intercourse

increased sensitivity to sunlight

loss in sexual ability, desire, drive, or performance

pain or discomfort in the arms, jaw, back or neck

redness or other discoloration of skin

severe sunburn

shakiness and unsteady walk

skin rash

sore throat and fever

sweating

swelling of the breasts or breast soreness in males

swelling of the testicles

swelling or inflammation of the mouth

unexpected or excess milk flow from breasts

unsteadiness, trembling, or other problems with muscle control or coordination

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Disorientation

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

headache

loss of consciousness

mood or other mental changes

seizures

trouble breathing, unusual tiredness or weakness

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bloating

clumsiness or unsteadiness

dryness of mouth or unpleasant taste

weight gain

Less common

Diarrhea

nausea or vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See more Chlordiazepoxide/amitriptyline side effects
prices-container

Get your GoodRx coupon

Avg retail price
$60.73(Save 57.80%)
GoodRx discount
$25.63
See prices
pros-and-cons-icon

Pros and cons of Chlordiazepoxide/amitriptyline

Pros

  • Contains two medications in one
  • Works faster than amitriptyline alone
  • Available in a lower-cost generic

Cons

  • Controlled medication; risk of abuse and misuse
  • Not a first-choice treatment option
  • Can cause a lot of side effects
pharmacist-tips-icon

Pharmacist tips for Chlordiazepoxide/amitriptyline

pharmacist
  • It's going to take time for your body to get used to the medication. Taking small doses throughout the day can help. Eventually, you might be able to manage your depression and anxiety with one dose a day, taken at bedtime.
  • If you've been taking chlordiazepoxide/amitriptyline for a while, don't suddenly stop taking it unless your provider tells you to. Suddenly stopping chlordiazepoxide/amitriptyline can cause withdrawal symptoms.
  • Common side effects include sleepiness, dizziness, and vision changes. Don't drive or do anything that requires you to focus until you know how this medication affects you.
  • Dry mouth is a common side effect. Drinking water, sucking on ice cubes or hard candy, and chewing gum can help with this.
  • Store this medication in a safe place. Get medical help or call poison control at 1-800-222-1222 right away if a child accidentally takes it or if anyone takes too much.
faq-icon

Common questions about Chlordiazepoxide/amitriptyline

You can start to feel the effects of chlordiazepoxide/amitriptyline within the first week of starting the medication. Mood symptoms that usually get better first include insomnia (trouble sleeping), feeling guilty or worthless, anxiety, and anorexia (loss of appetite).

Yes, chlordiazepoxide/amitriptyline contains chlordiazepoxide, a benzodiazepine that can be addictive. This is one of the reasons why chlordiazepoxide/amitriptyline isn't a first-choice treatment option.

Avoid alcohol while you're taking chlordiazepoxide/amitriptyline. The combination can make you very tired and has the potential to cause serious breathing problems, which can be fatal.

No, chlordiazepoxide/amitriptyline isn't a sleeping pill. It can help you sleep if your insomnia is caused by your anxiety and depression. However, if you're looking for a sleeping medication, there might be better options.

Weight gain isn't common with chlordiazepoxide/amitriptyline. Still, some people experience weight gain or weight loss with medications that work like amitriptyline. So weight gain might be possible.

educational-icon

How to save using GoodRx

Compare Prices
1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
Select your free coupon
2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
Show coupon to your pharmacist
3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
Get free couponLearn more
dosage-icon

Chlordiazepoxide/amitriptyline dosage

The average cost for 90 tablets of 5mg/12.5mg of Chlordiazepoxide/amitriptyline is $49.99 with a free GoodRx coupon. This is 61.38% off the average retail price of $129.44.
tabletTablet
DosageQuantityPrice as low asPrice per unit
5mg/12.5mg90 tablets$49.99$0.56
10mg/25mg30 tablets$25.63$0.85
See more Chlordiazepoxide/amitriptyline dosage
interactions-icon

Interactions between Chlordiazepoxide/amitriptyline and other drugs

Chlordiazepoxide/amitriptyline may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Chlordiazepoxide/amitriptyline. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

See more Chlordiazepoxide/amitriptyline interactions
cost-icon

How much does Chlordiazepoxide/amitriptyline cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Chlordiazepoxide/amitriptyline (generic)
GoodRx lowest price

$25.63

(save 80.20%)
View prices and coupons
contraindications-icon

Chlordiazepoxide/amitriptyline contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Chlordiazepoxide/amitriptyline will not be safe for you to take.

  • Taking a monoamine oxidase inhibitor (MAOI) medication in the last 14 days
  • Recent heart attack
alternatives-icon

What are alternatives to Chlordiazepoxide/amitriptyline?

There are a number of medications that your doctor can prescribe in place of Chlordiazepoxide/amitriptyline. Compare a few possible alternatives below.
Chlordiazepoxide/amitriptyline
Used for:
  • Depression related to anxiety
$25.63Lowest GoodRx priceView prices
Used for:
$8.80Lowest GoodRx priceView prices
Used for:
$10.98Lowest GoodRx priceView prices
images-icon

Chlordiazepoxide/amitriptyline images

Green-Yellow Round Mylan And 211 - Chlordiazepoxide Hydrochloride/Amitriptyline Hydrochloride 5mg-12.5mg Tablet
This medicine is Green-Yellow, Round Tablet Imprinted With "211" And "Mylan".Green-Yellow Round Mylan And 211 - Chlordiazepoxide Hydrochloride/Amitriptyline Hydrochloride 5mg-12.5mg Tablet

Get savings updates for Chlordiazepoxide/amitriptyline

Receive price alerts, news, and other messages from GoodRx about Chlordiazepoxide/amitriptyline and other healthcare topics and relevant savings offers.

By providing your email, you consent to receive marketing communications from GoodRx, which may include content and/or data related to men's health, women's health, reproductive care, or sexual health. You agree to the GoodRx Terms of Use and acknowledge the Privacy Policy. You can unsubscribe at any time.