The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Children:
- Nausea
- Vomiting
- Diarrhea
- Higher creatine phosphokinase levels
- Dry skin
- Acne-like rash
- Nail infection
- Fever
Adults:
- Rash
- Acne-like rash
- Diarrhea
Less Common Side Effects
Children:
- Stomach pain
- Constipation
- Rash or skin irritation
- Itching
- Muscle, bone, or joint pain
- Mouth sores
- Tiredness
- Headache
- Lower white blood cells
- Hair changes (e.g., hair loss, hair color change)
- Higher liver enzyme levels
- Lower hemoglobin levels
Adults:
- Nausea
- Vomiting
- Muscle, bone, or joint pain
- Swelling of the legs or feet
- Tiredness
- Higher creatine phosphokinase levels
- Higher liver enzyme levels
- Lower hemoglobin levels
Koselugo serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Lower heart function: coughing or wheezing that doesn’t go away, feeling short of breath, swelling in the ankles or feet, feeling tired, fast heartbeat
- Eye problems: blurry vision, vision loss, dark spots in vision (floaters), other changes in vision
- Diarrhea that won’t stop
- Skin problems: widespread rash, raised bumps on your skin, acne-like bumps on your skin, itchy rash, skin peeling, blisters
- Possible muscle problems: muscle aches or pain, muscle spasms, muscle weakness, dark red urine
When do Koselugo possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Acne-like rash
Dry skin
Risk of diarrhea
Risk of nail infection
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.
Source: FDA
The following Koselugo side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
- Blurry vision, vision loss, seeing wavy or bent objects or blind spots with dark, light, or flashing spots
- Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
- Muscle injury—unusual weakness or fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine
- Redness, swelling, and blistering of the skin over hands and feet
- Severe or prolonged diarrhea
- Stomach pain that is severe, does not go away, or gets worse
- Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
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