The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Higher creatinine levels in blood (100%)
- Higher liver enzymes in blood (up to 73%)
- Higher creatine phosphokinase (CPK) levels in blood (79%)
- Other blood test abnormalities (up to 69%)
- Diarrhea (60%)
- Skin that’s sensitive to the sun (46%)
- Nausea (41%)
- Fever (28%)
- Vomiting (24%)
Less Common Side Effects
- Higher blood pressure
- Bleeding
- Vision changes
- Mouth pain or mouth sores
- Chills
- Rash
Note: The side effects listed were reported in people with melanoma taking Cotellic (cobimetinib) and Zelboraf (vemurafenib). Side effects can differ depending on what type of cancer you’re being treated for and whether you’re taking any other anticancer medications.
Cotellic serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Bleeding: blood in urine, blood in stool, vaginal bleeding, sudden and severe headache
- Serious eye problems: sudden and severe eye pain, sudden vision loss
- Serious muscle problems: severe muscle pain or stiffness, dark red or brown urine, sudden muscle weakness
Source: DailyMed
The following Cotellic side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
- Blurry vision, vision loss, seeing wavy or bent objects or blind spots with dark, light, or flashing spots
- Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Muscle injury—unusual weakness or fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine
- Sensitivity to light
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
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