Specialty Drug


Mekinist is part of the Kinase Inhibitors class and treats Melanoma. Kinase inhibitors are used to treat cancers such as leukemia, breast cancer, melanoma, lung cancer, and renal cancer. They are also used in the treatment of rheumatoid arthritis and to prevent organ transplant rejection. They work by stopping cancer cell growth and preventing the spread of the cells. Mekinist is only available as a brand name drug. Compare kinase inhibitors.

Mekinist Side Effects

Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bleeding from the rectum or bloody stools

bleeding gums

blemishes on the skin

blistering, crusting, irritation, itching, or reddening of the skin

bloating or swelling of the face, arms, hands, lower legs, or feet

bloody nose

blurred vision

chest discomfort or pain

cracked, dry, or scaly skin

coughing up blood

decreased urine output


difficulty with breathing or swallowing

dilated neck veins


extreme fatigue


fast, slow, irregular, or pounding heartbeat


increased menstrual flow or vaginal bleeding

irregular breathing

irregular heartbeat

lightheadedness, dizziness, or fainting





pounding in the ears

prolonged bleeding from cuts

rapid weight gain


red or black, tarry stools

red or dark brown urine

redness, swelling, or pain of the skin

scaling of the skin on the hands and feet

tightness in the chest

tingling of the hands and feet

ulceration of the skin

unusual tiredness or weakness

unusual weight gain or loss

Less common




Change in vision

seeing flashes or sparks of light

seeing floating spots before the eyes, or a veil or curtain across part of your vision

stomach cramps, pain, or tenderness

watery or bloody diarrhea

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Burning, itching, and pain in hairy areas, pus at the root of the hair

canker sores

change in taste

dark-colored urine

dry eyes

dry mouth

dry skin

itching, pain, redness, swelling, tenderness, or warmth on the skin

loosening of the fingernails

loss of taste

muscle cramps or spasms

muscle pain or stiffness

redness or soreness around the fingernails

sores, ulcers, or white spots on the lips or tongue or inside the mouth

stomach pain

swelling or inflammation of the mouth


Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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