The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Higher creatinine levels in the blood (93%)
- Higher liver enzymes in the blood (up to 45%)
- Tiredness (43%)
- Nausea (41%)
- Diarrhea (36%)
- Anemia (36%)
- Vomiting (30%)
- Stomach pain (28%)
- Constipation (22%)
- Rash (22%)
- Vision changes (20%)
Less Common Side Effects
- Fever
- Feeling dizzy
- Swelling in the lower leg or ankle
- Higher blood pressure
- Lower white blood cell count
Side effects listed were reported by people taking Mektovi (binimetinib) with Braftovi (encorafenib) for melanoma. Side effects might differ for people with non-small cell lung cancer.
Mektovi serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Blood clots: sudden trouble breathing; chest pain; swelling in one arm or one leg, often with warm, red skin
- Serious lung problems: sudden cough, trouble breathing, tightness in chest, fever
- Bleeding: blood in stool, bleeding from rectum, sudden headache
Source: DailyMed
The following Mektovi side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
- Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
- Blurry vision, vision loss, seeing wavy or bent objects or blind spots with dark, light, or flashing spots
- Dry cough, shortness of breath or trouble breathing
- Eye pain, redness, irritation, or discharge with blurry or decreased vision
- Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Muscle injury—unusual weakness or fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
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