What Are the Best Treatments for Toenail Fungus (Onychomycosis), and How Does It Look?
There are a variety of treatments for toenail fungus, from prescription pills to OTC creams. Experts discuss which toenail fungus treatments are most effective.
Jublia
Used for Nail Fungus
Used for Nail Fungus
Jublia (efinaconazole) is a prescription antifungal medication used to treat toenail fungus in people 6 years and older. It comes as a topical solution that you apply once a day directly to the affected toenail and the skin around it. Treatment usually lasts for almost a year. Common side effects include ingrown toenail and redness, itching, or irritation at the application site.
What is Jublia (efinaconazole)?
What is Jublia (efinaconazole) used for?
- Toenail fungus in people 6 years and older
How Jublia (efinaconazole) works
Jublia (efinaconazole) is an azole antifungal. It works by blocking the fungus from making its protective outer layer. Without this layer, the fungus can’t grow or survive.
When does Jublia (efinaconazole) start working?Time passed since treatment started:
Drug facts
| Common Brands | Jublia |
|---|---|
| Drug Class | Antifungal |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
More on Jublia (efinaconazole) essentials
Side effects of Jublia (efinaconazole)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Ingrown toenail (2%)
- Skin irritation around the application site (2%)
- Blisters around the application site (2%)
Less Common Side Effects
- Pain around the application site
The following Jublia (efinaconazole) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Ingrown nails
- Mild skin irritation, redness, or dryness
Get your GoodRx coupon
$1012.44
GoodRx discount
$791.07
Pros and cons of Jublia (efinaconazole)
Pros
- Used just once a day
- Applied directly to the toenail(s)
- Fewer side effects compared to oral antifungals
Cons
- Doesn't work as well as other antifungals
- Can be messy to apply
- Treatment lasts almost a year
Pharmacist tips for Jublia (efinaconazole)
- Apply Jublia (efinaconazole) to your toenail and the surrounding skin only. Don't take it by mouth, use it in your eyes, or place it inside the vagina.
- Use Jublia (efinaconazole) every day for 48 weeks (about 11 months). Don't stop early, even if your toenails look better, unless your prescriber tells you so. Stopping too soon can make the infection come back stronger.
- Avoid nail polish while using Jublia (efinaconazole). It's unclear whether it will cause this medication to not work as well. Wait until your infection is gone and your nails healed before applying nail polish again.
- Jublia (efinaconazole) can cause some redness, itching, and swelling at the application site. Let your prescriber know if these side effects don't go away.
- Store Jublia (efinaconazole) at room temperature in its original bottle. Keep it away from heat and open flames because the solution is flammable.
How to use Jublia (efinaconazole):
- Before using Jublia (efinaconazole), wash your feet and toes with soap and water and let them dry for at least 10 minutes.
- Use the brush applicator to apply Jublia (efinaconazole) to the affected toenail(s). Cover the whole nail, the cuticle, the skin around the nail, and the skin under the nail tip.
- Let Jublia (efinaconazole) dry fully before putting on socks or shoes. If you're treating your big toenail, apply a second coat shortly after.
- Wash your hands after using Jublia (efinaconazole). Even with the brush, it’s easy to touch the infected nail by accident and spread the fungus to other parts of your body or to other people.
More on Jublia (efinaconazole) tips
Jublia (efinaconazole) dosage
The average cost for 1 bottle of 4ml of 10% of Jublia (efinaconazole) is $791.07 with a free GoodRx coupon. This is 21.86% off the average retail price of $1,012.44. 
Bottle of topical solution
Bottle of topical solution| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 4ml of 10% | 1 bottle | $791.07 | $791.07 |
| 8ml of 10% | 1 bottle | $1,575.90 | $1,575.90 |
Typical dosage for Jublia (efinaconazole)
Apply to the affected toenail(s) once a day for 48 weeks (about 11 months) using the brush applicator. Make sure to apply enough of the solution to cover the entire toenail, the skin under it, and the skin around it.
How much does Jublia (efinaconazole) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Jublia (brand)
$791.07
What are alternatives to Jublia (efinaconazole)?
There are a number of medications that your doctor can prescribe in place of Jublia (efinaconazole). Compare a few possible alternatives below.
News about Jublia (efinaconazole)
How to Apply Jublia, Plus 4 More Tips for Using This Nail Fungus Treatment
You can easily apply Jublia with the brush applicator on the tip of the bottle. Learn how long you should use Jublia and see more tips here.
Answers to 6 Common Questions About Jublia for Toenail Fungus
Jublia (efinaconazole) is an oral antifungal medication that can treat toenail fungus. Here’s how it works, how much it costs, and similar alternatives.
Jublia (efinaconazole) images
