HomeDrug ClassesEnzyme Replacement Therapies

Enzyme Replacement Therapies

Enzyme replacement therapies are used to treat lysosomal storage disease, pancreatic insufficiency, and PKU. They work by increasing levels of certain enzymes in the body to delay symptoms.
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Why are enzyme replacement therapies prescribed?

How are these percentages calculated?
These percentages are created by aggregating the total number of claims for the drugs in this class divided by the # of drugs with a specific indication. It is meant to be representative but may not accurately reflect the actual # of prescriptions written to treat specific condition.

Prices for popular Enzyme Replacement Therapies

Viewing 25 of 36 medications

Creon

as low as

$2,887

PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.

Pancreaze

as low as

$116

Pancreaze (pancrelipase) helps to improve digestion of food by replacing digestive enzymes. This medicine is used to treat health conditions that cause your body to produce less of these enzymes. Pancreaze is more popular than comparable drugs. There are currently no generic alternatives for Pancreaze. GoodRx has partnered with InsideRx and Vivus to reduce the price for this prescription. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Pancreaze is covered by some Medicare and insurance plans.

Zenpep

as low as

$186

PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.

Pertzye

as low as

$165

PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.
SAPROPTERIN treats high phenylalanine levels in people with phenylketonuria (PKU). It works by helping your body break down phenylalanine. This prevents it from building up in the blood. Changes to diet are often combined with this medication.

Viokace

as low as

$372

PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.
LARONIDASE treats mucopolysaccharidosis I (MPS I). It works by replacing an enzyme normally made by the body, which reduces the buildup of complex sugars in the body. This decreases symptoms.
Cerliponase alfa is an enzyme replacement. It is used to slow loss of walking ability in children with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2). This medicine is not a cure.

Cerdelga

as low as

N/A

ELIGLUSTAT treats Gaucher disease. It works by decreasing the amount of fatty substances (lipids) your body makes, which prevents the buildup of lipids in the spleen, liver, and other tissues. This decreases symptoms.
IMIGLUCERASE treats Gaucher disease. It works by decreasing the amount of fatty substances (lipids) your body makes, which prevents the buildup of lipids in the spleen, liver, and other tissues. This decreases symptoms.
IDURSULFASE is used to replace an enzyme that is missing in patients with Hunter syndrome. It is not a cure.

Elelyso

as low as

N/A

Taliglucerase alfa is a man-made form of an enzyme that is missing in patients with Gaucher's disease. It is used to treat the symptoms of Gaucher's disease. It is not a cure.
PEGUNIGALSIDASE ALFA treats Fabry disease. It works by replacing an enzyme normally made by the body, which reduces the buildup fatty substances (lipids) in the eyes, kidneys, heart, and other tissues. This decreases symptoms and the risk of serious health problems.

Endari

as low as

N/A

L-GLUTAMINE prevents the symptoms of sickle cell disease, such as pain crises and acute chest syndrome. It works by protecting your red blood cells from injury and improving blood flow.
AGALSIDASE BETA is used to replace an enzyme that is missing in patients with Fabry disease. It is not a cure.

Galafold

as low as

N/A

MIGALASTAT treats Fabry Disease. It works by replacing an enzyme normally made by the body, which reduces the buildup fatty substances (lipids) in the eyes, kidneys, heart, and other tissues. This decreases symptoms and the risk of serious health problems.

Kanuma

as low as

N/A

SEBELIPASE ALFA treats lysosomal acid lipase deficiency (LAL-D). It works by replacing an enzyme normally made by the body, which reduces the buildup of fatty substances (lipids) in the body. This decreases symptoms.

Lamzede

as low as

N/A

VELMANASE ALFA treats alpha-mannosidosis. It works by replacing an enzyme normally made by the body, which reduces the buildup of complex sugars in the body. This decreases symptoms.

Lumizyme

as low as

N/A

ALGLUCOSIDASE ALFA is a drug that is used to replace an enzyme that is missing in patients with Pompe disease. It is not a cure.

Mepsevii

as low as

N/A

VESTRONIDASE ALFA is an enzyme replacement. It is used to treat the symptoms of Mucopolysaccharidosis type VII (MPS VII; Sly syndrome). This medicine is not a cure.

Naglazyme

as low as

N/A

GALSULFASE is an enzyme replacement. It is used to treat the symptoms of mucopolysaccharidosis VI (also known as MPS VI or Maroteaux-Lamy syndrome). This medicine is not a cure.
AVALGLUCOSIDASE ALFA is an enzyme replacement therapy. It treats late-onset Pompe disease. It is not a cure for late-onset Pompe disease.

Nityr

as low as

N/A

Nityr (nitisinone) slows the breakdown of tyrosine. It is used to treat a rare disease called hereditary tyrosinemia type I. Nityr is less popular than comparable drugs. There are currently no generic alternatives for Nityr. GoodRx has partnered with InsideRx and Cycle Pharmaceuticals to reduce the price for this prescription. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Nityr is covered by some Medicare and insurance plans.
NITISINONE treats tyrosinemia. It works by preventing the break-down of the amino acid tyrosine, which stops the buildup of toxins in your body. This decreases symptoms. Changes to diet are often combined with this medication.

Palynziq

as low as

N/A

PEGVALIASE works to lower phenylalanine levels in the blood. It is used with a special diet to treat phenylketonuria. This medicine is not a cure.
CIPAGLUCOSIDASE ALFA treats Pompe disease. It works by replacing an enzyme normally made by the body, which reduces the buildup of sugar (glycogen) in your muscles. This decreases symptoms.

Revcovi

as low as

N/A

ELAPEGADEMASE is a drug that is used to replace an enzyme that is missing in patients with severe combined immunodeficiency disease associated with adenosine deaminase deficiency. It is not a cure.

Rylaze

as low as

$4,788

ASPARAGINASE ERWINIA CHRYSANTHEMI treats leukemia and lymphoma. It works by slowing down the growth of cancer cells.

Strensiq

as low as

N/A

ASFOTASE ALFA is a drug that is used to replace an enzyme in patients with hypophosphatasia (HPP). It is not a cure.

Sucraid

as low as

N/A

SACROSIDASE treats low sucrase levels in your body. It works by replacing an enzyme (sucrase) normally made by the body. Sucrase helps your body digest and absorb sucrose (sugar) from the food you eat.

Vimizim

as low as

N/A

ELOSULFASE ALFA is an enzyme replacement. It is used to treat the symptoms of Mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome). This medicine is not a cure.

Vistogard

as low as

N/A

URIDINE TRIACETATE treats overdose of or side effects from fluoruracil or capecitabine. It works by protecting healthy cells in your body.

Vpriv

as low as

N/A

VELAGLUCERASE ALFA treats Gaucher disease. It works by decreasing the amount of fatty substances (lipids) your body makes, which prevents the buildup of lipids in the spleen, liver, and other tissues. This decreases symptoms.
OLIPUDASE ALFA treats acid sphingomyelinase deficiency (ASMD). It works by replacing an enzyme normally made by the body, which reduces the buildup of a certain lipid (sphingomyelin) in your liver, spleen, and lungs. This decreases some symptoms of ASMD.
URIDINE TRIACETATE treats orotic aciduria. It works by replacing an enzyme normally made by the body. This decreases symptoms.

javygtor

as low as

$168

SAPROPTERIN treats high phenylalanine levels in people with phenylketonuria (PKU). It works by helping your body break down phenylalanine. This prevents it from building up in the blood. Changes to diet are often combined with this medication.
Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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