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Descovy

emtricitabine / tenofovir alafenamide
Used for HIV Treatment, HIV Prevention
Used for HIV Treatment, HIV Prevention

Descovy (emtricitabine / tenofovir alafenamide), also known as FTC/TAF, is a combination antiretroviral. It's used as part of an antiretroviral therapy (ART) to treat human immunodeficiency virus (HIV) infections in adults and children. It's also preferred for HIV pre-exposure prophylaxis (PrEP). Descovy (emtricitabine / tenofovir alafenamide) works against HIV by stopping the virus from making copies of itself and spreading. Typically, this medication is taken by mouth once daily. Some common side effects of Descovy (emtricitabine / tenofovir alafenamide) include nausea and diarrhea.

Reviewed by:
reviewer
Ally Tsai, PharmD
reviewer
Kristianne Hannemann, PharmD
Last reviewed on November 20, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Descovy (emtricitabine / tenofovir alafenamide)?

What is Descovy (emtricitabine / tenofovir alafenamide) used for?

  • Treatment of HIV infection

  • Prevention of HIV infection (PrEP) through sexual intercourse, except for receptive vaginal sex

How Descovy (emtricitabine / tenofovir alafenamide) works

Descovy (emtricitabine / tenofovir alafenamide) is a combination of two HIV antiretroviral medications: emtricitabine and tenofovir alafenamide. Both medications are nucleoside reverse transcriptase inhibitors (NRTIs). They insert themselves into the genetic material of the virus. As a result, Descovy (emtricitabine / tenofovir alafenamide) prevents HIV from making copies of itself and spreading.

Are you looking for information on Truvada (emtricitabine / tenofovir disoproxil fumarate) instead?

Drug Facts

Common BrandsDescovy
Drug ClassHIV ARV Combo
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

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What are the side effects of Descovy (emtricitabine / tenofovir alafenamide)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (5%)
  • Nausea (4%)
Note: Side effects were reported by people who took Descovy alone for PrEP.

Other Side Effects

  • Headache
  • Feeling tired
  • Belly pain

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Buildup of lactic acid in the blood (lactic acidosis): feeling more tired and weak, belly pain, muscle pain, breathing problems
  • Kidney problems: tiredness, confusion, nausea, urinating less than usual, swelling in your legs, joint or bone pain
  • Liver problems: nausea, vomiting, not feeling hungry, pain in the right side of the stomach, yellowing of the whites of the eyes or skin, dark-colored urine, light-colored stool

Source: DailyMed

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The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Descovy (emtricitabine / tenofovir alafenamide)

thumbs-up

Pros

Only taken once a day

Is a complete regimen for HIV PrEP

Safer for the kidneys and bones compared to Truvada, another PrEP medication

thumbs-down

Cons

Not a complete treatment for HIV (must take one other medication with it)

Can worsen hepatitis B if you stop taking the medication all of a sudden

Requires regular blood work and lab tests to make sure your kidneys are healthy

pharmacist-tips

Pharmacist tips for Descovy (emtricitabine / tenofovir alafenamide)

pharmacist

  • You can take Descovy (emtricitabine / tenofovir alafenamide) with or without food.

    • Make sure to get your routine blood tests done on time before and while you’re taking Descovy (emtricitabine / tenofovir alafenamide). This helps your provider make sure the medication is working for you and not causing side effects.

      • Taking Descovy (emtricitabine / tenofovir alafenamide) can sometimes put you at risk for kidney problems. It's best to avoid other medications that can raise your risk of kidney damage, such as ibuprofen (Advil) and naproxen (Aleve), while you're taking Descovy (emtricitabine / tenofovir alafenamide). Let your provider or pharmacist know what medications you're taking or planning to take, including over-the-counter products and supplements.

        • Speak with your provider before stopping Descovy (emtricitabine / tenofovir alafenamide) or any of your HIV medications. Stopping your HIV medications too soon can cause the virus to spread and become harder to treat. And if you also have hepatitis B, stopping Descovy (emtricitabine / tenofovir alafenamide) suddenly can cause your hepatitis B infection to come back or worsen.

          • If your child is taking Descovy (emtricitabine / tenofovir alafenamide) and you notice major weight changes in your child, make sure to tell the healthcare team. Your child's Descovy (emtricitabine / tenofovir alafenamide) dose might need to be changed with changes in weight (for those weighing less than 77 pounds).

            Tips for taking Descovy (emtricitabine / tenofovir alafenamide) for HIV PrEP (prevention):

            • Let your provider know if you have flu-like symptoms within the past month before you start Descovy (emtricitabine / tenofovir alafenamide) for PrEP. Symptoms of a new HIV infection, such as tiredness, vomiting, diarrhea, fever, joint or muscle aches, sore throat, or night sweats, are similar to flu symptoms.

              • Make sure to get tested for HIV before starting PrEP and at least every 3 months during PrEP. If you become infected with HIV, you'll need different treatment. Taking Descovy (emtricitabine / tenofovir alafenamide) when you test positive for HIV can make the infection harder to treat.

                • While you're taking Descovy (emtricitabine / tenofovir alafenamide), continue to practice safe sex and use condoms to lower your risk of HIV and other sexually transmitted infections (STIs).

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                  faqs

                  Frequently asked questions about Descovy (emtricitabine / tenofovir alafenamide)

                  Is Descovy (emtricitabine / tenofovir alafenamide) used for PrEP?
                  Yes, Descovy (emtricitabine / tenofovir alafenamide) can be used as PrEP, also known as pre-exposure prophylaxis (prevention). According to the US Public Health Service, Descovy (emtricitabine / tenofovir alafenamide) is one of the preferred PrEP medications for people who're at risk of HIV through sex. Keep in mind that it shouldn't be used in females who're at risk of HIV through vaginal sex or through sharing needles. It's not clear how well Descovy (emtricitabine / tenofovir alafenamide) works in these situations. If you're interested in taking medications for PrEP, talk to your provider about the best option for you.
                  How long does it take for Descovy (emtricitabine / tenofovir alafenamide) to work?
                  If you're taking Descovy (emtricitabine / tenofovir alafenamide) to treat HIV, your provider will check your HIV levels through blood tests to keep track of how well this medication is working for you. In general, people who take HIV medications as directed should see their viral load drop to an undetectable level within half a year of starting treatment. If you're taking Descovy (emtricitabine / tenofovir alafenamide) for PrEP as prescribed, research shows that it should lower your risk of getting HIV by 99% after a week. Talk with your provider if you've more questions about how well Descovy (emtricitabine / tenofovir alafenamide) works.
                  Is Descovy (emtricitabine / tenofovir alafenamide) effective for PrEP after 3 days?
                  If you're taking Descovy (emtricitabine / tenofovir alafenamide) for PrEP, you need to take it daily for at least a week to have maximum protection. It won't be as effective for PrEP if you only take it for 3 days. In addition, Descovy (emtricitabine / tenofovir alafenamide) won't work to protect you against HIV if you've already been exposed to HIV.
                  Can I take Descovy (emtricitabine / tenofovir alafenamide) after exposure?
                  No, you shouldn't take Descovy (emtricitabine / tenofovir alafenamide) after HIV exposure since it hasn't been studied for PEP (post-exposure prophylaxis or prevention). It's not clear whether this medication'll work well to stop the virus. Talk to your child's provider to learn more about PEP versus PrEP.
                  Does Descovy (emtricitabine / tenofovir alafenamide) cause weight gain?
                  People who took Descovy (emtricitabine / tenofovir alafenamide) on its own for PrEP didn't report weight gain as a side effect. But you might gain weight if you're taking Descovy (emtricitabine / tenofovir alafenamide) along with other HIV medications to treat HIV. For example, researchers found that people who took tenofovir alafenamide (an active ingredient in Descovy) with an integrase inhibitor (e.g., Tivicay (dolutegravir)) were more likely to gain weight compared to other antiretroviral regimens. Keep in mind that this combination of medications (Descovy (emtricitabine / tenofovir alafenamide) and Tivicay) is one of the preferred treatment regimens for people with HIV starting therapy for the first time. Talk to your provider if you're concerned about this side effect.
                  Can females take Descovy (emtricitabine / tenofovir alafenamide) for PrEP?
                  Females can take Descovy (emtricitabine / tenofovir alafenamide) for PrEP, but note that this medication is not effective for females who're at risk of HIV through receptive vaginal sex. It's not clear how well Descovy (emtricitabine / tenofovir alafenamide) works in this situation. Talk to your provider to decide what is the best PrEP option for you.
                  What's the difference between Descovy (emtricitabine / tenofovir alafenamide) and Truvada?
                  Descovy (emtricitabine / tenofovir alafenamide) and Truvada (emtricitabine / tenofovir disoproxil fumarate) are both combination medications that are approved to treat and prevent HIV infection. One of the main differences is that Truvada can be used to prevent HIV infection in people who're at risk through sex or injection drug use. But Descovy (emtricitabine / tenofovir alafenamide) isn't approved to prevent HIV infection from sharing injection supplies or specifically from receptive vaginal sex (the medication wasn't studied in these situations). In addition, research also suggests that Descovy (emtricitabine / tenofovir alafenamide) is less likely to cause side effects to your kidneys and bones than Truvada. Talk to your provider to discuss which one is the right treatment option for you.
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                  What are the risks and warnings for Descovy (emtricitabine / tenofovir alafenamide)?

                  Descovy (emtricitabine / tenofovir alafenamide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Worsening of hepatitis B infection

                  • Risk factors: Have hepatitis B and HIV | Stopping Descovy (emtricitabine / tenofovir alafenamide) | Severe liver problems

                    Before you start Descovy (emtricitabine / tenofovir alafenamide), your provider will test you for hepatitis B virus (HBV). If you have HBV, suddenly stopping Descovy (emtricitabine / tenofovir alafenamide) might make your liver condition worse (also called an HBV flare-up). Don't stop taking Descovy (emtricitabine / tenofovir alafenamide) without talking with your provider first. Make sure to get your refills on time so that your treatment isn't interrupted. If you need to stop taking Descovy (emtricitabine / tenofovir alafenamide), your provider might follow up with you for several months after you stop treatment. Your provider will order blood work to check your liver for an HBV flare-up.

                    risk-warning

                    PrEP only for people who test negative for HIV

                    • Risk factors: Undetected HIV infection while taking Descovy (emtricitabine / tenofovir alafenamide) for PrEP

                      Descovy (emtricitabine / tenofovir alafenamide) can be used as PrEP. PrEP is for people who don't have HIV to help prevent infection before they're potentially exposed to the virus through sex. You'll need to test for HIV to make sure that you don't have HIV before you start PrEP and at least every 3 months while you're taking Descovy (emtricitabine / tenofovir alafenamide). If you test positive for HIV, your provider will need to change your medications. Taking Descovy (emtricitabine / tenofovir alafenamide) alone isn't enough to treat HIV and can make your infection more difficult to treat.

                      risk-warning

                      Kidney problems

                      • Risk factors: History of kidney problems | Taking other medications known to harm kidneys

                        Some people taking Descovy (emtricitabine / tenofovir alafenamide) have had kidney problems. To prevent kidney injury, it's recommended that you avoid taking other medications that can also harm the kidneys, like high doses of nonsteroidal anti-inflammatory drugs (NSAIDs). Before starting and during treatment with Descovy (emtricitabine / tenofovir alafenamide), your provider will order blood work or urine tests to check on your kidneys. Let your provider know right away if you experience bone or muscle pain, pain in your arms or legs, and general weakness that doesn't go away. These might be signs of kidney problems.

                        risk-warning

                        Overactive immune system

                        Taking Descovy (emtricitabine / tenofovir alafenamide) can cause changes to your immune system called immune reconstitution syndrome. This medical condition happens when your immune system becomes more active after you start Descovy (emtricitabine / tenofovir alafenamide). Your immune system begins to fight off different infections that it was too weak to fight off before you started treatment. In rare cases, your immune system might improve so much with treatment that it starts to attack normal cells in your body (autoimmune). You can develop immune reconstitution syndrome as early as during the first few weeks of taking Descovy (emtricitabine / tenofovir alafenamide) or many months later. Tell your healthcare provider right away if you start having any new symptoms, such as fever, pain, hair loss, bulging eyes, or sweating, after you start Descovy (emtricitabine / tenofovir alafenamide).

                        risk-warning

                        Liver problems and lactic acidosis

                        Rarely, people who take medications containing NRTIs, such as Descovy (emtricitabine / tenofovir alafenamide), have reported liver problems, like fatty liver disease. Descovy (emtricitabine / tenofovir alafenamide) can also cause a buildup of lactic acid in the blood (lactic acidosis). Both conditions can be life-threatening.

                        Make sure to get blood tests done while you take Descovy (emtricitabine / tenofovir alafenamide) so your provider can check for these harmful side effects and make sure the medication is still safe to take. Talk with your provider right away if you experience signs and symptoms of liver damage, such as upper right stomach pain, yellowing of the skin or whites of the eyes, or dark urine. Also, let your provider know if you have symptoms of lactic acidosis, such as feeling weak, muscle pain, and trouble breathing.

                        risk-warning

                        Interaction with other medications

                        Taking certain medications for HIV (e.g., Aptivus (tipranavir), ritonavir (Norvir)), seizures (e.g., carbamazepine (Tegretol)), bacterial infections (e.g., rifampin (Rifadin)), or herbal supplements (e.g., St. John's wort) can lower the amount of Descovy (emtricitabine / tenofovir alafenamide) in your body. This can cause the HIV virus to spread and become harder to treat. Because of the potential for drug interactions with Descovy (emtricitabine / tenofovir alafenamide), tell your provider and pharmacist about all the medications you take or plan to take. They can make sure your medications are safe to take together.

                        dosage

                        Descovy (emtricitabine / tenofovir alafenamide) dosage forms

                        Typical dosing for Descovy (emtricitabine / tenofovir alafenamide)

                        Treatment of HIV

                        • Adults and children who weigh at least 77 pounds: The typical dose is 1 tablet (200 mg/25 mg of emtricitabine/tenofovir alafenamide) by mouth once daily.

                        • Children who weigh 30 to under 77 pounds: The typical dose is 120 mg/15 mg (emtricitabine / tenofovir alafenamide) by mouth once daily.

                        Prevention of HIV (PrEP)

                        • Adults and children who weigh at least 77 pounds: The typical dose is 200 mg/25 mg (emtricitabine/tenofovir alafenamide) by mouth once daily.

                        More on Descovy (emtricitabine / tenofovir alafenamide) dosage forms

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                        contraindications-icon

                        Descovy (emtricitabine / tenofovir alafenamide) contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Descovy (emtricitabine / tenofovir alafenamide) will not be safe for you to take.

                        • For HIV PrEP: People who have HIV (tested positive for HIV) or aren't sure if they're infected with HIV

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                        latest news

                        What is the latest news about Descovy (emtricitabine / tenofovir alafenamide)?

                        The PrEP medication Descovy is a safe, FDA-approved method to prevent HIV infection. Here’s how three people explain what taking Descovy for PrEP is like.

                        What Is It Like to Take Descovy for HIV Prevention?

                        The PrEP medication Descovy is a safe, FDA-approved method to prevent HIV infection. Here’s how three people explain what taking Descovy for PrEP is like.
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                        Descovy is a generally well-tolerated PrEP treatment, but it may cause side effects like nausea and diarrhea in some people. Read more about Descovy side effects.

                        7 Descovy Side Effects: What to Expect With PrEP

                        Descovy is a generally well-tolerated PrEP treatment, but it may cause side effects like nausea and diarrhea in some people. Read more about Descovy side effects.
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                        Truvada vs. Descovy for PrEP

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                        Descovy (emtricitabine / tenofovir alafenamide) images

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                        References

                        Best studies we found

                        Anderson, P. L., et al. (2012). Emtricitabine-tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men. Science Translational Medicine.

                        Centers for Disease Control and Prevention. (2024). What is PrEP

                        Clinical Info HIV.gov. (n.d.). Nucleoside reverse transcriptase inhibitor (NRTI).

                        View All References (7)

                        Clinical Info HIV.gov. (2022). Initial combination antiretroviral regimens for people with HIV.

                        Gilead Sciences, Inc. (2022). Descovy- emtricitabine and tenofovir alafenamide tablet [package insert]. DailyMed.

                        Lake, J. E., et al. (2021). Impact of Integrase inhibitors and tenofovir alafenamide on weight gain in people with HIV. Current Opinion in HIV and AIDS.

                        MedlinePlus. (2017). Fatty liver disease.

                        National Institute of Allergy and Infectious Diseases. (2024). 10 things to know about HIV suppression.

                        US Public Health Service. (2021). Preexposure prophylaxis for the prevention of HIV infection in the United States.

                        Thapa, S., et al. (2023). Immune reconstitution inflammatory syndrome. StatPearls.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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