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Cresemba

isavuconazonium
Used for Fungal Infection
Used for Fungal Infection

Cresemba (isavuconazonium) is an azole antifungal. It's used to treat invasive aspergillosis and mucormycosis fungal infections in adults and children. Cresemba (isavuconazonium) capsules can be take by people ages 6 years and older (weighing at least 16 kg). Cresemba (isavuconazonium) intravenous (IV) infusions can be given to people ages 1 year and older. Treatment typically starts off with a loading dose taken every 8 hours for 2 days, then a maintenance dose taken once per day. Some common side effects include nausea, vomiting, diarrhea, and stomach pain.

Last reviewed on August 5, 2024
basics-icon

What is Cresemba (isavuconazonium)?

What is Cresemba (isavuconazonium) used for?

Serious fungal infections that have spread to the bloodstream:

How Cresemba (isavuconazonium) works

Cresemba (isavuconazonium) is an azole antifungal medication that works by stopping the fungus from being able to make a protective covering. This causes the fungus to not grow or survive.

Drug Facts

Common BrandsCresemba
Drug ClassAntifungal
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Cresemba (isavuconazonium)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Adults:
  • Nausea (28%)
  • Vomiting (25%)
  • Diarrhea (24%)
  • Low potassium levels (19%)
  • Stomach pain (17%)
  • Headache (17%)
  • Elevated liver enzymes (17%)
  • Trouble breathing (17%)
  • Swelling of the limbs (15%)
  • Constipation (14%)
  • Fatigue (11%)
  • Trouble sleeping (11%)
  • Back pain (10%)
  • Kidney failure (10%)
Children:
  • Diarrhea (26%)
  • Stomach pain (23%)
  • Vomiting (21%)
  • Elevated liver enzymes (18%)
  • Rash (14%)
  • Nausea (13%)
  • Headaches (12%)

Other Side Effects

  • Low appetite
  • Anxiety
  • Agitation, confusion
  • Rash
  • Itching
  • Chest pain
  • Injection site reaction
  • Heartburn

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic and skin reactions: hives, rash, blisters, swelling of the lips or tongue, difficulty breathing, skin reddening, skin scaling, skin itching
  • Liver damage: nausea, vomiting, feeling tired, stomach pain, yellowing of your skin or whites of your eye (jaundice), dark-colored urine, pale-colored stool

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Cresemba (isavuconazonium)

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Pros

Works well to treat aspergillosis and mucormycosis

Available as a capsule and an injection

Only has to be taken once a day (after the first 2 days)

IV infusion can be given to children as young as 1 years old

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Cons

Not safe while pregnant or breastfeeding

Can interact with other medications

Rare risk of serious liver problems

Only available as brand-name medication

pharmacist-tips

Pharmacist tips for Cresemba (isavuconazonium)

pharmacist
  • You can take Cresemba (isavuconazonium) with or without food. But stomach-related side effects (e.g., nausea, vomiting, diarrhea, stomach pain, indigestion) are common, so taking it with food can help ease or prevent these side effects from happening.

    • Swallow Cresemba (isavuconazonium) capsules whole. Don’t open, crush, dissolve, or chew the capsules. If you're having trouble swallowing the capsules, let your prescriber know. They might switch you to a different antifungal medication.

      • If you have a nasogastric (NG) tube (a type of feeding tube), your prescriber can order the Cresemba (isavuconazonium) injection to be given through the feeding tube.

        • Take Cresemba (isavuconazonium) exactly as prescribed. Make sure to finish your treatment course, even if you're feeling better. Stopping the medication earlier than prescribed can make your infection come back and become more difficult to treat.

          • Rarely, the IV version of Cresemba (isavuconazonium) can cause infusion-related reactions, such as low blood pressure, trouble breathing, chills, dizziness, tingling, or numbness. Let your prescriber know if you're experiencing any of these.

            • Contact your prescriber if you develop other symptoms of an illness or if your symptoms become worse. This could be a sign that you're infected with a virus or bacteria instead of a fungus. If so, you'll need to a different medication than Cresemba (isavuconazonium) because it's only used to treat certain fungal infections.

              faqs

              Frequently asked questions about Cresemba (isavuconazonium)

              Does Cresemba (isavuconazonium) cause hair loss?
              Though not common, few people who took Cresemba (isavuconazonium) in clinical studies have reported hair loss (alopecia). But it's unclear whether the hair loss was caused by Cresemba (isavuconazonium) or a result of other factors. In general, taking an azole antifungal over the course of weeks to months have been linked to hair loss. But limited research suggests Cresemba (isavuconazonium) is less likely to cause alopecia compared to some other azole antifungals, like voriconazole (Vfend). If you notice hair loss while you're taking Cresemba (isavuconazonium), contact your healthcare professional (HCP).
              What are some common Cresemba (isavuconazonium) side effects?
              Cresemba (isavuconazonium) commonly causes stomach-related side effects, including nausea, vomiting, diarrhea or constipation. If you experience these side effects, taking Cresemba (isavuconazonium) with food can help. Also, try eating smaller meals more often throughout the day, and avoiding spicy or greasy foods. It's important to stay hydrated by drinking enough water throughout the day because this can help relieve constipation and prevent dehydration. Let your care team know if the side effects are making it difficult for you to get through the day; they can talk with you about your options. But don't stop taking Cresemba (isavuconazonium) without first talking with your HCP because doing so can worsen your infection.
              How does Cresemba (isavuconazonium) compare to voriconazole?
              Cresemba (isavuconazonium) and voriconazole (Vfend) are both azole antifungals that are approved to treat invasive aspergillosis (IA). Both medications are available in oral and IV forms, but Cresemba (isavuconazonium) is taken once daily (after the loading dose on the first 2 days), whereas voriconazole (VFend) is taken twice per day. A study comparing both medications found that they work similarly well in treating IA, but Cresemba (isavuconazonium) is less likely to cause serious side effects. Talk to your care team if you have more questions about the differences between both medications.
              Is Cresemba (isavuconazonium) safe while pregnant or breastfeeding?
              No, Cresemba (isavuconazonium) should be avoided during pregnancy due to the potential for severe development problems in babies. If you're able to become pregnant, your HCP will likely recommend that you use birth control while taking Cresemba (isavuconazonium) and for 28 days after the last dose. In addition, there aren't any studies to know if Cresemba (isavuconazonium) is safe to take while breastfeeding, so using a different medication is typically recommended. If you're pregnant, thinking of becoming pregnant, or are breastfeeding, let your HCP know right away. They'll look into switching you to a safer option.
              Can you drink alcohol while taking Cresemba (isavuconazonium)?
              Don't drink alcohol until you've finished your treatment course of Cresemba (isavuconazonium). In general, you should avoid drinking alcohol while taking an antibiotic or while fighting an infection. Drinking alcohol can weaken your immune system and make it harder to recover from an infection. Additionally, drinking alcohol while taking Cresemba (isavuconazonium) raises your risk for stomach-related (e.g., nausea, vomiting, diarrhea) as well as the risk for liver problems.
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              What are the risks and warnings for Cresemba (isavuconazonium)?

              Cresemba (isavuconazonium) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Liver damage

              • Risk factors: Liver problems | Alcohol use | Current liver problems | Certain blood cancers | Children | Taking other medications that cause liver problems

                People who took Cresemba (isavuconazonium) have developed liver irritation. Most of the time, this isn't serious and they were able to continue treatment with Cresemba (isavuconazonium). But rarely, people have reported life-threatening liver problems. Because of this risk, your prescriber might order blood tests before you start and during treatment to check your liver health. Also, it's recommended to limit or avoid alcohol because it can also cause liver damage. Get medical attention right away if you notice yellowing of your skin or the whites of your eyes; stool changes; dark or brown urine; swelling of your stomach; stomach pain; or confusion. Your prescriber might ask you to stop taking Cresemba (isavuconazonium) in order to prevent further liver damage.

                risk-warning

                Severe allergic and skin reactions

                People have reported infusion-related reactions while receiving Cresemba (isavuconazonium) through IV infusion. Let your healthcare team know if you experience symptoms such as trouble catching your breath, chills, and dizziness while receiving your dose; they'll need to stop the infusion.

                Though rare, people have reported severe allergic reactions to Cresemba (isavuconazonium). Symptoms included facial swelling, hives, and anaphylaxis (e.g., closing of the throat). If you notice difficulty breathing; a choking sensation; dizziness; fast heartbeat; nausea; or swelling around your eyes, lips, or tongue after taking Cresemba (isavuconazonium), get medical attention right away.

                Also rare, people have reported severe skin reactions, such as Stevens-Johnson syndrome (SJS), while receiving other azole antifungals. If you notice changes in your skin, such as rash, blisters, or skin reddening or peeling, and have a fever and swollen lymph nodes, seek medical help right away.

                risk-warning

                Harm during pregnancy

                Cresemba (isavuconazonium) should be avoided during pregnancy due to the potential for severe development problems in babies. If you're able to get pregnant, it's recommended to use birth control while taking Cresemba (isavuconazonium) and for at least 28 days after the last dose. Let your prescriber know right away if you're pregnant or thinking of becoming pregnant.

                risk-warning

                Serious medication interactions

                There are some medications that can have serious interactions with Cresemba (isavuconazonium). For example, you can't take Cresemba (isavuconazonium) with medications like rifampin (Rifadin) or phenytoin (Dilantin) because these medications can lower the level of Cresemba (isavuconazonium) and cause it to not work well to fight your infection. Also, you can't take Cresemba (isavuconazonium) with medications like ketoconazole because doing so raises the level of Cresemba (isavuconazonium) and puts you at higher risk for side effects. Before you start Cresemba (isavuconazonium), let your about all the medications you're taking so they can help you check for interactions.

                dosage

                Cresemba (isavuconazonium) dosage forms

                Typical dosing for Cresemba (isavuconazonium)

                Cresemba (isavuconazonium) is available as a capsule taken by mouth and as an infusion through the veins (IV). The capsule is can be taken by people ages 6 years and older (who weigh 16 kg or greater) and the IV infusion can be given to people ages 1 year and older.

                • Adults: The typical starting dose is 372 mg infused IV or taken by mouth every 8 hours for 6 doses. After that, the typical maintenance dose is 372 mg IV or by mouth once per day.

                • Children: Your child's healthcare provider will calculate the dose based on your child's age, weight, and if they're receiving the IV infusion or the capsule. The typical starting dose is infused IV or taken by mouth every 8 hours for 6 doses. After that, the maintenance dose is given IV or by mouth once per day.

                contraindications-icon

                Cresemba (isavuconazonium) contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Cresemba (isavuconazonium) will not be safe for you to take.
                alternatives

                What are alternatives to Cresemba (isavuconazonium)?

                There are a number of medications that your doctor can prescribe in place of Cresemba (isavuconazonium). Compare a few possible alternatives below.
                Cresemba (isavuconazonium)
                Used for:

                Serious fungal infections that have spread to the bloodstream:

                Used for:
                • Fungal infections in people with a fever and a low number of white blood cells

                • Candidemia (a fungal infection in your blood) and other infections caused by Candida

                • Candidiasis of the esophagus (thrush in the esophagus)

                • Invasive aspergillosis (a serious fungal infection affecting multiple areas of the body)

                $975.65 Lowest GoodRx priceView Prices
                Used for:
                • Fungal infections in people with a fever and a low number of white blood cells

                • Cryptococcal meningitis in people with HIV

                • People with severe fungal infections caused by Aspergillus, Candida, or Cryptococcus who have already tried other antifungals or cannot take other antifungals

                • Black fever (visceral leishmaniasis)

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                References

                Best studies we found
                View All References (10)

                Centers for Disease Control and Prevention. (2024). Symptoms of aspergillosis.

                Drugs and Lactation Database (LactMed®). (2024). Isavuconazole. National Institute of Child Health and Human Development.

                Herrick, E. J., et al. (2024). Antifungal ergosterol synthesis inhibitors. StatPearls.

                Jenks, J. D., et al. (2018). Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: Design, development, and place in therapy. Drug Design, Development and Therapy.

                Maetens, J. A., et al. (2016). Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): A phase 3, randomised-controlled, non-inferiority trial. The Lancet.

                Nwankwo, L., et al. (2022). Experience of isavuconazole as a salvage therapy in chronic pulmonary fungal disease. Journal of Fungi.

                Patel, M. A., et al. (2021). Common antifungal drugs in pregnancy: Risks and precautions. Journal of Obstetrics and Gynaecology of India.

                Rakhshan, A., et al. (2023). Hepatotoxicity induced by azole antifungal agents: A review study. Iranian Journal of Pharmaceutical Research.

                Rudic, B., et al. (2014). Short QT syndrome - Review of diagnosis and treatment. Arrhythmia & Electrophysiology Review.

                Vergidis, P. (2023). Mucormycosis. Merck Manual Consumer Version.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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