Key takeaways
Zonisamide (Zonegran, Zonisade) and Rufinamide (Banzel) are both antiepileptic medications, but they are used for different types of seizures. Zonisamide is used to control partial-onset seizures in people with epilepsy and is available in both capsule and oral suspension forms. Rufinamide, on the other hand, is specifically used for seizures linked to Lennox-Gastaut syndrome (LGS) and is available as tablets and an oral suspension. Zonisamide can be taken once a day, while Rufinamide must be taken twice a day with food for full absorption. Zonisamide capsules are available as a lower-cost generic, but Rufinamide can be expensive even in its generic form. Both medications can cause drowsiness and dizziness, but Rufinamide also has a risk of heart rhythm problems. Additionally, Zonisamide should not be taken if you have a sulfa allergy, while Rufinamide is contraindicated for those with Familial Short QT syndrome.
