Key takeaways
Ziana (clindamycin/tretinoin) and benzoyl peroxide are both used to treat acne, but they work in different ways and have some key differences. Ziana is a combination of clindamycin, an antibiotic that kills acne-causing bacteria, and tretinoin, a retinoid that promotes healthy skin growth and reduces oil. Ziana is a gel available by prescription and can take up to 12 weeks to show improvement. Benzoyl peroxide, on the other hand, is an antiseptic that prevents bacteria from growing and is available over-the-counter in various forms, such as gels, creams, and washes. It generally starts to work in about 4 weeks but can take up to 3 months for full effects. Ziana is typically used once a day at bedtime, while benzoyl peroxide is applied 1 to 3 times daily depending on the form. Benzoyl peroxide is more affordable and accessible, whereas Ziana might be a better option for those who haven't had success with other treatments. Both medications can make your skin more sensitive to sunlight, so it's important to use sunscreen and protective clothing.
