Key takeaways
Fluticasone (Xhance) and fluticasone (Flonase) are both corticosteroid nasal sprays used to treat nasal conditions. They both help reduce inflammation in the nose, but they are used for different purposes. Xhance is specifically FDA-approved for treating chronic rhinosinusitis with or without nasal polyps in adults, while Flonase is used to relieve allergy symptoms like congestion, runny nose, and sneezing. Xhance is a prescription-only medication and uses a unique delivery system with a mouthpiece to help the medication reach high in the nasal passages. In contrast, Flonase is available both by prescription and over-the-counter and uses a traditional nasal spray method. Xhance is typically dosed as 1 or 2 sprays per nostril twice daily, while Flonase is typically 1 spray per nostril twice daily or 2 sprays per nostril once daily. Xhance is only available as a brand-name medication, whereas Flonase has generic versions. Common side effects of Xhance include nosebleeds and nasal irritation, while Flonase can cause headaches and sore throats.
