Key takeaways
Xelstrym (dextroamphetamine) and Vyvanse (lisdexamfetamine) are both stimulant medications used to treat attention deficit-hyperactivity disorder (ADHD). They work by increasing levels of certain chemicals in the brain, like norepinephrine, dopamine, and serotonin. However, they differ in several ways. Xelstrym is a transdermal patch applied to the skin, while Vyvanse is taken orally as a capsule or chewable tablet. Xelstrym is only approved for ADHD, whereas Vyvanse is also approved for treating moderate-to-severe binge eating disorder (BED) in adults. Xelstrym is typically applied once daily and lasts up to 9 hours. Vyvanse is taken once daily in the morning and typically lasts throughout the day. Common side effects for both include difficulty sleeping and loss of appetite, but Vyvanse may also cause dry mouth and stomach pain. Both medications have a risk of misuse and dependency and are controlled substances.
