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Voltaren gel vs. Naprosyn

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Voltaren gel (diclofenac) and Naprosyn (naproxen) are both non-steroidal anti-inflammatory drugs (NSAIDs) used to relieve pain and inflammation, but they differ in their forms and specific uses. Voltaren gel is a topical medication applied directly to the skin, primarily for osteoarthritis pain in smaller joints like the hands, wrists, and knees. In contrast, Naprosyn is an oral medication taken by mouth and is used for a broader range of conditions, including rheumatoid arthritis, osteoarthritis, gout, and menstrual cramps. While Voltaren gel is available over-the-counter in a 1% gel form, Naprosyn requires a prescription. Voltaren gel can cause skin irritation and has a lower risk of systemic side effects compared to oral NSAIDs, but it still carries risks like heart attack and stroke. Naprosyn, on the other hand, can cause stomach bleeding, heart issues, and kidney problems, and it should be taken with food to minimize stomach-related side effects. Both medications should be used cautiously, especially if you have a history of heart, liver, or kidney problems.

Diclofenac sodium topical gel

(Voltaren gel)

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Naproxen

(Naprosyn)

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Summary for Voltaren gel

Prescription or over-the-counter

Topical diclofenac is a non-steroidal anti-inflammatory drug (NSAID). It helps temporarily relieve pain from osteoarthritis in adults. This medication comes as a %1 gel as generic and brand name (commonly Voltaren gel). It's available over the counter. There are also topical solutions of various strengths by prescription only. You apply the medication to the skin of the affected joints, up to 2 or 4 times daily. The exact dosage and number of times per day depends on which form you use. Side effects include dry skin, skin irritation, and itching. More serious risks include high blood pressure and stomach issues, but the potential is low.

Indications for Voltaren gel

  • Pain from osteoarthritis of the knee - topical solutions and 1% gel
  • Pain from osteoarthritis of small joints, such as hands, wrists, elbows, or feet - 1% gel only

Pros and Cons for Voltaren gel

Pros

  • Can help relieve specific areas of osteoarthritis pain
  • 1% gel available over the counter without a prescription
  • Less serious side effects than taking diclofenac pills by mouth

Cons

  • Doesn't provide relief right away
  • Can be inconvenient to use because you need to wait for the medication to dry before putting on clothing
  • Not for minor sprains, bruises, or other joints (like the back or hip)

Common Side Effects for Voltaren gel

1% gel:

  • Skin irritation (e.g., redness, rash, itchiness; 4%)

1.5% solution:

  • Dry skin (32%)
  • Skin irritation (9%)
  • Indigestion (8%)
  • Stomach pain (6%)

Warnings for Voltaren gel

  • Risk of heart attack and stroke
  • Risk of stomach ulcers and stomach bleeding
  • Liver damage
  • High blood pressure
  • Swelling and risk of heart failure
  • Kidney damage
  • High potassium levels
  • Worsening asthma in certain people
  • Severe allergic reaction or skin reaction
  • Risk of general bleeding and anemia
  • Higher risk of serious side effects when used together with oral NSAIDs
  • Harm to an unborn baby

Summary for Naprosyn

Prescription only

Prescription-strength naproxen (Naprosyn) is a non-steroidal anti-inflammatory drug (NSAID). It can be taken by adults and children to relieve pain and symptoms of certain conditions that cause inflammation, such as rheumatoid arthritis, osteoarthritis, or gout. Naproxen (Naprosyn) works by blocking specific proteins that cause inflammation and pain. Naproxen (Naprosyn) comes as tablet and liquid suspension that are taken by mouth, typically 2 to 3 times per day. Some common side effects include heartburn, stomach pain, and nausea.

Indications for Naprosyn

Pros and Cons for Naprosyn

Pros

  • Works well for treating pain and inflammation
  • Effects last longer than other NSAIDs, such as ibuprofen (Advil)
  • Available as a liquid for people who have a hard time swallowing pills

Cons

  • Can cause stomach bleeding or stomach ulcers
  • Not safe to take after 20 weeks of pregnancy
  • Might not be the best option if you're 65 years or older, or have kidney, heart, liver, or bleeding problems

Common Side Effects for Naprosyn

The following side effects were reported in 3-9% of people in clinical studies:

  • Heartburn
  • Stomach pain
  • Constipation
  • Nausea
  • Dizziness
  • Drowsiness
  • Headache
  • Itchy skin
  • Bruising
  • Ringing in the ears
  • Swelling
  • Shortness of breath

Warnings for Naprosyn

  • Stomach bleeding
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Kidney damage
  • Liver problems
  • Severe allergic reactions
  • Not for use in pregnant or breastfeeding females

Prices with our coupons for Voltaren gel vs. Naprosyn

Price Card Drug Icon
Diclofenac Sodium1 tube / 100g of 1%
$12.25$26.79
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Price Card Drug Icon
Naproxen30 tablets / 500mg
$11.42$18.10
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