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Vistaril vs. Buspar

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Hydroxyzine (Vistaril) and buspirone (Buspar) are both used to treat anxiety, but they have some key differences. Hydroxyzine is an antihistamine that can also help with itching and allergies, while buspirone is specifically an antianxiety medication. Hydroxyzine works quickly, often within 15 to 30 minutes, but it can cause drowsiness and is not recommended for long-term use. In contrast, buspirone takes about 2 to 4 weeks to show effects and is taken twice daily. Buspirone has a lower risk of dependency and withdrawal symptoms compared to other anxiety medications, but it can cause dizziness and nausea. Hydroxyzine is available in both pill and liquid forms, while buspirone is only available as a pill.

Hydroxyzine pamoate

(Vistaril)

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Buspirone

 

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Summary for Vistaril

Prescription only

Hydroxyzine pamoate (Vistaril) is a prescription antihistamine. It's taken by adults and children to treat anxiety and to ease itching from allergies. It's also used as a sleep aid (sedative) before and after general anesthesia. Hydroxyzine pamoate (Vistaril) comes as a capsule that's taken by mouth up to 4 times daily. Some common side effects of this medication include sleepiness, dry mouth, and headache. It's best to avoid drinking alcohol while taking hydroxyzine pamoate (Vistaril) because doing so can worsen drowsiness.

Indications for Vistaril

Pros and Cons for Vistaril

Pros

  • Helps relieve itching and anxiety within 30 minutes
  • An option for children
  • Taken by mouth

Cons

  • Sleepiness and dizziness are common side effects
  • Can rarely cause sexual side effects
  • Might need to take up to 4 times a day

Common Side Effects for Vistaril

Warnings for Vistaril

  • Sleepiness
  • Heart rhythm problems (QT prolongation)
  • Higher risk of side effects in people over 65
  • Severe allergic and skin reactions

Summary for Buspar

Prescription only

Buspirone tablets help manage and relieve anxiety in adults. It belongs to a drug class called anxiolytics (or anti-anxiety medications). The tablets are taken by mouth, typically twice daily. Common side effects are dizziness, nausea, headache, and nervousness. Buspirone isn't a controlled substance. The brand name Buspar is no longer available, but you can get the generic buspirone tablets.

Indications for Buspar

Pros and Cons for Buspar

Pros

Cons

Common Side Effects for Buspar

  • Dizziness (12%)
  • Drowsiness (10%)
  • Nausea (8%)
  • Headache (6%)
  • Nervousness (5%)

Warnings for Buspar

  • Serotonin syndrome
  • Effect on driving and concentration
  • Not safe with monoamine oxidase inhibitors (MAOIs)
  • Doesn't help relieve withdrawal symptoms from other anxiety medications

Prices with our coupons for Vistaril vs. Buspar

Price Card Drug Icon
Hydroxyzine Pamoate30 capsules / 25mg
$9.55$14.18
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Buspirone60 tablets / 10mg
$4.00$4.00
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