Key takeaways
Hydroxyzine (Vistaril) and diphenhydramine (Benadryl) are both antihistamines, but they have different uses and availability. Hydroxyzine pamoate is a prescription-only medication used to relieve itching from allergies and sometimes for anxiety, though it's not a first-choice for anxiety due to its drowsiness side effect. Diphenhydramine, on the other hand, is available over-the-counter and is commonly used to treat allergy and cold symptoms, as well as for occasional sleep problems in people 12 years and older. While both medications can cause drowsiness, hydroxyzine pamoate is also available in liquid form and can be used in children as young as 6 years old for itching and anxiety. Diphenhydramine is not recommended for long-term use due to potential memory and confusion issues, especially in older adults. Additionally, hydroxyzine pamoate is not safe during pregnancy, whereas diphenhydramine is considered safe but should still be discussed with a healthcare provider.
