Key takeaways
Didanosine (Videx) and Trizivir (abacavir/lamivudine/zidovudine) are both medications used to treat HIV. They belong to the same subclass of medications called nucleoside reverse transcriptase inhibitors (NRTIs), which help stop the HIV virus from multiplying. However, there are several differences between them. Didanosine (Videx) was a single medication that has been discontinued in the U.S. due to serious side effects and lack of demand, while Trizivir is a combination of three medications and is still available, including in generic form. Trizivir is taken as one tablet twice daily and can be taken with or without food, whereas didanosine was also taken orally but is no longer available. Trizivir can cause serious side effects like allergic reactions, blood and muscle problems, and requires a genetic test before use. Didanosine also had serious side effects and could not be taken with certain other HIV medications. Trizivir is not a full HIV regimen on its own and should be taken with at least one other HIV medication, while didanosine was used as part of a combination therapy.
