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Simbrinza vs. Trusopt

Simbrinza is a combination eye drop containing two medications: brinzolamide (a carbonic anhydrase inhibitor) and brimonidine (an alpha-2 agonist). It's used to treat glaucoma and high pressure in the eye. The dosage for the eye drops is placed 1 drop placed directly into the eye(s) three times per day to lower the pressure in the eye. Simbrinza is not yet available as a lower-cost generic. Side effects include eye irritation, blurry vision, and changes in taste.

Treatment of high pressure in the eye in people ages 2 years and older with:

• Ocular hypertension
• Open-angle glaucoma

Reported in up to 5% of people:

• Blurry vision
• Eye irritation
• Changes in taste (e.g., bad taste in mouth)
• Dry mouth
• Eye allergy

• Only use in the eye
• Severe allergic reactions
• Risk for swelling of the cornea in certain people
• Risk for worsening of poor blood flow
• Risk for eye infection (from contamination)
• Take out soft contact lenses before using

Dorzolamide is an eye drop medication used to treat high pressure in the eye in people with glaucoma or ocular hypertension. The dosage is 1 drop applied directly into the affected eye(s) three times per day. It's available as a generic only as the brand-name medication Trusopt has been discontinued. Dorzolamide is a sulfa medication, so it might not be the best choice if you have a serious sulfa allergy. Side effects include burning or stinging in the eye and a bitter taste in the mouth.

Treatment of high pressure in the eye in people with:

• Ocular hypertension
• Open-angle glaucoma

• Burning or stinging in the eye (33%)
• Bitter taste (25%)
• Bacterial eye infection (10-15%)
• Allergic reaction in the eye (10%)

• Severe allergic reactions
• Risk for eye infection (from contamination)
• Risk for swelling of the cornea