Simbrinza is a combination eye drop containing two medications: brinzolamide (a carbonic anhydrase inhibitor) and brimonidine (an alpha-2 agonist). It's used to treat glaucoma and high pressure in the eye. The dosage for the eye drops is placed 1 drop placed directly into the eye(s) three times per day to lower the pressure in the eye. Simbrinza is not yet available as a lower-cost generic. Side effects include eye irritation, blurry vision, and changes in taste.
Treatment of high pressure in the eye in people ages 2 years and older with:
Simbrinza is a combination eye drop containing two medications that work differently to lower eye pressure.
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Reported in up to 5% of people:
Contact your healthcare provider immediately if you experience any of the following.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Burning, dry, or itching eyes
discharge or excessive tearing
hives or welts
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
skin rash
Incidence not known
Chest pain or discomfort
constricted, pinpoint, or small pupils (black part of the eye)
fast, pounding, or irregular heartbeat or pulse
hoarseness
irritation
joint pain, stiffness, or swelling
lightheadedness, dizziness, or fainting
redness of the skin
shortness of breath
slow or irregular heartbeat
swelling of the eyelids, face, lips, hands, or feet
tearing
throbbing pain
tightness in the chest
troubled breathing or swallowing
unusual tiredness
Get emergency help immediately if any of the following symptoms of overdose occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Burning and stinging sensation
change in color vision
change in taste
difficulty seeing at night
drowsiness
feeling of having something in the eye
headache
increase in blood flow to the whites of the eyes
increased sensitivity of the eyes to sunlight
lack or loss of strength
loss of taste
paleness of the eye or inner lining of the eyelid
redness and tiny bumps on the lining of the eyelid
Rare
Acid or sour stomach
belching
body aches or pain
congestion
crusting in the corner of the eye
double vision
dryness or soreness of the throat
excessive muscle tone
hair loss or thinning of the hair
hoarseness
indigestion
muscle stiffness
muscle tension or tightness
stomach discomfort, upset, or pain
tender, swollen glands in the neck
tightness in the chest
voice changes
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
How to use Simbrinza (brinzolamide / brimonidine):
It's possible for Simbrinza (brinzolamide / brimonidine) to cause headaches as a side effect. People have reported headaches while they used brimonidine, one of the ingredients in Simbrinza. Consider making some lifestyle changes to help manage headaches, such as drinking plenty of water during the day and breathing exercises to minimize stress. Speak with your prescriber if you get headaches after you use Simbrinza (brinzolamide / brimonidine) and they're too bothersome for you to handle.
No, Simbrinza (brinzolamide / brimonidine) doesn't contain a beta blocker. Simbrinza contains two active ingredients, brinzolamide (a carbonic anhydrase inhibitor) and brimonidine (an alpha-2 agonist). These three types of eye drops work differently to lower eye pressure. Depending on how severe your eye condition is, it's possible that your eye specialist might prescribe multiple eye drop medications for you to use. For example, they might prescribe a beta blocker eye drop medication, such as timolol (Timoptic) or betaxolol (Betoptic S), to take with Simbrinza (brinzolamide / brimonidine).
You can put Simbrinza (brinzolamide / brimonidine) in the refrigerator or in a safe place at room temperature. The recommended temperature range for storage is 36 to 77 degrees Fahrenheit.
No, Simbrinza isn't available as a lower-cost generic. But the two active ingredients in Simbrinza, brinzolamide and brimonidine, each come as separate eye drop medications that are both available as lower-cost generics. If you end up switching to using brinzolamide and brimonidine as separate eye drop medications, just make sure that you place the drop of each medications into eye about 5 minutes apart. This helps each medication get fully absorbed into your eye.
Some examples of reasonable alternatives to Simbrinza (brinzolamide / brimonidine) that you can consider include Combigan (brimonidine / timolol) and Cosopt (dorzolamide / timolol). In general, glaucoma eye drops differ by how they work in the eye, how many times a day they're used, and whether they're available as lower-cost generics. Additionally, glaucoma eye drops can come as single-ingredient medications or as a combination of two medications. Speak with your eye specialist to learn more about what other treatment options are appropriate and available for you.
Simbrinza and Cosopt are combination eye drop medications for glaucoma and high eye pressure. But they contain different active ingredients and have different instructions. Simbrinza contains brinzolamide and brimonidine. You have to shake the Simbrinza bottle well before using, and you use the eye drops three times per day. On the other hand, Cosopt contains dorzolamide and timolol. You don't need to shake the Cosopt bottle, and you use the eye drops twice per day. Studies showed that the active ingredients in each eye drop medication work well and are first-choice treatment options. Talk to your eye specialist to learn more about comparing between Simbrinza and Cosopt.
Simbrinza and Combigan are both combination eye drop medications containing two active ingredients that work differently to help lower eye pressure. Simbrinza contains brimonidine and brinzolamide, whereas Combigan contains brimonidine and timolol. You'll need to shake the Simbrinza bottle before each time you use the eye drops, and it's used three times per day. But Combigan doesn't require any shaking before use and the eye drop is used twice per day. Both brand names are good choices for treating high eye pressure. Ask your eye specialist about comparing between Simbrinza and Combigan.
No, Simbrinza (brinzolamide / brimonidine) isn't discontinued. It's still available for use. Ask your local pharmacy whether they have it in stock. They can order it for you if they don't have the medication available at the moment.
Simbrinza (brinzolamide / brimonidine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Only put Simbrinza (brinzolamide / brimonidine) eye drops on the surface of the eye. Don't swallow the medication or use the suspension as an injection.
Although Simbrinza (brinzolamide / brimonidine) is mainly absorbed into the eye, it's possible for a little bit of the medication to get absorbed into your body through the eye. Tell your care team if you're allergic to sulfa medications like Bactrim (sulfamethoxazole / trimethoprim). Since Simbrinza contains brinzolamide and brinzolamide is a type of sulfa medication, you might also be allergic to Simbrinza and have a serious reaction when you use Simbrinza.
Seek medical help right away if you have any signs of an allergic reaction, such as trouble breathing, skin rash or redness, itching, or swelling. Contact your prescriber if you have any symptoms in or around your eyes, such as eye irritation, pain, or itching.
Simbrinza contains brinzolamide, which can raise the risk of swelling of the cornea (or corneal edema) in certain people. The cornea is the outermost layer of the eye that protects the front of the eye. Talk to your eye specialist before you start Simbrinza (brinzolamide / brimonidine) if you've ever been told that your cornea is thin or or that you have a low number of cells on the cornea.
Simbrinza contains brimonidine. Based on how brimonidine works, there's a very small risk that the medication can worsen medical conditions related to poor blood flow. This might be a problem for people who already have poor blood flow to the brain, heart, hands, feet, or other important parts of the body. Let your prescriber know about your full medical history before you start Simbrinza (brinzolamide / brimonidine) so your care team can follow up with you about your health.
Wash your hands before each time you use Simbrinza (brinzolamide / brimonidine). Also be careful not to let the tip of the eye drop bottle from touching your eye or any other surface. Don't touch the dropper tip with your hands. It's important to follow these steps to prevent contaminating the medication with germs. Otherwise, you could get eye infections, like bacterial keratitis (a bacterial infection of the cornea).
Simbrinza (brinzolamide / brimonidine) has a preservative in it. This preservative, benzalkonium chloride, can get absorbed onto soft contact lenses and cause damage. Remove the soft contact lens from your eye before you place a drop of Simbrinza (brinzolamide / brimonidine) in the eye. Wait at least 15 minutes after you place the eye drop in before you put your contacts back in.
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 8ml of 1%/0.2% | 1 eye dropper | $215.73 | $215.73 |
Simbrinza contains 1% of brinzolamide and 0.2% of brimonidine.
The typical dose is 1 drop in the affected eye(s) 3 times daily.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Simbrinza (brinzolamide / brimonidine) will not be safe for you to take.
Treatment of high pressure in the eye in people ages 2 years and older with:
Treatment of high pressure in the eye in people ages 2 years and older with: