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Simbrinza vs. Cosopt

Simbrinza is a combination eye drop containing two medications: brinzolamide (a carbonic anhydrase inhibitor) and brimonidine (an alpha-2 agonist). It's used to treat glaucoma and high pressure in the eye. The dosage for the eye drops is placed 1 drop placed directly into the eye(s) three times per day to lower the pressure in the eye. Simbrinza is not yet available as a lower-cost generic. Side effects include eye irritation, blurry vision, and changes in taste.

Treatment of high pressure in the eye in people ages 2 years and older with:

• Ocular hypertension
• Open-angle glaucoma

Reported in up to 5% of people:

• Blurry vision
• Eye irritation
• Changes in taste (e.g., bad taste in mouth)
• Dry mouth
• Eye allergy

• Only use in the eye
• Severe allergic reactions
• Risk for swelling of the cornea in certain people
• Risk for worsening of poor blood flow
• Risk for eye infection (from contamination)
• Take out soft contact lenses before using

Cosopt is a combination ophthalmic drop (eye drop) medication that contains dorzolamide (a carbonic anhydrase inhibitor) and timolol (a beta blocker). It's used to lower eye pressure for certain people with glaucoma or high eye pressure. Typically, one drop of Cosopt (dorzolamide / timolol) is placed into the affected eye(s) twice a day. Common side effects of this medication include changes in taste, blurry vision, and itchy eyes. Cosopt (dorzolamide / timolol) is available as both brand name and generic medications. It comes in a multi-dose bottle, as well as single-use, preservative-free vials.

• To lower eye pressure in people with open-angle glaucoma or high eye pressure

• Changes in taste (up to 30%)
• Eye burning or stinging (up to 30%)
• Blurry vision (5-15%)
• Itchy eye (5-15%)
• Corneal inflammation (5-15%)
• Eye redness (5-15%)

• Risk of difficulty breathing
• Heart failure
• Severe allergic and skin reactions
• Hiding symptoms of low blood sugar
• Hiding symptoms of overactive thyroid
• Greater risk during surgery
• Cornea swelling
• Eye inflammation and infection
• Risk of muscle weakness